DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc37 and CDC37L1

DIOPT Version :9

Sequence 1:	NP_477006.1	Gene:	Cdc37 / 38232	FlyBaseID:	FBgn0011573	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_060383.2	Gene:	CDC37L1 / 55664	HGNCID:	17179	Length:	337	Species:	Homo sapiens

Alignment Length:	271	Identity:	83/271 - (30%)
Similarity:	140/271 - (51%)	Gaps:	37/271 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RWRHQARVERMAEMD-HEKDELKKKRQSYQARLMDVKERISKKDGDEEALKKELEKIEAEGKELD 93
            :|......:::..:. |..:.|.::....|..:.::::|      :||..:||    ||
Human    68 KWNLAEAQQKLGSLALHNSESLDQEHAKAQTAVSELRQR------EEEWRQKE----EA------ 116

  Fly    94 RIESEMIKKEKKTPWNVDTISKPGFEKTVINKKAGRKPDENLSEEEREQRMKQFVKENEKLCQQY 158
                 ::::||...|:.|.|||..|.|:.||:       :...:.|.|.:.:.|:::.|:..:.:
Human   117 -----LVQREKMCLWSTDAISKDVFNKSFINQ-------DKRKDTEDEDKSESFMQKYEQKIRHF 169

  Fly   159 GMLRKYDDSKRFLQEHLHLVGEETANYLVIWSINLEMEEKHELMAHVAHQCICMQYILELAKQLD 223
            |||.::|||:|||.:|.:||.||||.||::|..:||.|:|..||..:|||.:.||:|:|:||..:
Human   170 GMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCN 234

  Fly   224 VDPRACVSSFFSKIQHCHPEYRAQFDSEIEGFKGRIQKRAQ-EKIQEAIAQAEEEERKERLGPGG 287
            ||||.|...||.|.:.....|...|.:|:|.||.|::..:| :..|....|       ..:...|
Human   235 VDPRGCFRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQ-------NHVPHSG 292

  Fly   288 LDPADVFESLP 298
            :....:.||||
Human   293 VGSIGLLESLP 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc37	NP_477006.1	CDC37_N	1..121	CDD:198139	19/91 (21%)
		CDC37_M	130..266	CDD:215010	54/136 (40%)
		CDC37_C	283..372	CDD:215009	5/16 (31%)
CDC37L1	NP_060383.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		Self-association	2..171		26/130 (20%)
		CDC37_N	<71..139	CDD:296150	18/88 (20%)
		CDC37_M	138..282	CDD:215010	58/150 (39%)
		Self-association and interaction with Hsp90	147..277		54/129 (42%)
		Interaction with Hsp70	267..337		10/44 (23%)
		Required for interaction with STIP1	278..337		7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159336
Domainoid	1	1.000	128	1.000	Domainoid score	I5319
eggNOG	1	0.900	-	-		E1_KOG2260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D451416at33208
OrthoFinder	1	1.000	-	-		FOG0002158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12800
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.810