Protein Alignment Dbx and nkx2.1

DIOPT Version :10

• Sequence 1: NP_647677.2
• Gene: Dbx / 38254
• FlyBaseID: FBgn0261723
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_571851.1
• Gene: nkx2.1 / 81883
• ZFINID: ZDB-GENE-010404-1
• Length: 346
• Species: Danio rerio
• Alignment Length: 479
• Identity: 106/479 - (22%)
• Similarity: 151/479 - (31%)
• Gaps: 183/479 - (38%)

  Fly   175 MQPQHIWPYLQQNFMQQHSHQYQQHHQQQQ-------PHSHPQHQPLAVPGHQHSHPHSHHHHHH 232
            |.|:|..|:...:.:......|::...:..       .:..||....|:..|...|..:....:|
Zfish     3 MSPKHTTPFSVSDILSPLEESYKKVSMEGNNLGAPLASYRQPQVTQAAMQQHHMGHNGTVPAAYH 67

  Fly   233 HPGAGHAHFPHPAFLTHQLPPHQHHQQQQHVQQQHPGNSCQPQTASSSSSPGSTISDSDNNHGAS 297
            ...||.:...|.|.                      |..|.....:.|..|    :..|...|::
Zfish    68 MTAAGVSQLSHTAM----------------------GGYCNGNLGNMSDLP----AYQDGMRGST 106

  Fly   298 TANGNGSGTGNSGQDARPHELANSNPDEDSSASRRLTQDKQQQQQLLGAGGTGGGGGGGHGHGHP 362
            ||. :..||               |||...|...|..                 |...|...|
Zfish   107 TAT-SWYGT---------------NPDPRFSTISRFM-----------------GSSSGMNMG-- 136

  Fly   363 TPPPPPPPPVIAKPMPSRPTPFLPHTLNHPHLHSLLAHCRNPYMSVGAQVFPLPPGQGFPWAHST 427
                            |..|           |.||        ..||..:.||.         ||
Zfish   137 ----------------SMST-----------LSSL--------ADVGKGMGPLT---------ST 157

  Fly   428 RGKPRRGMMRRAVFSDSQRKGLEKRFQQQKYISKPDRKKLAERLGLKDSQVKIWFQNRRMKW-RN 491
               |||  .||.:||.:|...||:||:||||:|.|:|:.||..:.|..:||||||||.|.|. |.
Zfish   158 ---PRR--KRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQ 217

  Fly   492 SKER----ELLASGGSRDQTLPNKNNPNPDLSDAKCDRPLTPLSPSLLSPNGSATPPPPGAVAKD 552
            :|::    ::....||..|                          ...||...|.|    .:.||
Zfish   218 AKDKVSQQQMQQDNGSCQQ--------------------------QQQSPRRVAVP----VLVKD 252

  Fly   553 EPPT--AAVTP------------------KSPQSVSSRSSPSVGYGLQISSPPPLLTSLKMGDQS 597
            ..|.  ::.||                  .:..|:|...|..||...|         ||.:|..:
Zfish   253 GKPCQGSSHTPNTGVQNHHHQGGNVMFMTNTSLSMSQHQSQQVGSAGQ---------SLDLGQHA 308

  Fly   598 AS--ATPTPLPGTTVSSAAASPPG 619
            ||  :..|.:||.:..:::.|..|
Zfish   309 ASPPSLQTQVPGLSHLNSSGSEYG 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dbx	NP_647677.2	Homeodomain	437..491	CDD:459649	29/54 (54%)
nkx2.1	NP_571851.1	Homeodomain	160..216	CDD:459649	30/57 (53%)