DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc37 and Cdc37

DIOPT Version :9

Sequence 1:	NP_477006.1	Gene:	Cdc37 / 38232	FlyBaseID:	FBgn0011573	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_001365725.1	Gene:	Cdc37 / 12539	MGIID:	109531	Length:	428	Species:	Mus musculus

Alignment Length:	437	Identity:	196/437 - (44%)
Similarity:	267/437 - (61%)	Gaps:	73/437 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVDYSKWKNIEISDDEDDTHPNIDTPSLFRWRHQARVERMAEMDHEKDEL-------KKKRQSYQ 58
            |||||.|.:||:|||||:|||||||.||||||||||||||.:...||:||       |:|....|
Mouse     1 MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQ 65

  Fly    59 ARLMDVKERISKKDGDEEALKKELEKIEAEGKELDRIE-------SEMIKKEKKTPWNVDTISKP 116
            .:|.:::  :::.||     :.|||::.||.::|.:.|       .:|.||||..||||||:||.
Mouse    66 RKLKELE--VAESDG-----QVELERLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTLSKD 123

  Fly   117 GFEK---------------------------------------------TVINKKAGRKPD--EN 134
            ||.|                                             |:.......||:  |.
Mouse   124 GFSKARGHASATLMHLATPPPPMWTGWARRPRPPNPRRTPALPQPTCPLTLSQSMVNTKPEKAEE 188

  Fly   135 LSEEEREQRMKQFVKENEKLCQQYGMLRKYDDSKRFLQEHLHLVGEETANYLVIWSINLEMEEKH 199
            .|||.|||:.|.||::.||..:.:|||.::|||:::|.:::|||.||||||||||.|:||:|||.
Mouse   189 DSEEAREQKHKTFVEKYEKQIKHFGMLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKC 253

  Fly   200 ELMAHVAHQCICMQYILELAKQLDVDPRACVSSFFSKIQHCHPEYRAQFDSEIEGFKGRIQKRAQ 264
            .||..||||.:.||:||||||.|.||||||...||:||:....:|...|..|:|.||.|::.||:
Mouse   254 ALMEQVAHQTMVMQFILELAKSLKVDPRACFRQFFTKIKTADHQYMEGFKYELEAFKERVRGRAK 318

  Fly   265 EKIQEAIAQAEEEERKERLGPGGLDPADVFESLPDELKACFESRDVELLQKTIAAMPVDVAKLHM 329
            .:|::|:.:.||||||:|||||||||.:|:||||:||:.||:.:||::||..|:.|....||.||
Mouse   319 LRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHM 383

  Fly   330 KRCVDSGLWVPNAADLEGDKKEEDDS---DDVAGGEEKTDDAKSESA 373
            :||:||||||||:.  .|:.||.:::   |.:.....|..:.|..||
Mouse   384 QRCIDSGLWVPNSK--SGEAKEGEEAGPGDPLLEAVPKAGNEKDVSA 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc37	NP_477006.1	CDC37_N	1..121	CDD:198139	67/178 (38%)
		CDC37_M	130..266	CDD:215010	74/137 (54%)
		CDC37_C	283..372	CDD:215009	43/91 (47%)
Cdc37	NP_001365725.1	CDC37_N	1..127	CDD:198139	68/184 (37%)
		CDC37_M	183..325	CDD:215010	79/141 (56%)
		CDC37_C	337..427	CDD:215009	13/40 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849703
Domainoid	1	1.000	123	1.000	Domainoid score	I5571
eggNOG	1	0.900	-	-		E1_KOG2260
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38268
Inparanoid	1	1.050	371	1.000	Inparanoid score	I2102
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002158
OrthoInspector	1	1.000	-	-		oto94581
orthoMCL	1	0.900	-	-		OOG6_106448
Panther	1	1.100	-	-	LDO	PTHR12800
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R180
SonicParanoid	1	1.000	-	-		X5657
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790