DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12020 and DNAJB14

DIOPT Version :9

Sequence 1:	NP_647662.1	Gene:	CG12020 / 38233	FlyBaseID:	FBgn0035273	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_001026893.1	Gene:	DNAJB14 / 79982	HGNCID:	25881	Length:	379	Species:	Homo sapiens

Alignment Length:	282	Identity:	62/282 - (21%)
Similarity:	95/282 - (33%)	Gaps:	111/282 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DYYAVLDQPRGATKEQITLAYRRLAIRLCPHRDKKDEQDFVPLAQEGRLTHLSPMGEPRQWAYVN 71
            :||.||...:.|..|.:..|||:||::.  |.||..                :| |....:..:.
Human   108 NYYEVLGVTKDAGDEDLKKAYRKLALKF--HPDKNH----------------AP-GATDAFKKIG 153

  Fly    72 MAFDVLGNDLYRAIYDRFG--------------------EA--------GLFEGVMLPN------ 102
            .|:.||.|...|..||..|                    ||        .:|.|...|:
Human   154 NAYAVLSNPEKRKQYDLTGNEEQACNHQNNGRFNFHRGCEADITPEDLFNIFFGGGFPSGSVHSF 218

  Fly   103 -----GYFPPYQY-DGDHMKVYERVFGSYSPYANVIDAI-------------SNPP-SLYATRQH 147
                 ||...:|: ...|.:..||..|.:|.:..::..|             |||| |||.....
Human   219 SNGRAGYSQQHQHRHSGHEREEERGDGGFSVFIQLMPIIVLILVSLLSQLMVSNPPYSLYPRSGT 283

  Fly   148 GIGVR------------SKDASTE------RIIELSLEE-----VRTGCVKLMNVW--RQEIVDA 187
            |..::            :||...|      :.:|.|:||     :|..|      |  ||:..|.
Human   284 GQTIKMQTENLGVVYYVNKDFKNEYKGMLLQKVEKSVEEDYVTNIRNNC------WKERQQKTDM 342

  Fly   188 -------KESRLEKRKHTLKLN 202
                   ::.||.::...|.::
Human   343 QYAAKVYRDDRLRRKADALSMD 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12020	NP_647662.1	DnaJ	7..352	CDD:223560	62/282 (22%)
		DnaJ	7..87	CDD:278647	21/79 (27%)
		DnaJ_C	156..335	CDD:199909	14/67 (21%)
DNAJB14	NP_001026893.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..94
		DnaJ	107..>214	CDD:223560	29/124 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..241		4/21 (19%)
		DUF1977	271..371	CDD:370429	24/100 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810