DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12020 and DNAJA1

DIOPT Version :9

Sequence 1:	NP_647662.1	Gene:	CG12020 / 38233	FlyBaseID:	FBgn0035273	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_001530.1	Gene:	DNAJA1 / 3301	HGNCID:	5229	Length:	397	Species:	Homo sapiens

Alignment Length:	409	Identity:	109/409 - (26%)
Similarity:	172/409 - (42%)	Gaps:	98/409 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ELDYYAVLDQPRGATKEQITLAYRRLAIRLCPHRDKKDEQDFVPLAQEGRLTHLSPMGEPRQWAY 69
            |..||.||.....||:|::..|||:||::..|.::..:.:.|..::|
Human     4 ETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQ------------------ 50

  Fly    70 VNMAFDVLGNDLYRAIYDRFGEAGLFEGVMLPNGYFPPYQYDGDHMKVYERVFGSYSPY------ 128
               |::||.:...|.:||:.||..:.||.  ..|.|      |..|.:::..||.....
Human    51 ---AYEVLSDAKKRELYDKGGEQAIKEGG--AGGGF------GSPMDIFDMFFGGGGRMQRERRG 104

  Fly   129 ANVIDAIS-NPPSLY--ATRQHGI----------GVRSKDASTE------------RIIELS--- 165
            .||:..:| ....||  |||:..:          |...|..:.|            ||.::.
Human   105 KNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGM 169

  Fly   166 LEEVRTGCVKLMNVWRQEIVDAKE-------SRLEKRKHTLKLNIAPGTTAGTRFCFKEEGDRYP 223
            ::::::.|::...  ..|.:..|:       .::.:.|..|:::|..|...|.:..|..|||:.|
Human   170 VQQIQSVCMECQG--HGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEP 232

  Fly   224 ATIPGDIIFIAADKPHPDFERRNQHDLVYRQSIGLCQAFTGFTFFICTLDRRQLKVVIT----DV 284
            ...|||||.:...|.|..|.||.: ||.....|.|.:|..||...|.|||.|  .:|||    .:
Human   233 GLEPGDIIIVLDQKDHAVFTRRGE-DLFMCMDIQLVEALCGFQKPISTLDNR--TIVITSHPGQI 294

  Fly   285 VQPGYTKVVPLEGLPKCRNLDAVTAIKEANKKVEQFGDLIIEFDYIFPK--YLTPHMKHITREFF 347
            |:.|..|.|..||:|..|             :..:.|.|||||...||:  :|:|....:..:..
Human   295 VKHGDIKCVLNEGMPIYR-------------RPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLL 346

  Fly   348 REFRKLEIELEEEEERNMV 366
            .| ||   |:||.:|.:.|
Human   347 PE-RK---EVEETDEMDQV 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12020	NP_647662.1	DnaJ	7..352	CDD:223560	101/391 (26%)
		DnaJ	7..87	CDD:278647	19/79 (24%)
		DnaJ_C	156..335	CDD:199909	57/206 (28%)
DNAJA1	NP_001530.1	PTZ00037	2..394	CDD:240236	109/409 (27%)
		CXXCXGXG motif	134..141		1/6 (17%)
		CXXCXGXG motif	150..157		0/6 (0%)
		CXXCXGXG motif	177..184		1/8 (13%)
		CXXCXGXG motif	193..200		0/6 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..397		4/10 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53515
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.880