DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc37 and Cdc37

DIOPT Version :9

Sequence 1:	NP_477006.1	Gene:	Cdc37 / 38232	FlyBaseID:	FBgn0011573	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	XP_038936628.1	Gene:	Cdc37 / 114562	RGDID:	71006	Length:	428	Species:	Rattus norvegicus

Alignment Length:	432	Identity:	191/432 - (44%)
Similarity:	268/432 - (62%)	Gaps:	63/432 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVDYSKWKNIEISDDEDDTHPNIDTPSLFRWRHQARVERMAEMDHEKDELKKKRQSYQARLMDVK 65
            |||||.|.:||:|||||:|||||||.||||||||||||||.:...||:||.:..:..:.::.:.:
  Rat     1 MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQ 65

  Fly    66 ERISKKDGDEEALKKELEKIEAEGKELDRIE-------SEMIKKEKKTPWNVDTISKPGFEK--- 120
            .::.:.:..|...:.|||::.||.::|.:.|       .:|.||||..||||||:||.||.|
  Rat    66 RKLKELEVAEGGGQVELERLRAEAQQLRKEERSWEQKLEDMRKKEKNMPWNVDTLSKDGFSKARG 130

  Fly   121 ----------------------------------------------TVINKKAGRKPDENLSEEE 139
                                                          :::|.|. .|.:|: |||.
  Rat   131 HASATLMHLATPPPPMWTGWARRPRPPNPRRTPALPQPTCPLALSQSMVNTKP-EKAEED-SEEA 193

  Fly   140 REQRMKQFVKENEKLCQQYGMLRKYDDSKRFLQEHLHLVGEETANYLVIWSINLEMEEKHELMAH 204
            |||:.|.||::.||..:.:|||.::|||:::|.:::|||.||||||||||.|:||:|||..||..
  Rat   194 REQKHKTFVEKYEKQIKHFGMLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQ 258

  Fly   205 VAHQCICMQYILELAKQLDVDPRACVSSFFSKIQHCHPEYRAQFDSEIEGFKGRIQKRAQEKIQE 269
            ||||.:.||:||||||.|.||||||...||:||:....:|...|..|:|.||.|::.||:.:|::
  Rat   259 VAHQTMVMQFILELAKSLKVDPRACFRQFFTKIKTADQQYMEGFKYELEAFKERVRGRAKLRIEK 323

  Fly   270 AIAQAEEEERKERLGPGGLDPADVFESLPDELKACFESRDVELLQKTIAAMPVDVAKLHMKRCVD 334
            |:.:.||||||:|||||||||.:|:||||:||:.||:.:||::||..|:.|....||.||:||:|
  Rat   324 AMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCID 388

  Fly   335 SGLWVPNAADLEGDKKEEDDS---DDVAGGEEKTDDAKSESA 373
            |||||||:.  .|:.||.:::   |.:.....|..:.|..||
  Rat   389 SGLWVPNSK--SGEAKEGEEAGPGDPLLEAVPKAGNEKDISA 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc37	NP_477006.1	CDC37_N	1..121	CDD:198139	62/175 (35%)
		CDC37_M	130..266	CDD:215010	73/135 (54%)
		CDC37_C	283..372	CDD:215009	43/91 (47%)
Cdc37	XP_038936628.1	CDC37_N	1..127	CDD:198139	63/181 (35%)
		CDC37_M	183..325	CDD:215010	79/141 (56%)
		CDC37_C	337..427	CDD:215009	13/40 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353361
Domainoid	1	1.000	124	1.000	Domainoid score	I5389
eggNOG	1	0.900	-	-		E1_KOG2260
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38268
Inparanoid	1	1.050	371	1.000	Inparanoid score	I2056
OMA	1	1.010	-	-		QHG59082
OrthoDB	1	1.010	-	-		D451416at33208
OrthoFinder	1	1.000	-	-		FOG0002158
OrthoInspector	1	1.000	-	-		oto98094
orthoMCL	1	0.900	-	-		OOG6_106448
Panther	1	1.100	-	-	LDO	PTHR12800
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5657
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770