Protein Alignment CG5687 and SLC5A11

DIOPT Version :10

• Sequence 1: NP_647678.3
• Gene: CG5687 / 38255
• FlyBaseID: FBgn0035293
• Length: 683
• Species: Drosophila melanogaster
• Sequence 2: NP_001339171.1
• Gene: SLC5A11 / 115584
• HGNCID: 23091
• Length: 675
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 141/590 - (23%)
• Similarity: 248/590 - (42%)
• Gaps: 107/590 - (18%)

  Fly    79 PASAELEECSAPSHKATFSGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGSEMSIFPVT 143
            |...:|:...|...|....| |..:|:...:..|.:|::.....|..:....||.|.:|..:||.
Human     8 PQPPQLDPLDAFPQKGLEPG-DIAVLVLYFLFVLAVGLWSTVKTKRDTVKGYFLAGGDMVWWPVG 71

  Fly   144 LSLTTSFITAIELLGNPSEMYFQGTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRF 208
            .||..|.:.:...:|........|.......:..:..:.:...||.|||...::|:..|||..||
Human    72 ASLFASNVGSGHFIGLAGSGAATGISVSAYELNGLFSVLMLAWIFLPIYIAGQVTTMPEYLRKRF 136

  Fly   209 GK-EIRILGAVLYVIQMCFYTAVAV--LAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAV 270
            |. .|.|:.||||:. :..:|.::|  .|.||.:.::..||..:|:|.:..:...|:..||:.||
Human   137 GGIRIPIILAVLYLF-IYIFTKISVDMYAGAIFIQQSLHLDLYLAIVGLLAITAVYTVAGGLAAV 200

  Fly   271 VIADSFQAAVLAVSLVLIVGLGCFYSGNPI-------QVFQTASDHNRLE----------FFNMD 318
            :..|:.|..::.:..:.::|    ||...:       :.:..|...||.|          .|::.
Human   201 IYTDALQTLIMLIGALTLMG----YSFAAVGGMEGLKEKYFLALASNRSENSSCGLPREDAFHIF 261

  Fly   319 PDPTTRHTVWSVVIGG-----FFYWTSLFCTNQASVQKCMSLKSLRLAK-IALGFAIIGLIVVFL 377
            .||.|....|..|:.|     .:||    ||:|..||:.::.|:|..|| .||..|.:.::.:|:
Human   262 RDPLTSDLPWPGVLFGMSIPSLWYW----CTDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFI 322

  Fly   378 LNF--YTGLMVFTHYADC-DPLTAGRI-----SATDQLLPYYVINTYEHISSVAGIFVAGIFAAS 434
            :.|  ....::|.....| ||....:|     ..:|...|..|:....  :.:.|:.:|.:.||.
Human   323 MVFPGMVSRILFPDQVACADPEICQKICSNPSGCSDIAYPKLVLELLP--TGLRGLMMAVMVAAL 385

  Fly   435 LGTVASALNSLSAVTCEDLLVNGMNIKISPEKGATYAKWMSLGFGIASF-----------GLVFI 488
            :.::.|..||.|.:...||. |.:..:.|.::.....:...|...:.|.           |.:||
Human   386 MSSLTSIFNSASTIFTMDLW-NHLRPRASEKELMIVGRVFVLLLVLVSILWIPVVQASQGGQLFI 449

  Fly   489 -VEHLGGVLQATLTLNGLIGGVTLGLFVLGIACKQANTKGAFYGGLLSLALVIFVGVVAQIVSVE 552
             ::.:...||..:.:          :|::|...|:.|.||||: ||:|..|:..|.:|...:.|
Human   450 YIQSISSYLQPPVAV----------VFIMGCFWKRTNEKGAFW-GLISGLLLGLVRLVLDFIYV- 502

  Fly   553 QPALPTSIDKCDCHVNMTNIIGSLLTEPLEVIEEGGFTSWPIF--RLSYMWYSMIGCLLTVF--- 612
            ||       :||              :|.|         .|:.  .:.|:::|||...:|:.
Human   503 QP-------RCD--------------QPDE---------RPVLVKSIHYLYFSMILSTVTLITVS 537

  Fly   613 -LGWF 616
             :.||
Human   538 TVSWF 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5687	NP_647678.3	SLC5sbd_NIS-SMVT	99..620	CDD:271383	136/570 (24%)
SLC5A11	NP_001339171.1	SLC5sbd_SGLT6	28..675	CDD:271381	136/569 (24%)