DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5687 and slc5a3a

DIOPT Version :9

Sequence 1:	NP_001286910.1	Gene:	CG5687 / 38255	FlyBaseID:	FBgn0035293	Length:	683	Species:	Drosophila melanogaster
Sequence 2:	NP_001153309.1	Gene:	slc5a3a / 100004287	ZFINID:	ZDB-GENE-090312-3	Length:	671	Species:	Danio rerio

Alignment Length:	560	Identity:	125/560 - (22%)
Similarity:	231/560 - (41%)	Gaps:	76/560 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 ATFSGYDYVILLGMLVISLGIGIFYGFFQKGGSSSNEFLLGSEMSIFPVTLSLTTSFITAIELLG 158
            :|....|.:::....|:.|..|.|..:....|:.|..||.|..|:.|.:..||..|.|.:...:|
Zfish     3 STMEAADIIVVAMYFVLVLCFGFFSMWRANRGTVSGYFLAGRSMNWFVIGASLFVSNIGSEHFIG 67

  Fly   159 NPSEMYFQGTQFVLIVIPMVIVIPVAVKIFYPIYFKMELTSCYEYLGIRF-GKEIRILGAVLYVI 222
            ........|..........::::.:...:|.|:|....:.:..|||..|| |..::|..|.|.::
Zfish    68 LAGSGAASGLAVGAWEFNAILLLQLLGWVFIPVYIHSGVYTMPEYLSKRFGGNRLKIYFASLTLL 132

  Fly   223 QMCF-YTAVAVLAPAIALSKATGLDTKIAVVLIYVVCVFYSSQGGMKAVVIADSFQA-------- 278
            ...| ..:|.:.:.|:.:.::.|.:..::::|:..:....:..||:.||:..|:.||
Zfish   133 LYIFTKLSVDLYSGALFIQESLGWNLYLSIILLITLTALLTVTGGLVAVIYTDTLQAFLMISGAL 197

  Fly   279 AVLAVSLVLIVGL-GC---FYSGNPIQVFQTASDHNRLEFFN---MDP---------DPTTRHTV 327
            .::|:|||.:.|| |.   :.:..|...|.|.  .|.|.:.|   ::|         .|..:...
Zfish   198 CLMAISLVKVGGLEGLRTKYMNALPNITFITL--ENNLTYSNSCHVNPKADSFKLLRSPLDKDLP 260

  Fly   328 WSVVIGG-----FFYWTSLFCTNQASVQKCMSLKSLRLAK-IALGFAIIGLIVVFLLNFYTGLMV 386
            |...:.|     .:||    |.:|..||:.::.:::..|| ..|...::.::.:|:: ...|::.
Zfish   261 WPAFLLGQTPASIWYW----CADQVIVQRVLAARNIAHAKGSTLLAGVLKVLPMFII-VIPGMIS 320

  Fly   387 FTHYAD---------CDPLTAGRISATDQLLPYYVINTYEHISSVAGIFVAGIFAASLGTVASAL 442
            ...:||         |..:...|...|:...|..|:|...  ..:.|:.:|.:.||.:..:.|..
Zfish   321 RVLFADELACIGPEHCMQVCNSRAGCTNTAYPRLVMNIMP--VGLRGLMMAVMLAALMSDLDSIF 383

  Fly   443 NSLSAVTCEDLLVNGMNIKISPEKGATYAKWMSLGFGIASFGLVFIVEHLGGVLQATLTLNGLIG 507
            ||.|.:...|:.....:...|.|.......::.|...|:...:.|::|..||  |..|.:..:..
Zfish   384 NSASTIFTLDIYKMIRHQASSKELMVVGRLFVVLIVAISIAWVPFVIEMQGG--QMFLYIQEVSD 446

  Fly   508 GVT---LGLFVLGIACKQANTKGAFYGGLLSLALVIFVGVVAQIVS--VEQPALPTSIDK----C 563
            .:|   ..||:||:..|:.|..|||:||.:.|.|    |:|..|::  ..:|...:..|:    .
Zfish   447 YLTPPIAALFLLGVLWKRCNETGAFWGGFVGLIL----GIVRLILAFVYREPDCDSVDDRPAFIK 507

  Fly   564 DCHV-----------NMTNIIGSLLTEPLEVIEEGGFTSW 592
            |.|.           ....::.||.|.|....:....|.|
Zfish   508 DVHFMYVAAVLFWVSGFVMVVVSLCTNPPSKEQISKTTLW 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5687	NP_001286910.1	SLC5sbd_NIS-SMVT	99..620	CDD:271383	124/555 (22%)
slc5a3a	NP_001153309.1	SLC5-6-like_sbd	9..671	CDD:294310	124/554 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810