Protein Alignment Dbx and HHEX

DIOPT Version :10

• Sequence 1: NP_647677.2
• Gene: Dbx / 38254
• FlyBaseID: FBgn0261723
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_002720.1
• Gene: HHEX / 3087
• HGNCID: 4901
• Length: 270
• Species: Homo sapiens
• Alignment Length: 272
• Identity: 77/272 - (28%)
• Similarity: 103/272 - (37%)
• Gaps: 98/272 - (36%)

  Fly   356 GHGHGHPTPPPPPPPP-------------VIAKPMPSRPT-----------------------PF 384
            |.|...|||.|..|.|             .:.:|.|..|.                       ||
Human    39 GRGPAAPTPAPTLPSPNSSFTSLVSPYRTPVYEPTPIHPAFSHHSAAALAAAYGPGGFGGPLYPF 103

  Fly   385 LPHTLNHPHLHSLLAHCRNPYMSVGAQVFPLPPGQGFPWA-------HSTRGKPRRGMMRRAVFS 442
             |.|:| .:.|:||.|.              |.|:...|:       |..:|    |.:|   ||
Human   104 -PRTVN-DYTHALLRHD--------------PLGKPLLWSPFLQRPLHKRKG----GQVR---FS 145

  Fly   443 DSQRKGLEKRFQQQKYISKPDRKKLAERLGLKDSQVKIWFQNRRMKWR---------NSKER-EL 497
            :.|...|||:|:.|||:|.|:||:||:.|.|.:.|||.||||||.|||         |.||. |.
Human   146 NDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKEELES 210

  Fly   498 LASGGSRDQTLPNKNNPNPDLSDAKCDRPLTPLSPSLLSPNGSATPPPPGAVAKDEPPTAAVTPK 562
            |.|...:.|.||::.|....|..::|                  :|.|    |..|...:.::..
Human   211 LDSSCDQRQDLPSEQNKGASLDSSQC------------------SPSP----ASQEDLESEISED 253

  Fly   563 SPQSVSSRSSPS 574
            |.|.|......|
Human   254 SDQEVDIEGDKS 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dbx	NP_647677.2	Homeodomain	437..491	CDD:459649	31/62 (50%)
HHEX	NP_002720.1	Interaction with SOX13. /evidence=ECO:0000269|PubMed:20028982	1..137		24/113 (21%)
		Homeodomain	136..194	CDD:459649	32/64 (50%)
		Required for WNT signaling induction. /evidence=ECO:0000269|PubMed:20028982	137..270		53/158 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..270		20/94 (21%)