DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsb and Cd36

DIOPT Version :9

Sequence 1:	NP_001097477.1	Gene:	dsb / 38252	FlyBaseID:	FBgn0035290	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_113749.2	Gene:	Cd36 / 29184	RGDID:	2301	Length:	472	Species:	Rattus norvegicus

Alignment Length:	481	Identity:	127/481 - (26%)
Similarity:	223/481 - (46%)	Gaps:	60/481 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 IIGIITLILGIILSSMPWLDYFILKNLR----LWNDTLSYHYWQRPGVIRLTKLYIYNVTNPDGF 144
            :||.:..:.|.||  ||..|..|.|.::    |...|:::..|.:.|.....:.:|::|.||:..
  Rat    14 VIGAVLAVFGGIL--MPVGDLLIEKTIKREVVLEEGTIAFKNWVKTGTTVYRQFWIFDVQNPEEV 76

  Fly   145 LR-GEKPHLQEVGPFVYR-EDMQKVNVKFHENNYTVSYQHKKILQFVPELSIDKDTPITTPNIPL 207
            .: ..|..:::.||:.|| ..:.|.|:.....:.|||:.......|.|.||:..:    ..|..:
  Rat    77 AKNSSKIKVKQRGPYTYRVRYLAKENITQDPKDSTVSFVQPNGAIFEPSLSVGTE----NDNFTV 137

  Fly   208 LTL-TSLSPKL--GYLLSKTISVVVTAAQFKPFINVTAEQLAFGYDDALVSLAHRFYPKHMRPME 269
            |.| .:.:|.:  ...:...::.::..::...|...:.::|.:||.|..:||..  ||    ...
  Rat   138 LNLAVAAAPHIYTNSFVQGVLNSLIKKSKSSMFQTRSLKELLWGYKDPFLSLVP--YP----IST 196

  Fly   270 RMGLLLGRNGTLTEVSSVKTGMDSMDQFGYIDQLNGLDHLPHWSEPPCTSIAGSEGSFFPPRELT 334
            .:|:....|.|:..|..|..|.|::.:...||...|..:|.:| |..|..|.|::.:.||| .:.
  Rat   197 TVGVFYPYNNTVDGVYKVFNGKDNISKVAIIDTYKGKRNLSYW-ESYCDMINGTDAASFPP-FVE 259

  Fly   335 KSEVVHIYDKDLCRIIPLKYVESLEKDGIAADLFRLPNNSYGDSAHNPENKCYDT--------SE 391
            ||..:..:..|:||.|...:...:...||....|.||.|::.....||:|.|:.|        :.
  Rat   260 KSRTLRFFSSDICRSIYAVFGSEVNLKGIPVYRFVLPANAFASPLQNPDNHCFCTEKVISNNCTS 324

  Fly   392 YEPIQGLQNISPCQYGAPVYISNPHFFESHPDLLNSVEGLKPEREKHETYFKIQPKLGVPLEGKV 456
            |    |:.:|..|:.|.|||||.|||..:.||:...:|||.|..::|.||..::|..|..|:...
  Rat   325 Y----GVLDIGKCKEGKPVYISLPHFLHASPDVSEPIEGLNPNEDEHRTYLDVEPITGFTLQFAK 385

  Fly   457 RIQLNLKVTRAKDVYPVRDF-RDFVFPVMWLEE-GI----------SELTPAIKRWIYLGTVIAP 509
            |:|:|:.|..|:.:..:::. |.::.|::||.| |.          :::|..||   .||.|
  Rat   386 RLQVNILVKPARKIEALKNLKRPYIVPILWLNETGTIGDEKAEMFRNQVTGKIK---LLGLV--- 444

  Fly   510 SAVPIGSYLMILGGAFAIIFSFVRAY 535
                   .:::||....:..:|:.:|
  Rat   445 -------EMVLLGVGVVMFVAFMISY 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsb	NP_001097477.1	CD36	103..532	CDD:279474	118/457 (26%)
Cd36	NP_113749.2	CD36	14..463	CDD:395898	126/479 (26%)
		Required for interaction with thrombospondins, THBS1 and THBS2. /evidence=ECO:0000250	93..120		7/26 (27%)
		Interaction with PTK2, PXN and LYN. /evidence=ECO:0000250\|UniProtKB:P16671	460..472		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	1	1.000	-	-		FOG0000618
OrthoInspector	1	1.000	-	-		mtm9056
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920