DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5687 and Slc5a8

DIOPT Version :9

Sequence 1:	NP_001286910.1	Gene:	CG5687 / 38255	FlyBaseID:	FBgn0035293	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_663398.2	Gene:	Slc5a8 / 216225	MGIID:	2384916	Length:	611	Species:	Mus musculus

Alignment Length:	594	Identity:	208/594 - (35%)
Similarity:	330/594 - (55%)	Gaps:	58/594 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 TFSGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGS-EMSIFPVTLSLTTSFITAIELLG 158
            :|..:|||:..|||:||..|||:|.|...|..:|.:||:|. .||..||.||||.||::|:.:||
Mouse     9 SFVVWDYVVFAGMLLISAAIGIYYAFAGGGQQTSKDFLMGGRSMSAVPVALSLTASFMSAVTVLG 73

  Fly   159 NPSEMYFQGTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRFGKEIRILGAVLYVIQ 223
            .|:|:|..|..|.:.||....|:.::.::|.|:::::.:||.||||.:||.:.||:.|.:|:::|
Mouse    74 TPAEVYRFGAIFSIFVITYFFVVVISAEVFLPVFYRLGITSTYEYLELRFNRCIRLCGTILFIVQ 138

  Fly   224 MCFYTAVAVLAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVVIADSFQAAVLAVSLVLI 288
            ...||.:.:.|||:||::.||.|...|||...|||.||.:.||:||||..|.||..::......:
Mouse   139 TILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFASV 203

  Fly   289 VGLGCFYSGNPIQVFQTASDHNRLEFFNMDPDPTTRHTVWSVVIGGFFYWTSLFCTNQASVQKCM 353
            :...........::...|.:..||.|:|.||:|..|||.|::||||.|.||:::..||:.||:.:
Mouse   204 IIQASITQHGINKILSDAFNGGRLNFWNFDPNPLQRHTFWTIVIGGTFTWTTIYGVNQSQVQRYI 268

  Fly   354 SLKSLRLAKIALGFAIIGLIVVFLLNFYTGLMVFTHYADCDPLTAGRISATDQLLPYYVINTYEH 418
            |.||...||::|...::||.|:...:.:.||.:::.|.:|||.|:.::||.|||:||.|::..::
Mouse   269 SCKSRLHAKLSLYVNLVGLWVILTCSIFCGLALYSRYRECDPWTSKKVSAIDQLMPYLVLDILKN 333

  Fly   419 ISSVAGIFVAGIFAASLGTVASALNSLSAVTCEDLLVNGMNIKISPEKGATY-AKWMSLGFGIAS 482
            ...|.|:|||..::.:|.||:|::|:|:|||.|||:  ....|...||..:: ::.||:.:|...
Mouse   334 YPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLI--KPRFKSLSEKSLSWISQGMSVLYGALC 396

  Fly   483 FGLVFIVEHLGGVLQATLTLNGLIGGVTLGLFVLGIACKQANTKGAFYGGLLSLALVIFVGVVAQ 547
            .|:..:...:|.:|||.|::.|::||..||||.|||....||:.||..|.|...|:.::||:.||
Mouse   397 IGMAALASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSIGALTGLLAGFAISLWVGIGAQ 461

  Fly   548 IV-SVEQPALPTSIDKCDCHVNMTNIIGSLLTE----------------PLEVIEEGGFTSWPIF 595
            :. .:.:..||..::...|::..........||                ||       ..:|  :
Mouse   462 LYPPLPERTLPLPLETYGCNITHNGSDWMSTTEMPFSTSAFQIHNAERTPL-------MDNW--Y 517

  Fly   596 RLSYMWYSMIGCLLTVFLGWFISLII----------------DFIQRRNVLK------------I 632
            .|||:::|.||.|.|:|:|..|||..                ||:...:|.|            :
Mouse   518 SLSYLYFSTIGTLTTLFVGILISLSTGGRKQNLDPRFLLTKQDFLSNFDVFKKRNHVLNYKLHPV 582

  Fly   633 TGKDIDNPA 641
            .....||||
Mouse   583 EVGGTDNPA 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5687	NP_001286910.1	SLC5sbd_NIS-SMVT	99..620	CDD:271383	198/539 (37%)
Slc5a8	NP_663398.2	SLC5sbd_SMCT1	7..549	CDD:271402	200/550 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920