DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5687 and slc5a10

DIOPT Version :9

Sequence 1:	NP_001286910.1	Gene:	CG5687 / 38255	FlyBaseID:	FBgn0035293	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	XP_017211446.2	Gene:	slc5a10 / 100007379	ZFINID:	ZDB-GENE-110922-5	Length:	637	Species:	Danio rerio

Alignment Length:	573	Identity:	126/573 - (21%)
Similarity:	233/573 - (40%)	Gaps:	100/573 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 TFSGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGSEMSIFPVTLSLTTS------FI-- 151
            :||..|.:::....::::.:||:........:.|..||.|.:|:.:|:..||..|      ||
Zfish    15 SFSVSDIIVIGAYFLLNVAVGIWSSCRVSRNTLSGYFLAGRDMAWWPIGASLFASSEGSGLFIGL 79

  Fly   152 TAIELLGNPSEMYFQ-GTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRFGKE-IRI 214
            ......|..:...|: ...:.|:.:..|         |.|:|....:.:..||||.|||.| ||:
Zfish    80 AGTGAAGGIAVAGFEWNATYALLALAWV---------FVPVYVSSGIVTMPEYLGRRFGGERIRM 135

  Fly   215 -LGAVLYVIQMCFYTAVAVLAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVVIADSFQA 278
             |.|:..::.:....:..:.:.|:.:....|.:..::.||:.||...|:..||:.||:..|:.|.
Zfish   136 YLSALSLLLSVFTKISTDLYSGALFVQVCLGWNLYLSTVLMLVVTALYTIAGGLAAVIYTDTLQT 200

  Fly   279 AVLAVSLVLI-------VG-----LGCFYSGNPIQVFQTASDH-NRLEFFNMDPDPTTRHTVW-- 328
            .::.:..|::       :|     ...:....|.::....:.| .|.:..::..||......|
Zfish   201 FIMIIGAVILTITAFNKIGGYSNLESVYLQAVPSKIIPNTTCHLPRHDAMHLFRDPVHGDLPWPG 265

  Fly   329 ---SVVIGGFFYWTSLFCTNQASVQKCMSLKSLRLAKIALGFAIIGLIVVFLLNFYTGLMVFTHY 390
               .:.|...:||    ||:|..||:.:|.|||..||.|..||....::..:.....|::....|
Zfish   266 MTLGLTIIATWYW----CTDQVIVQRSLSAKSLSHAKGASIFASYLKLLPMMFIILPGMISRALY 326

  Fly   391 AD---------CDPLTAGRISATDQLLPYYVINTYEHISSVAGIFVAGIFAASLGTVASALNSLS 446
            .|         |..:....:..::...|..||....  |.:.|:.:|.:.||.:.::.|..||.|
Zfish   327 PDTVACVDPEECVKVCGAEVGCSNIAFPKLVIELMP--SGLRGLMIAVMMAALMSSLTSIFNSSS 389

  Fly   447 AVTCEDLLVNGMNIKISPEKGATYAKWMSLGFGIASFGLVFIVEHLGGVLQATLT--LNGLIGGV 509
            .:..       |:|.....:||:..:.:.:| .|.:..||.|......:||:..:  |...|..|
Zfish   390 TLFT-------MDIWKKYRRGASEKELLLVG-RIVTVILVVISVVWIPILQSANSGQLYVYIQSV 446

  Fly   510 T-------LGLFVLGIACKQANTKGAFYGGLLSLALVIFVGVVAQIVSVEQPALPTSIDKCDCHV 567
            |       ..:||:.:..|:.|..|||:|.::.|.    ||:...::....|.     .:|....
Zfish   447 TSYLAPPVTAIFVMAVFWKRTNEAGAFWGLMVGLV----VGLTRMVLEFAFPP-----PRCGVFD 502

  Fly   568 NMTNIIGSLLTEPLEVIEEGGFTSWPIFRLSYMWYSMIGCLLTVFLGWFISLI 620
            ...:::.|                     :.|:.:::|.|.||..:...|||:
Zfish   503 PAPSVLRS---------------------MHYLHFAIILCALTAIVVAVISLL 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5687	NP_001286910.1	SLC5sbd_NIS-SMVT	99..620	CDD:271383	123/567 (22%)
slc5a10	XP_017211446.2	SLC5sbd_SGLT5	17..637	CDD:212058	125/571 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810