Protein Alignment dre4 and Supt16

DIOPT Version :10

• Sequence 1: NP_476610.2
• Gene: dre4 / 38248
• FlyBaseID: FBgn0002183
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_291096.2
• Gene: Supt16 / 114741
• MGIID: 1890948
• Length: 1047
• Species: Mus musculus
• Alignment Length: 1079
• Identity: 635/1079 - (58%)
• Similarity: 819/1079 - (75%)
• Gaps: 43/1079 - (3%)

  Fly     6 LDKEAFVRRVKRLYTEWRAPSIGHDDALRNLDCIMSIVGVEEDVMYSKSMALQLWLLGYELTDTI 70
            |||:|:.|||||||:.||.    .:|...::|.|:..|||:|:::|:||.|||.||.||||||||
Mouse     5 LDKDAYYRRVKRLYSNWRK----GEDEYASIDAIVVSVGVDEEIVYAKSTALQTWLFGYELTDTI 65

  Fly    71 SVFCSDAVYFLTSKKKIEFLKQTQNI----TEEGFPEINLLVRDRTDKDQGNFEKLIKALQNSKK 131
            .|||.|.:.|:.||||:|||||..|.    ...|.|.|.||||::.:.::.:|:|:|.|::.||.
Mouse    66 MVFCDDKIIFMASKKKVEFLKQIANTKGNENANGAPAITLLVREKNESNKSSFDKMIDAIKESKS 130

  Fly   132 GKRLGVFAKDAYPGEFSEAWKKSLTASKFEHVDISTIIAYLMCPKDESEINNIRKASLVSMDIFN 196
            ||::|||:||.:||||.::|...|....|:.||||.::||.:..|::.|:|.::||:.::.::||
Mouse   131 GKKIGVFSKDKFPGEFMKSWSDCLNKEGFDKVDISAVVAYTIAVKEDGELNLMKKAASITSEVFN 195

  Fly   197 KYLKDEIMDIIDSDRKVKHNKLSDGCEAAIGEKKYTSGLDPRLLDMAYPPIIQSGGAYSLKFSAV 261
            |:.|:.:|:|:|:|.||:|:||::..|.||.||||.:|.||..::|.|||||||||.|:||||.|
Mouse   196 KFFKERVMEIVDADEKVRHSKLAESVEKAIEEKKYLAGADPSTVEMCYPPIIQSGGNYNLKFSVV 260

  Fly   262 ADKNPLHFGVIVCSLGARYKSYCSNISRTFLVNPTEAMQENYTFLVSVQEEILKLLVPGTKLCDV 326
            :|||.:|||.|.|::|.|:||||||:.||.:|:||:.:||||.||:.:|||:||.|..|.|:|||
Mouse   261 SDKNHMHFGAITCAMGIRFKSYCSNLVRTLMVDPTQEVQENYNFLLQLQEELLKELRHGVKICDV 325

  Fly   327 YEKTLDFVKKEKPSMVDNLPKSFGFAMGLEFRENSIVIGPKCQALLKKNMVFNLHVGISNLTNPE 391
            |...:|.|||:||.:::.:.|:.||.||:||||.|:||..|.|..|||.|||::::|.|:|||.|
Mouse   326 YNSVMDVVKKQKPELLNKITKNLGFGMGIEFREGSLVINSKNQYKLKKGMVFSINLGFSDLTNKE 390

  Fly   392 ATDKEGKNYALFIGDTVLVGEQSPASVMTPSKKKIKNVGIFIKDDSDEEDVDDKKTAKEDQGTEI 456
            ....|.|.|||||||||||.|..||:::|..|||:||||||:|::.|||:.::|     |:..::
Mouse   391 GKKPEEKTYALFIGDTVLVDEDGPATILTSVKKKVKNVGIFLKNEDDEEEEEEK-----DEAEDL 450

  Fly   457 LGRSKRNAVLESKLRNEINTEEKRKEHQRELAQQLNERAKDRLARQGNSKEVEKVRKNTVSYKSI 521
            |||..|.|:|..:.|||:..||||:.||:|||.||||.||.||..|...::::|.||:.||||:.
Mouse   451 LGRGSRAALLTERTRNEMTAEEKRRAHQKELAAQLNEEAKRRLTEQKGEQQIQKARKSNVSYKNP 515

