Protein Alignment Dbx and CDX2

DIOPT Version :10

• Sequence 1: NP_647677.2
• Gene: Dbx / 38254
• FlyBaseID: FBgn0261723
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: XP_011533177.1
• Gene: CDX2 / 1045
• HGNCID: 1806
• Length: 321
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 81/300 - (27%)
• Similarity: 109/300 - (36%)
• Gaps: 61/300 - (20%)

  Fly   279 SSSSPGSTISDSDNNHGASTA---NGNGSGTGNSGQDARPHELANSNPDEDSSASRRLTQDKQQQ 340
            |:.|||.:...:   :||...   ||...|...:..:|..|.|...:|
Human    57 SAQSPGPSWPAA---YGAPLREDWNGYAPGGAAAAANAVAHGLNGGSP----------------- 101

  Fly   341 QQLLGAGGTGGGGGGGHGHGHPTPP---------------PPPPPPVIAKPMPSRPTPFLPHTLN 390
            ...:|...........|.|.||..|               |.||.|. |.....:.:|
Human   102 AAAMGYSSPADYHPHHHPHHHPHHPAAAPSCASGLLQTLNPGPPGPA-ATAAAEQLSP------- 158

  Fly   391 HPHLHSLLAHCRNP-YMSVGAQVFPLPPGQGFPWAHSTRGKPRRGMMRRAVFSDSQRKGLEKRFQ 454
            .....:|....|.| ..|:|:|....|         |:..|.|.....|.|::|.||..|||.|.
Human   159 GGQRRNLCEWMRKPAQQSLGSQALTSP---------SSTVKTRTKDKYRVVYTDHQRLELEKEFH 214

  Fly   455 QQKYISKPDRKKLAERLGLKDSQVKIWFQNRRMKWRNSKERELLASGGSRDQTLPNKNNPNPDLS 519
            ..:||:...:.:||..|||.:.||||||||||.|.|...:::|    ..:.|..|.:..|.|...
Human   215 YSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKKKL----QQQQQQQPPQPPPPPPQP 275

  Fly   520 DAKCDRPLTPLSPSLLSPNGSATPPPPGAVAKDEPPTAAV 559
            ......||..: |..|||..|.....||:|.....||..|
Human   276 PQPQPGPLRSV-PEPLSPVSSLQASVPGSVPGVLGPTGGV 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dbx	NP_647677.2	Homeodomain	437..491	CDD:459649	27/53 (51%)
CDX2	XP_011533177.1	Caudal_act	13..179	CDD:461413	29/149 (19%)
		Homeodomain	196..251	CDD:459649	27/54 (50%)