Protein Alignment Dbx and NKX3-1

DIOPT Version :10

• Sequence 1: NP_647677.2
• Gene: Dbx / 38254
• FlyBaseID: FBgn0261723
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_006158.2
• Gene: NKX3-1 / 4824
• HGNCID: 7838
• Length: 234
• Species: Homo sapiens
• Alignment Length: 247
• Identity: 66/247 - (26%)
• Similarity: 94/247 - (38%)
• Gaps: 78/247 - (31%)

  Fly   312 DARPHELANSNPDEDSSASRRLT--------QDKQQQQQLLGAGGTGGGGGGGHGHGHPTPPPPP 368
            :.||.| |.:......:.|:.||        :|..|:|         ||.........|.|.|.|
Human     6 EPRPGE-AKAEGAAPPTPSKPLTSFLIQDILRDGAQRQ---------GGRTSSQRQRDPEPEPEP 60

  Fly   369 PP-------------------------PVIAKPMPSRPTPFLPHTLNHPHLHSLLAHCRNPYMSV 408
            .|                         ..:|:..|.|            ||.|.|....|   :.
Human    61 EPEGGRSRAGAQNDQLSTGPRAAPEEAETLAETEPER------------HLGSYLLDSEN---TS 110

  Fly   409 GAQVFPLPPGQGFPWAHSTRGKPRRGMMRRAVFSDSQRKGLEKRFQQQKYISKPDRKKLAERLGL 473
            ||          .|....|..:|::  ..||.||.:|...||::|..|||:|.|:|..||:.|.|
Human   111 GA----------LPRLPQTPKQPQK--RSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLKL 163

  Fly   474 KDSQVKIWFQNRRMKWRNSKERELLASGGSRDQTLPNKNNPNPDLSDAKCDR 525
            .::||||||||||.|   :|.::|.:..|..:     |::..|.|.:....|
Human   164 TETQVKIWFQNRRYK---TKRKQLSSELGDLE-----KHSSLPALKEEAFSR 207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dbx	NP_647677.2	Homeodomain	437..491	CDD:459649	29/53 (55%)
NKX3-1	NP_006158.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..131		32/161 (20%)
		Homeodomain	125..181	CDD:459649	29/60 (48%)