DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5687 and Slc5a10

DIOPT Version :9

Sequence 1:	NP_001286910.1	Gene:	CG5687 / 38255	FlyBaseID:	FBgn0035293	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	XP_006532041.1	Gene:	Slc5a10 / 109342	MGIID:	1926089	Length:	611	Species:	Mus musculus

Alignment Length:	586	Identity:	123/586 - (20%)
Similarity:	229/586 - (39%)	Gaps:	130/586 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 DYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGSEMSIFPVTLSLTTS-----FITAIELLGN 159
            |.:::.....:::.:||:........:.|..||.|.:|:.:|:..||..|     ....:...|.
Mouse    55 DIIVISVYFALNVAVGIWSACRANKNTVSGYFLAGRDMAWWPIGASLFASSEGSGLFVGLAGSGA 119

  Fly   160 PSEMYFQGTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRF-GKEIRILGAVLYVIQ 223
            ...:...|.::.::.:|                         ||:..|| |:.||...:|| .:.
Mouse   120 AGGLAVAGFEWNIVTLP-------------------------EYIQKRFGGQRIRTYLSVL-SLM 158

  Fly   224 MCFYTAVAV--LAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVVIADSFQAAVLAVSLV 286
            :..:|.:::  .|.|:.:....|.:..::.:|...:...|:..||:..|:..|:.|..::.|..|
Mouse   159 LSVFTKISIDLYAGALFVHICLGWNFYLSTILTLAITALYTIAGGLATVIYTDALQTIIMVVGAV 223

  Fly   287 LI-------VG----LGCFYS-GNPIQVFQTASDH-NRLEFFNMDPDPTTRHTVWS-----VVIG 333
            ::       :|    |...|: ..|.:.....:.| .|.:..:|..||:|....|:     :.|.
Mouse   224 ILAVKAFNQIGGYEQLEAAYAQAIPSRTIPNTTCHLPRADAMHMFRDPSTGDLPWTGMTFGLTIM 288

  Fly   334 GFFYWTSLFCTNQASVQKCMSLKSLRLAK-----------IALGFAII-GLIVVFLLNFYTGLMV 386
            ..:||    ||:|..||:.:|.::|..||           :.:|..|: |:|...|.....|.:|
Mouse   289 ATWYW----CTDQVIVQRSLSARNLNHAKAGSILASYLKMLPMGLMIMPGMISRVLFPDDVGCVV 349

  Fly   387 FTHYADCDPLTAGRISATDQLLPYYVINTYEHISSVAGIFVAGIFAASLGTVASALNSLSAVTCE 451
               .::|.......|..::...|..|:....  ..:.|:.:|.:.||.|.::.|..||.|.:...
Mouse   350 ---PSECLRACGAEIGCSNIAYPKLVMELMP--IGLRGLMIAVMMAALLSSLTSIFNSSSTLFTM 409

  Fly   452 D--------------LLVNGMNIKISPEKGATYAKWMSLGFGIASFGLVFIVEHLGGVLQATLTL 502
            |              |||..:.|.:.  .|.:.| |:.:..|..|..|...::.:...|...:|
Mouse   410 DIWRQLRPSAGERELLLVGRLVIVVL--IGVSVA-WIPVLQGSNSGQLFIYMQSVTSSLAPPVT- 470

  Fly   503 NGLIGGVTLGLFVLGIACKQANTKGAFYGGLLSLALVIFVGVVAQIVSVEQPALPTSIDKCDCHV 567
                     .:|:|||..::||.:|||:|.:..|.    ||.:..::....|..|       |
Mouse   471 ---------AIFILGIFWRRANEQGAFWGLMAGLV----VGALRLVLEFLYPEPP-------C-- 513

  Fly   568 NMTNIIGSLLTEPLEVIEEGGFTSWPIFRLSYMWYSMIGCLLTVFLGWFISLIIDFIQRRNVLKI 632
                  |.:.|.|.           |:..|.|:.:::...|||..:....||:....|:|.:..:
Mouse   514 ------GQIDTRPA-----------PLRSLHYLHFAIALFLLTCAVMAAGSLLSPPPQQRQIENL 561

  Fly   633 T 633
            |
Mouse   562 T 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5687	NP_001286910.1	SLC5sbd_NIS-SMVT	99..620	CDD:271383	119/571 (21%)
Slc5a10	XP_006532041.1	SLC5-6-like_sbd	52..611	CDD:382020	123/586 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810