DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5687 and Slc5a6

DIOPT Version :9

Sequence 1:	NP_001286910.1	Gene:	CG5687 / 38255	FlyBaseID:	FBgn0035293	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_570102.1	Gene:	Slc5a6 / 170551	RGDID:	69648	Length:	634	Species:	Rattus norvegicus

Alignment Length:	564	Identity:	180/564 - (31%)
Similarity:	308/564 - (54%)	Gaps:	37/564 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 SAPSHK--------ATFSGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGS-EMSIFPVT 143
            :|||:.        :|||..|||:...:||:||.||:::.....|..:..|.|:.. :|...||.
  Rat     7 AAPSYTTSDTNRVISTFSVVDYVVFGLLLVLSLVIGLYHACRGWGRHTVGELLMADRKMGCLPVA 71

  Fly   144 LSLTTSFITAIELLGNPSEMYFQGTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRF 208
            |||..:|.:|:.:||.|:|:|..|||:..:.....:.:.:...||.|:::::.|||.||||.:||
  Rat    72 LSLLATFQSAVAILGGPAEIYRFGTQYWFLGCSYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRF 136

  Fly   209 GKEIRILGAVLYVIQMCFYTAVAVLAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVVIA 273
            .|.:||.|.|.::.||..|..||:.||::||:..||.|..::|:.:.:||..|::.||:|||:..
  Rat   137 NKAVRICGTVTFIFQMVVYMGVALYAPSLALNAVTGFDLWLSVLALGIVCNIYTALGGLKAVIWT 201

  Fly   274 DSFQAAVLAVSLVLIVGLGCFYSGNPIQVFQTASDHNRLEFFNMDPDPTTRHTVWSVVIGGFFYW 338
            |.||..::.:..::::.:|....|....|:..||.|..:....:||||..|||.|::..||.|..
  Rat   202 DVFQTLIMFLGQLVVIIVGAAKVGGLGHVWAVASQHGLISGIELDPDPFVRHTFWTLAFGGVFMM 266

  Fly   339 TSLFCTNQASVQKCMSLKSLRLAKIALGFAIIGLIVVFL-LNFYTGLMVFTHYADCDPLTAGRIS 402
            .||:..|||.||:.:|..|.:.|.::. :|:.....|.| ::...||::|.:|...........:
  Rat   267 LSLYGVNQAQVQRYLSSHSEKAAVLSC-YAVFPCQQVALCMSCLIGLVMFAYYKKYSMSPQQEQA 330

  Fly   403 ATDQLLPYYVINTYEHISSVAGIFVAGIFAASLGTVASALNSLSAVTCEDLLVNGMNIKISPEKG 467
            |.|||:.|:|::..:.:..:.|:|||.:|:.||.|::||.|||:.||.|| |:.....:::..:.
  Rat   331 APDQLVLYFVMDLLKDMPGLPGLFVACLFSGSLSTISSAFNSLATVTMED-LIQPWFPQLTETRA 394

  Fly   468 ATYAKWMSLGFGIASFGLVFIVEHLGGVLQATLTLNGLIGGVTLGLFVLGIACKQANTKGAFYGG 532
            ...::.::..:|:...|:.::..|||.||||.|::.|::||..||||.||:....||..||..|.
  Rat   395 IMLSRSLAFAYGLVCLGMAYVSSHLGSVLQAALSIFGMVGGPLLGLFCLGMFFPCANPLGAIVGL 459

  Fly   533 LLSLALVIFVGVVAQIVSVEQPA------------LPTSIDKCDCHVNMTNIIGSLLTEPLEVIE 585
            |..|.:..::| :..|||....|            ||:::..    ..:|.::.|.|::|..:.:
  Rat   460 LTGLTMAFWIG-IGSIVSRMSSAAASPPLNGSSSFLPSNLTV----ATVTTLMPSTLSKPTGLQQ 519

  Fly   586 EGGFTSWPIFRLSYMWYSMIGCLLTVFLGWFISLIIDFIQRRNV 629
                    .:.|||:|||.......:.:|..:||:...::.|::
  Rat   520 --------FYSLSYLWYSAHNSTTVIAVGLIVSLLTGGMRGRSL 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5687	NP_001286910.1	SLC5sbd_NIS-SMVT	99..620	CDD:271383	172/534 (32%)
Slc5a6	NP_570102.1	SLC5-6-like_sbd	23..548	CDD:382020	175/539 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920