Protein Alignment Dbx and NKX6-1

DIOPT Version :10

• Sequence 1: NP_647677.2
• Gene: Dbx / 38254
• FlyBaseID: FBgn0261723
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_006159.2
• Gene: NKX6-1 / 4825
• HGNCID: 7839
• Length: 367
• Species: Homo sapiens
• Alignment Length: 324
• Identity: 85/324 - (26%)
• Similarity: 115/324 - (35%)
• Gaps: 88/324 - (27%)

  Fly   267 HPGNSCQPQTASSSSSPGSTISDSDNNHGAS----TANGNGSGTGNSGQD---ARPH-------- 316
            :|.....|.::|||||..|:.|.....|...    .|.|..|..|:..|.   |.||
Human    40 YPPLPAGPPSSSSSSSSSSSPSPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPHGINDILSR 104

  Fly   317 ---------ELANSNPDEDSSASRRLTQDKQQQQQLLGAGGTGGGGGGGHG--HGHP-----TPP 365
                     .|.:::|...||:|...............|...........|  .|.|     :||
Human   105 PSMPVASGAALPSASPSGSSSSSSSSASASSASAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPP 169

  Fly   366 PPPP-----PPVIA--------KP---MPSRPTPFLPHTLNHPHLHSLLAHCRNPYMSVGAQVFP 414
            ||||     |...|        ||   :|.|...|.|..:..|
Human   170 PPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSP---------------------- 212

  Fly   415 LPPGQGFPWAHSTRG-KPRRGMM----------RRAVFSDSQRKGLEKRFQQQKYISKPDRKKLA 468
                   ||..:... .|.:|.:          .|..||..|...|||.|:|.||::.|:|.:||
Human   213 -------PWRDARLACTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLA 270

  Fly   469 ERLGLKDSQVKIWFQNRRMKWRNSKERELLASGGSRD-QTLPNKNNPNPDLSDAKCDRPLTPLS 531
            ..||:.:||||:||||||.|||.....|:..:...:| :|...|.....:..|...::||.|.|
Human   271 YSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKGASENEEEDDDYNKPLDPNS 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dbx	NP_647677.2	Homeodomain	437..491	CDD:459649	29/53 (55%)
NKX6-1	NP_006159.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..133		23/92 (25%)
		Repressor domain. /evidence=ECO:0000250	102..268		41/194 (21%)
		Homeodomain	235..293	CDD:459649	29/57 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..367		9/41 (22%)
		Involved in DNA-binding. /evidence=ECO:0000250	306..367		8/29 (28%)