Protein Alignment Dbx and Pdx1

DIOPT Version :10

• Sequence 1: NP_647677.2
• Gene: Dbx / 38254
• FlyBaseID: FBgn0261723
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_074043.4
• Gene: Pdx1 / 29535
• RGDID: 62387
• Length: 283
• Species: Rattus norvegicus
• Alignment Length: 262
• Identity: 75/262 - (28%)
• Similarity: 99/262 - (37%)
• Gaps: 83/262 - (31%)

  Fly   365 PPPPPPPVIAKPM-------PSRPTPF-LPHTLNHP---HLHSL------LAHCRNPYMSVGAQV 412
            |||||||..|..:       |...:|: :|...:.|   |||..      |||
  Rat    42 PPPPPPPQFAGSLGTLEQGSPPDISPYEVPPLADDPAGAHLHHHLPAQLGLAH------------ 94

  Fly   413 FPLPPGQ------------------GFPWAHSTR--------------GKPRRGMMRRAVFSDSQ 445
             | |||.                  .|||..||:              .:|......|..::.:|
  Rat    95 -P-PPGPFPNGTETGGLEEPSRVHLPFPWMKSTKAHAWKSQWAGGAYAAEPEENKRTRTAYTRAQ 157

  Fly   446 RKGLEKRFQQQKYISKPDRKKLAERLGLKDSQVKIWFQNRRMKWRNSKEREL---LASGGSRDQT 507
            ...|||.|...||||:|.|.:||..|.|.:..:|||||||||||:..::::.   ..|||...:
  Rat   158 LLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTTSGGGGGE- 221

  Fly   508 LPNKNNPNPDLSDAKCDRPLTPLSPSLLSPNGSATPPPPGAVAKDEPPTAAVTPKSPQSVSSRSS 572
                 .|..|.: ......|..|.|          |||||.......|.||...:.|..:|:...
  Rat   222 -----EPEQDCA-VTSGEELLALPP----------PPPPGGAVPSGVPAAAREGRLPSGLSASPQ 270

  Fly   573 PS 574
            ||
  Rat   271 PS 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dbx	NP_647677.2	Homeodomain	437..491	CDD:459649	27/53 (51%)
Pdx1	NP_074043.4	Transactivation domain	13..73		11/30 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..81		12/38 (32%)
		Antp-type hexapeptide	118..123		3/4 (75%)
		Homeodomain	147..203	CDD:459649	27/55 (49%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		5/5 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		21/89 (24%)