DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12020 and DNAJA2

DIOPT Version :9

Sequence 1:	NP_647662.1	Gene:	CG12020 / 38233	FlyBaseID:	FBgn0035273	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_005871.1	Gene:	DNAJA2 / 10294	HGNCID:	14884	Length:	412	Species:	Homo sapiens

Alignment Length:	388	Identity:	97/388 - (25%)
Similarity:	155/388 - (39%)	Gaps:	97/388 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NRPELDYYAVLDQPRGATKEQITLAYRRLAIRLCPHRDKKDEQDFVPLAQEGRLTHLSPMGEPRQ 66
            |..:...|.:|..|.||::.::..|||:||...  |.||.      |.|.:             :
Human     3 NVADTKLYDILGVPPGASENELKKAYRKLAKEY--HPDKN------PNAGD-------------K 46

  Fly    67 WAYVNMAFDVLGNDLYRAIYDRFGEAGLFEGVMLPNGYFPPYQYDGDHMKVYERVFGS------- 124
            :..::.|::||.|...|.:|||:||.||.||   ..|       .|....::..:||.
Human    47 FKEISFAYEVLSNPEKRELYDRYGEQGLREG---SGG-------GGGMDDIFSHIFGGGLFGFMG 101

  Fly   125 --------------------------YSPYANVIDAISNPPSLYATRQHGI--GVRSKDASTERI 161
                                      |:.....:....|......:.|.|.  .|:...|...|.
Human   102 NQSRSRNGRRRGEDMMHPLKVSLEDLYNGKTTKLQLSKNVLCSACSGQGGKSGAVQKCSACRGRG 166

  Fly   162 IELSLEEVRTGCVKLMNV------WRQEIVDAKE-------SRLEKRKHTLKLNIAPGTTAGTRF 213
            :.:.:.::..|.|:.|..      ...|:::.|:       .::.|....|::::..|...|.|.
Human   167 VRIMIRQLAPGMVQQMQSVCSDCNGEGEVINEKDRCKKCEGKKVIKEVKILEVHVDKGMKHGQRI 231

  Fly   214 CFKEEGDRYPATIPGDIIFIAADKPHPDFERRNQHDLVYRQSIGLCQAFTGFTFFICTLDRRQLK 278
            .|..|.|:.|...||||:.:..:|.|..|: |:.:||.....|||.:|..||.|....||.||:.
Human   232 TFTGEADQAPGVEPGDIVLLLQEKEHEVFQ-RDGNDLHMTYKIGLVEALCGFQFTFKHLDGRQIV 295

  Fly   279 VVIT--DVVQPGYTKVVPLEGLPKCRNLDAVTAIKEANKKVEQFGDLIIEFDYIFPK--YLTP 337
            |...  .|::||..:||..||:|:.||            ..|: |||.|:||..||:  ::.|
Human   296 VKYPPGKVIEPGCVRVVRGEGMPQYRN------------PFEK-GDLYIKFDVQFPENNWINP 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12020	NP_647662.1	DnaJ	7..352	CDD:223560	96/383 (25%)
		DnaJ	7..87	CDD:278647	20/79 (25%)
		DnaJ_C	156..335	CDD:199909	57/195 (29%)
DNAJA2	NP_005871.1	PTZ00037	4..412	CDD:240236	96/387 (25%)
		CXXCXGXG motif	143..150		0/6 (0%)
		CXXCXGXG motif	159..166		1/6 (17%)
		CXXCXGXG motif	186..193		0/6 (0%)
		CXXCXGXG motif	202..209		0/6 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53515
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.880