DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc37 and cdc37

DIOPT Version :9

Sequence 1:	NP_477006.1	Gene:	Cdc37 / 38232	FlyBaseID:	FBgn0011573	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_595752.1	Gene:	cdc37 / 2541293	PomBaseID:	SPBC9B6.10	Length:	466	Species:	Schizosaccharomyces pombe

Alignment Length:	463	Identity:	116/463 - (25%)
Similarity:	182/463 - (39%)	Gaps:	146/463 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VDYSKWKNIEISDDED-DTHPNIDTPSLFRWR----HQAR--------------------VERMA 41
            :|||||..:|:|||.| :.|||:|..|..|||    |:.|                    :.|::
pombe     3 IDYSKWDKLELSDDSDIEVHPNVDKKSFIRWRQRDIHEKRAVRKQKMEDIKGAMAMNRRLLSRIS 67

  Fly    42 EMDH--EKD-------------ELKKKR---------QSYQARLM----------DVKERISKKD 72
            ||:.  ||:             |.||..         .||...||          |..|..|..|
pombe    68 EMETVLEKESPSDPYVLLGSFLEAKKSEDMDSAIPGGMSYHHMLMSLLKVIKDAEDTTEEKSMDD 132

  Fly    73 GDE----------------EALKKELEKIEAEGKELDRIESEMI----------KKE----KKTP 107
            .|:                |..:||.:.:|||.|  :.|.||.:          |||    |||.
pombe   133 SDKCLRRLKSHKERLLKLLEDAQKEYDTLEAESK--NYITSEDLHLGFDSTYVQKKEPEKPKKTK 195

  Fly   108 WNVDTISK-------------PGFEKTVINKKAGRKP-DENLSEEEREQRMKQFVKENEKLCQQY 158
            ...:||..             ||.::......|.:.| :||.||:|....:.:..|:...:  .:
pombe   196 TKKETIQVIESLNNPTPPTDFPGAKEQASTGNAPKNPVNENESEDEEGLSLSEDGKKFANI--DF 258

  Fly   159 GMLRKYDDSKRFLQEHLH-LVGEETANYLVIWSINLEMEEKHELMAHVAHQCICMQYILELAKQL 222
            |   .|..|:.||:|||: |..||.::.:::.:.|.|:|.|..|.....||.:.:.|..:|.
pombe   259 G---DYSSSEEFLKEHLNILADEEESDAILLEAFNAELEGKPSLAKQYVHQALLISYCRQLG--- 317

  Fly   223 DVDPRACVSSFFSKIQHCHPEYRAQ--FDSEIEGFKGRIQKRAQEKIQEAIAQAEEEERKERL-- 283
               |.. :|.||.||:  .|.:::|  |..::.....||.:|:....:|   |||..|..|::
pombe   318 ---PNG-LSIFFQKIK--DPNHQSQRLFLEDVHNTYVRIHERSAAISKE---QAESGEGVEQIQL 373

  Fly   284 --------------GPGGLDPAD-----VFESLPDELKACFESRDVELLQKTIAAMPVDVAKLHM 329
                          ..|..||..     .|||.|..|:....:.|::.:...:..|.|:.|:..:
pombe   374 CAVDPNTKLSITIPEAGSTDPETQKARAAFESFPPNLQKALMTNDLDKINVVLGKMAVENAEEVV 438

  Fly   330 KRCVDSGL 337
            ::...:|:
pombe   439 EKLSSTGM 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc37	NP_477006.1	CDC37_N	1..121	CDD:198139	57/220 (26%)
		CDC37_M	130..266	CDD:215010	39/139 (28%)
		CDC37_C	283..372	CDD:215009	13/76 (17%)
cdc37	NP_595752.1	CDC37_N	2..181	CDD:198139	47/179 (26%)
		CDC37_M	252..363	CDD:285734	34/127 (27%)
		CDC37_C	386..453	CDD:285733	13/61 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	52	1.000	Domainoid score	I3331
eggNOG	1	0.900	-	-		E1_KOG2260
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	80	1.000	Inparanoid score	I1853
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12800
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R180
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.990