  Fly   522 SQMPREPEVKELKLYVDKKYETVIMPVFGIQVPFHISTIKNISQSVEGEYTYLRINFFHPGATMG 586
            |.||:||.::|:|:|:||||||||||||||..||||:||||||.||||:||||||||:.||:.:|
Mouse   516 SLMPKEPHIREMKIYIDKKYETVIMPVFGIATPFHIATIKNISMSVEGDYTYLRINFYCPGSALG 580

  Fly   587 RNEGGLYPQPEATFVKEVTYRSSNVKEHGEVGAPSANLNNAFRLIKEVQKRFKTREAEEREKEDL 651
            ||||.::|.||||||||:|||:||:|..||...|:.||.||||:|||||||:|||||||:|||.:
Mouse   581 RNEGNIFPNPEATFVKEITYRASNMKAPGEQTVPALNLQNAFRIIKEVQKRYKTREAEEKEKEGI 645

  Fly   652 VKQDTLILSQNKGNPKLKDLYIRPNIVTKRMTGSLEAHSNGFRYISVRGDKVDILYNNIKSAFFQ 716
            ||||:|:::.|:.|||||||||||||..|||.||||||.||||:.|||||||||||||||.|.||
Mouse   646 VKQDSLVINLNRSNPKLKDLYIRPNIAQKRMQGSLEAHVNGFRFTSVRGDKVDILYNNIKHALFQ 710

  Fly   717 PCDGEMIILLHFHLKYAIMFGKKKHVDVQFYTEVGEITTDLGKHQHMHDRDDLAAEQAERELRHK 781
            ||||||||:||||||.|||||||:|.|||||||||||||||||||||||||||.|||.|||:|||
Mouse   711 PCDGEMIIVLHFHLKNAIMFGKKRHTDVQFYTEVGEITTDLGKHQHMHDRDDLYAEQMEREMRHK 775

  Fly   782 LKTAFKSFCEKVETMTKSVVEFDTPFRELGFPGAPFRSTVTLQPTSGSLVNLTEWPPFVITLDDV 846
            ||||||:|.||||.:||..:||:.|||:|||.|||:|||..|||||.:|||.|||||||:|||:|
Mouse   776 LKTAFKNFIEKVEALTKEELEFEVPFRDLGFNGAPYRSTCLLQPTSSALVNATEWPPFVVTLDEV 840

  Fly   847 ELVHFERVQFHLRNFDMIFVFKEYNKKVAMVNAIPMNMLDHVKEWLNSCDIRYSEGVQSLNWQKI 911
            ||:|||||||||:||||:.|:|:|:|||.|:||||:..||.:||||||||::|:||||||||.||
Mouse   841 ELIHFERVQFHLKNFDMVIVYKDYSKKVTMINAIPVASLDPIKEWLNSCDLKYTEGVQSLNWTKI 905

  Fly   912 MKTITDDPEGFFEQGGWTFLDPE-SGSEGENETAESE-EDEAYNPT-DAESDEESDEDSEYSEAS 973
            ||||.||||||||||||:||:|| .||:.|:..:||| |||.:||: |...:||.|.|.:||..:
Mouse   906 MKTIVDDPEGFFEQGGWSFLEPEGEGSDAEDGDSESEIEDETFNPSEDDYEEEEEDSDEDYSSEA 970

  Fly   974 EDSEESDEDLGSDEESGKDWSDLEREAAEEDRNHDYAADDKPRNGKFDSKKHGKSSKHSRRDREE 1038
            |:|:.|.|.|||:|||||||.:||.||.:.||                         .||.:.||
Mouse   971 EESDYSKESLGSEEESGKDWDELEEEARKADR-------------------------ESRYEEEE 1010

  Fly  1039 ARSSSHSKKHKSNSSSSSSHLKSSSSKHGSSSSPSKSSK 1077
            .:|.|.|:|.|: |..||....:..|:| ||:.|.|..|
Mouse  1011 EQSRSMSRKRKA-SVHSSGRGSNRGSRH-SSAPPKKKRK 1047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dre4	NP_476610.2	COG5406	1..1005	CDD:227693	614/1005 (61%)
Supt16	NP_291096.2	COG5406	5..1001	CDD:227693	614/1004 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	491..518		11/26 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	918..1047		65/155 (42%)