DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dsb and scav-2

DIOPT Version :9

Sequence 1:	NP_001097477.1	Gene:	dsb / 38252	FlyBaseID:	FBgn0035290	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_499802.3	Gene:	scav-2 / 176787	WormBaseID:	WBGene00013578	Length:	558	Species:	Caenorhabditis elegans

Alignment Length:	577	Identity:	151/577 - (26%)
Similarity:	250/577 - (43%)	Gaps:	110/577 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PSQGSTATGRRSRPHVTHRGTPLSMLISNG--VRISNNRLAV--IIIGIITLIL----------- 92
            ||..:::.|..|       .:|::...|:|  .|:|..:|.:  ::||:.:.:|
Worm     2 PSSNNSSNGASS-------SSPIASKYSSGRMRRMSCCQLVISAVLIGLGSFLLFGSLITHTVVV 59

  Fly    93 -GIILSSMPWLDYFILKNLRLWNDTLSYHYWQRPGVIRLTKLYIYNVTNPDGFLRGEKPHLQEVG 156
             .::.||       |.:|.||.|.::.:..|..|.......:|:|:..|||.|:.|..|.:...|
Worm    60 PKVVKSS-------IEENSRLVNGSIMWEKWAMPEYKIRFNMYVYSTKNPDEFMNGAIPEVTGSG 117

  Fly   157 PFVYREDMQKVNVKFHENNYTVSYQHKKILQFVPELSIDK---DTPITTPNIPLLTLTSLSPKLG 218
            |:|:.:.|:  |......|.||.|:......|..:.|...   ...|..||:........:...|
Worm   118 PYVFDKKME--NRVVSAENGTVKYRRFFTYNFNEQESCQTCILGNRIWVPNMIYQKFVEAASTEG 180

  Fly   219 YLLSKTISVVVTAAQFKPFINVTAEQLAF-GYDD-----------------ALVSLAHRFYPKHM 265
            ...:.|..:..||     |:.|..|:|.| ||.|                 |::.:.
Worm   181 MKAAATTLLSQTA-----FLEVEVEELLFEGYKDPFLDKVCEIPFMNFVCEAILDVP-------- 232

  Fly   266 RPMERMGLLLGRNGTLTEVSSVKTGMDSMDQFGYI---DQLNGLDHLPHWSEPPCTSIAGSEGSF 327
               ||:||....|||.::|..:..|..:.|..|.|   |:...||. ..||......|.|::||.
Worm   233 ---ERIGLFFKANGTGSKVYEIDDGTRNPDDLGKILSYDESPILDE-TWWSTDESLKIKGTDGSL 293

  Fly   328 FPPRELTKSEVVHIYDKDLCRIIPLKYVESLEKDGIAADLFRLPNNSYGDSAH-------NPENK 385
            |.| .|:|.|.:::|..:|||.|.|::.|.:|..|:.|..|.:|...: |..|       ||..|
Worm   294 FHP-FLSKHEKLYVYVAELCRSIWLEFKEEVEYRGLKAYRFVVPPEVF-DVTHPGNQGFCNPSEK 356

  Fly   386 CY-----DTSEYEPIQGLQNISPCQYG-APVYISNPHFFESHPDLLNSVEGLKPERE-KHETYFK 443
            .:     |:|...| :||..||.||.. .|:.||.|:|..:..::..||:||....| :......
Worm   357 QFYESQNDSSNCMP-KGLLEISKCQQSQPPITISLPNFLFAPSEVRGSVKGLNETDEIRDSIVVD 420

  Fly   444 IQPKLGVPLEGKVRIQLNLKVTRAKDV-YPV--RDFRDFVFPVMWLEEGISEL----TPAIKRWI 501
            |:|::|..|..:...|:|:::.:.|:: :||  :..:..:.||:.|.| .||:    ...|:..:
Worm   421 IEPRVGAVLYARRVSQVNIEMWKGKNLTFPVNLKKMKSALIPVLILHE-TSEIDDDSLEQIRSQL 484

  Fly   502 YLGTVIAPSAVPIGSYLMILGGAFAIIFSFVRAYQNFMFAQ-DPTLEILEMGRRSLR 557
            |....||.::..:    |::.||..::..|:  :.:|.... ||.|     ||||.|
Worm   485 YETESIAYTSCDV----MMIIGAIMLLLGFL--FLSFSLGLCDPIL-----GRRSKR 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dsb	NP_001097477.1	CD36	103..532	CDD:279474	126/473 (27%)
scav-2	NP_499802.3	CD36	46..505	CDD:279474	129/492 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	168	1.000	Domainoid score	I2304
eggNOG	1	0.900	-	-		E1_KOG3776
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I2746
Isobase	1	0.950	-	0	Normalized mean entropy	S5605
OMA	1	1.010	-	-		QHG45589
OrthoDB	1	1.010	-	-		D1106566at2759
OrthoFinder	1	1.000	-	-		FOG0000618
OrthoInspector	1	1.000	-	-		mtm4750
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11923
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X155
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.930