DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsb and CG40006

DIOPT Version :9

Sequence 1:	NP_001097477.1	Gene:	dsb / 38252	FlyBaseID:	FBgn0035290	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001036401.1	Gene:	CG40006 / 3355123	FlyBaseID:	FBgn0058006	Length:	689	Species:	Drosophila melanogaster

Alignment Length:	586	Identity:	151/586 - (25%)
Similarity:	266/586 - (45%)	Gaps:	76/586 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RYGRTARDHLLDWATCGRGRRQQQQQQQQQTHAQPSQGSTATG----------------RRSRPH 57
            ||...:||              .:...|:|:...|..|.:...                ||....
  Fly    11 RYSSVSRD--------------VEASNQRQSAVTPGSGLSTDADPAVSCAAQVALQRIQRRKSLK 61

  Fly    58 VTHRGTPLSMLIS---NGVRISNNRL-----AVIIIGIITLILGIILSSMPWLDYFILKNLRLWN 114
            ......|:.:|.|   ..::...||:     .:::||.:.:|...::..:...|......|.:..
  Fly    62 ANRSMNPIDILSSFFNEPIQGKRNRVPTRLFILLVIGFLAIITSTLIKVLEPYDLIFKWKLIMTE 126

  Fly   115 DTLSYHYWQRPGVIRLTKLYIYNVTNPDGFLRG-EKPHLQEVGPFVYREDMQKVNVKFHENNYTV 178
            ....::.|.:|.|....|:|::|:||.:.||.| |:..:::|||:||:|.|...||.|:.|| |:
  Fly   127 GGEIFNLWAQPPVDLYIKIYLFNITNANAFLAGREQLRVEQVGPYVYKEIMTHENVTFNSNN-TM 190

  Fly   179 SYQHKKILQFVPELS--IDKDTPITTPNIPLLTLTSLSPKLGYLLSKTISVVVTAAQFKPFINVT 241
            |......|.:..|:|  ..:|..:...||.:|.::.|:....:|:...:..::.:.:.:|.:..|
  Fly   191 SSTPSHPLVWQEEMSGNCREDDEVVMLNIAMLAISHLTANQPFLVRMALKTLLLSTKSEPIVRTT 255

  Fly   242 AEQLAFGYDDALVSLAHRFYPKHMRPMERMGLLLGRNGTLTEVSSVKTGMDSMDQFGYIDQLNGL 306
            |::..|||..||.:|.:.|.|..: ..|::||:.......|:..:..||:.:....|......|.
  Fly   256 AKEFMFGYPSALATLGNTFLPNWI-SFEKVGLIDRMYDFSTDFETFYTGVPNPALSGLYASYRGE 319

  Fly   307 DHLPHWSEPPCTSIA-GSEG----SFFPPRELTKSEVVHIYDKDLCRIIPLKYVESLEKDG-IAA 365
            ..||.|....|::|. .|:|    ||..|     :|.|..:.|.:||.|.|..|.:.:..| :..
  Fly   320 TTLPQWDGDHCSNIEFASDGTKFKSFIQP-----NETVKFFRKSMCRPINLYRVGNEKTYGSLKG 379

  Fly   366 DLFRLPNNSYGDSAHNPENKCY-DTSEYEPIQGLQNISPCQYGAPVYISNPHFFESHPDLLNSVE 429
            ..:...:|::.:.|.|..|||: ...:.:|: ||.:::.|.||.|:.:|.|||......|..:|.
  Fly   380 YNYVFEDNAFDNGATNEANKCFCRKGDCQPV-GLIDVTDCYYGFPISLSFPHFMNGDVGLQQNVT 443

  Fly   430 GLKPEREKHETYFKIQPKLGVPLEGKVRIQLNLKVTRAKDV--YPVRD-FRDFVFPVMWLEEGIS 491
            |:.|:.:||.:.|.|||:.|:||...|::|:|:   ..||:  :||.. |.....|::|.|..:|
  Fly   444 GISPDPDKHSSTFVIQPESGLPLSLSVKVQINM---HFKDLSNFPVVSVFNHLTVPMLWFEIMMS 505

  Fly   492 ELTPAI-KRW-IYLGTVIAPSAVPIGSYLMILGGAFAIIFSFVRAYQNFMFAQDPTLEILEMGRR 554
            :|..:: .|: .||.  |.|...|:|.:..||.|...:.::..:|          ||.:....||
  Fly   506 KLPDSLDSRFNFYLN--ILPLVNPLGFWSGILLGISLLGYAITKA----------TLHMSTFSRR 558

  Fly   555 S 555
            :
  Fly   559 A 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsb	NP_001097477.1	CD36	103..532	CDD:279474	128/443 (29%)
CG40006	NP_001036401.1	CD36	91..545	CDD:279474	131/466 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450690
Domainoid	1	1.000	168	1.000	Domainoid score	I2304
eggNOG	1	0.900	-	-		E1_KOG3776
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I2746
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11923
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900