DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Spec and Clmn

DIOPT Version :9

Sequence 1:	NP_001261286.1	Gene:	alpha-Spec / 38231	FlyBaseID:	FBgn0250789	Length:	2457	Species:	Drosophila melanogaster
Sequence 2:	NP_444385.2	Gene:	Clmn / 94040	MGIID:	2136957	Length:	1052	Species:	Mus musculus

Alignment Length:	848	Identity:	163/848 - (19%)
Similarity:	292/848 - (34%)	Gaps:	207/848 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 REKLEDSRRFQYFKRDADELE---SWIHEKLQAASEESYRDPTNLQAKIQKHQAFEAEVSAHSNA 101
            ::.||||.|        |.||   |..|:.|..   ....:|.::...:...|:....|:.....
Mouse   236 KQALEDSTR--------DNLEKAFSIAHDSLHI---PRLLEPEDIMVDMPDEQSIVTYVAQFLER 289

  Fly   102 IVSLDNTGQEMINQQHFAS-ESIQVRLDELHKLWE-----LLLSRLAEKGLKLQQALVLVQFLRQ 160
            ...|:  .::.:|....|. ||..||:.|...  |     ||||...|:...:.|
Mouse   290 FPELE--PEDFVNPDKEAPIESTFVRIKESPS--EQGSRVLLLSENGERAYTVNQ---------- 340

  Fly   161 CEEVMFWIKDKETFVTADE------FGQDLEHVEVLQRKFDEFQKDMASQEYRVTEVNQLADKLV 219
              |..:...|| .|| .|:      |..|......|.....||..::..|   |.:.:......:
Mouse   341 --ETSYPPPDK-VFV-CDQLESPTGFCLDSAPSHKLSDSSTEFMHEIIDQ---VLQGSTGKTGSI 398

  Fly   220 QDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNRDADETVAWIAEKDVVLSSD 284
            .:..||...::.||:     .:|...|.:.:.     .|.....::||.      ..||...|||
Mouse   399 AEPTPESSILSTRKD-----GRRSNSLPVKKT-----VHFEADLHKDAS------CSKDPFYSSD 447

  Fly   285 ----------------DYGRDLASVQALQRKHEGVER-DLAALEDKV--STL-GAEA-------- 321
                            |....||.|...::|.|...| .|.|..|||  ||: |.:|
Mouse   448 FRFEGSPKATKELSKQDGHVSLAEVSKEKKKSEQEARLVLEAASDKVPESTVDGLDAVPQDAQPS 512

  Fly   322 --QRLC-----------------SIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYY-- 365
              ...|                 |...||:......:.::    |.||.:..::     |.|:
Mouse   513 QDSSFCNGTVESPSSQGEKGPPPSSPGDHTLLANSTELKV----QLLTVEPMDK-----EDYFEC 568

  Fly   366 ----LHRFLADFRDLVSWINGMKAIISADELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTES 426
                ..:|   .||||.:.:..:|........:...|.|...|.|.|..|:  .:..|.:..||:
Mouse   569 IPLKASKF---NRDLVDFASTSQAFGEDPSSHEKTRGEEEGSENHAEKPGK--RKSKSPRAETEA 628

  Fly   427 GQKLLEREHYAA----AEIQEKLAALENDKSSLLSLWEDRRILYEQCMDLQLFYRDTEQAD---- 483
            .:..||.:....    .|.:::..||..:..:     :.:..:||:.......:...|:.:
Mouse   629 AESRLEPKKLEPPPKDPEQEDQGHALPPETPA-----DKKPKVYEKAKRKSTRHHSEEEGEAESG 688

  Fly   484 -TWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIKALDIFATKLIDGQHY----- 542
             :.:.::|...|......||:::.:..::..||:.|....:..:...|:|..     .||
Mouse   689 FSAVCEEEIPSAPPSTSVSLETLRSHSEEGLDFKPSPPLSKISVIPHDLFYY-----PHYEVPLA 748

  Fly   543 -AADDVAQRRQMLLARRAALQE------KSSKRRQLLEDSNRYQQFERDC------DETKGWISE 594
             ..:..|:..:.|.:....|:.      :.|:..:..||....|..:..|      |.:...:||
Mouse   749 AVLEAYAEGGEDLKSEDTDLEHPEDSYLQDSREEEADEDEEEAQSSQSSCSFSLPVDNSYPSVSE 813

  Fly   595 KLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAADQINTRMQEI 659
            .:.. .|.|...||:..|......:.:|:....|.      |...|..:.|.....::.|:..|
Mouse   814 HVSH-VDGSSEGPTSALGPGSPPSHEDHQPKETKE------NGPVESQQSQEPPNPELPTKPLE- 870

  Fly   660 VVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHA 724
                |.|.:||        .:.::::..:.::.:|..|....|.:.|.|..::.:|...:..::
Mouse   871 ----EKLTEAS--------TSSKKKEKRKHMDHVESSLFIAPGTVRSSDDLEENSSEHKVPSRN- 922

  Fly   725 LLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAPMGERKQHLLDSLQV 789
                   :|.|....|:...|:.:|..||....:||            ||.:.:|:..:|:....
Mouse   923 -------SHSDSSIYIRRHTNRSLELDHFSYVQLRN------------AADLDDRRNRVLNRYNS 968

  Fly   790 QQL 792
            |:|
Mouse   969 QKL 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Spec	NP_001261286.1	SH3_Alpha_Spectrin	974..1026	CDD:212742
		SPEC	1074..1287	CDD:238103
		SPEC	1182..1425	CDD:238103
		SPEC	1426..1638	CDD:238103
		SPEC	1533..1744	CDD:238103
		SPEC	1646..1850	CDD:238103
		SPEC	1852..2062	CDD:238103
		SPEC	1958..2176	CDD:238103
		SPEC	2072..2296	CDD:238103
		EFh	2311..2379	CDD:238008
		EFhand_Ca_insen	2386..2456	CDD:400872
		SPEC	48..258	CDD:238103	44/224 (20%)
		SPEC	154..364	CDD:238103	51/262 (19%)
		SPEC	261..470	CDD:238103	54/265 (20%)
		SPEC	471..680	CDD:238103	39/231 (17%)
		SPEC	682..893	CDD:238103	21/111 (19%)
		Spectrin	893..>961	CDD:395348
Clmn	NP_444385.2	Actin-binding	1..288		14/62 (23%)
		CH	33..134	CDD:278723
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..178
		CH	191..286	CDD:278723	14/60 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..420		5/33 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..545		20/89 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..727		25/148 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..929		34/198 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010