DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsb and CD36

DIOPT Version :9

Sequence 1:	NP_001097477.1	Gene:	dsb / 38252	FlyBaseID:	FBgn0035290	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_000063.2	Gene:	CD36 / 948	HGNCID:	1663	Length:	472	Species:	Homo sapiens

Alignment Length:	423	Identity:	121/423 - (28%)
Similarity:	203/423 - (47%)	Gaps:	28/423 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LAVIIIGIITLILGIILSSMPWLDYFILKNLR----LWNDTLSYHYWQRPGVIRLTKLYIYNVTN 140
            :|..:||.:..:.|.||  ||..|..|.|.::    |...|:::..|.:.|.....:.:|::|.|
Human    10 IAGAVIGAVLAVFGGIL--MPVGDLLIQKTIKKQVVLEEGTIAFKNWVKTGTEVYRQFWIFDVQN 72

  Fly   141 P-DGFLRGEKPHLQEVGPFVYR-EDMQKVNVKFHENNYTVSYQHKKILQFVPELSIDKDTPITTP 203
            | :..:......:::.||:.|| ..:.|.||.....:.|||:.......|.|.||:..:    ..
Human    73 PQEVMMNSSNIQVKQRGPYTYRVRFLAKENVTQDAEDNTVSFLQPNGAIFEPSLSVGTE----AD 133

  Fly   204 NIPLLTLTSLSPKLGY---LLSKTISVVVTAAQFKPFINVTAEQLAFGYDDALVSLAHRFYPKHM 265
            |..:|.|...:....|   .:...::.::..::...|...|..:|.:||.|..:||..  ||
Human   134 NFTVLNLAVAAASHIYQNQFVQMILNSLINKSKSSMFQVRTLRELLWGYRDPFLSLVP--YP--- 193

  Fly   266 RPMERMGLLLGRNGTLTEVSSVKTGMDSMDQFGYIDQLNGLDHLPHWSEPPCTSIAGSEGSFFPP 330
             ....:||....|.|...|..|..|.|::.:...||...|..:|.:| |..|..|.|::.:.|||
Human   194 -VTTTVGLFYPYNNTADGVYKVFNGKDNISKVAIIDTYKGKRNLSYW-ESHCDMINGTDAASFPP 256

  Fly   331 RELTKSEVVHIYDKDLCRIIPLKYVESLEKDGIAADLFRLPNNSYGDSAHNPENKCYDT----SE 391
             .:.||:|:..:..|:||.|...:...:...||....|.||:.::.....||:|.|:.|    |:
Human   257 -FVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVYRFVLPSKAFASPVENPDNYCFCTEKIISK 320

  Fly   392 YEPIQGLQNISPCQYGAPVYISNPHFFESHPDLLNSVEGLKPEREKHETYFKIQPKLGVPLEGKV 456
            .....|:.:||.|:.|.|||||.|||..:.||:...::||.|..|:|.||..|:|..|..|:...
Human   321 NCTSYGVLDISKCKEGRPVYISLPHFLYASPDVSEPIDGLNPNEEEHRTYLDIEPITGFTLQFAK 385

  Fly   457 RIQLNLKVTRAKDVYPVRDF-RDFVFPVMWLEE 488
            |:|:||.|..::.:..:::. |:::.|::||.|
Human   386 RLQVNLLVKPSEKIQVLKNLKRNYIVPILWLNE 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsb	NP_001097477.1	CD36	103..532	CDD:279474	113/400 (28%)
CD36	NP_000063.2	CD36	14..463	CDD:395898	120/419 (29%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000269\|PubMed:1371676	93..120		8/26 (31%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000269\|PubMed:20037584	460..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	1	1.000	-	-		FOG0000618
OrthoInspector	1	1.000	-	-		mtm8581
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820