DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsb and SCARB2

DIOPT Version :9

Sequence 1:	NP_001097477.1	Gene:	dsb / 38252	FlyBaseID:	FBgn0035290	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_005497.1	Gene:	SCARB2 / 950	HGNCID:	1665	Length:	478	Species:	Homo sapiens

Alignment Length:	461	Identity:	145/461 - (31%)
Similarity:	238/461 - (51%)	Gaps:	29/461 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 VIIIGIITLILGIILSSMPWLDYFILKNLRLWNDTLSYHYWQRPGVIRLTKLYIYNVTNPDGFLR 146
            ::::..:||::..:....  :|..|.|.:.|.|.|.::..|::|.:...|:.|.:|||||:..||
Human    15 LLLVTSVTLLVARVFQKA--VDQSIEKKIVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEILR 77

  Fly   147 GEKPHLQEVGPFVYREDMQKVNVKFHENNYTVSYQHKKILQFVPELSI--DKDTPITTPNIPLLT 209
            ||.|.::||||:.|||...|.|::|.:|..|:|....|...|..:.|:  .|...|.|.|||:||
Human    78 GETPRVEEVGPYTYRELRNKANIQFGDNGTTISAVSNKAYVFERDQSVGDPKIDLIRTLNIPVLT 142

  Fly   210 LTSLSPKLGYLLSKTISVVVTAAQFKPFINVTAEQLAFGYDDALVSLAHRFYPKHMRPMERMGLL 274
            :...|..  :.|.:.|..::.|.|.|.|:..|.::|.:||.|.::||.|.|.| .:.|.  .||.
Human   143 VIEWSQV--HFLREIIEAMLKAYQQKLFVTHTVDELLWGYKDEILSLIHVFRP-DISPY--FGLF 202

  Fly   275 LGRNGTLTEVSSVKTGMDSMDQFGYIDQLNGLDHLPHWSEPPCTSIAGSEGSFFPPRELTKSEVV 339
            ..:|||........||.||...|..|.:.||...|..|....|..|.|::|..|.|. :||.||:
Human   203 YEKNGTNDGDYVFLTGEDSYLNFTKIVEWNGKTSLDWWITDKCNMINGTDGDSFHPL-ITKDEVL 266

  Fly   340 HIYDKDLCRIIPLKYVESLEKDGIAADLFRLPNNSYGDSAHN-----PENKCYDTSEYEPIQGLQ 399
            :::..|.||.:.:.:.:.....|:.|..:::|.....:::.|     ||..|..:       |:.
Human   267 YVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILANTSDNAGFCIPEGNCLGS-------GVL 324

  Fly   400 NISPCQYGAPVYISNPHFFESHPDLLNSVEGLKPEREKHETYFKIQPKLGVPLEGKVRIQLNLKV 464
            |:|.|:.|||:.:|.|||:::....::::||:.|.:|.|||:..|.|..|:.|:...|.|:|:.|
Human   325 NVSICKNGAPIIMSFPHFYQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKAAKRFQINIYV 389

  Fly   465 TRAKDVYPVRDFRDFVFPVMWLEEGI---SELTPAIKRWIYLGTVIAPSAVPIGSYLMILGGAFA 526
            .:..|.....|.|..|||||:|.|.:   .|....:|..|  .|.:..:.:|.  .:|.||..|.
Human   390 KKLDDFVETGDIRTMVFPVMYLNESVHIDKETASRLKSMI--NTTLIITNIPY--IIMALGVFFG 450

  Fly   527 IIFSFV 532
            ::|:::
Human   451 LVFTWL 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsb	NP_001097477.1	CD36	103..532	CDD:279474	143/438 (33%)
SCARB2	NP_005497.1	CD36	28..455	CDD:307331	143/445 (32%)
SCARB2	NP_005497.1	Important for interaction with GBA	155..191		13/35 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2115
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5605
OMA	1	1.010	-	-		QHG45589
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	1	1.000	-	-		FOG0000618
OrthoInspector	1	1.000	-	-		mtm8581
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.880