DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Spec and ACTN1

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:XP_016877209.1 Gene:ACTN1 / 87 HGNCID:163 Length:1106 Species:Homo sapiens


Alignment Length:1244 Identity:270/1244 - (21%)
Similarity:449/1244 - (36%) Gaps:469/1244 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  1505 KRKQVLERWRHLKEGLIEKRSRLGDEQTLQQFSRDADEIENWIAEKLQLA------TEESYKDPA 1563
            |||:...:..:.|     |...|| |:||::....::....|....|:.|      .||.::|..
Human    34 KRKEEAYKSENPK-----KLKWLG-EKTLKRPWSTSETFTAWCNSHLRKAGTQIENIEEDFRDGL 92

  Fly  1564 NI----------------QSKHQKHQAFEAE-----LAANADRIQSVLA---MGGNLIDKKQCSG 1604
            .:                :.|.:.|:.....     :|:...::.|:.|   :.||:   |...|
Human    93 KLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV---KMTLG 154

  Fly  1605 S------EDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTT 1663
            .      ..|:|....:.....|.|......|:...|..|.|..:|:       |          
Human   155 MIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHIS-------W---------- 202

  Fly  1664 EDSGKDLASVQNLMKKH--QLVEADIVAHEDRIKDMNN---------------QADSLVESGQFD 1711
                ||......|:.:|  :|::...:..:|.:.::|.               .|:.:|.:.:.|
Human   203 ----KDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPD 263

  Fly  1712 T--------------AGIQEKRQSINERYERICNLAAHRQARLNEALTLHQFFRDIADEESWIK- 1761
            .              :|.|:...:.|    |||.:.|..|.  ||.| :..:.:..:|...||: 
Human   264 EKAIMTYVSSFYHAFSGAQKAETAAN----RICKVLAVNQE--NEQL-MEDYEKLASDLLEWIRR 321

  Fly  1762 -----------------EKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELG----------SHEPA 1799
                             ::||    :|: ||...:....|..::.:.|:.          |:.||
Human   322 TIPWLENRVPENTMHAMQQKL----EDF-RDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPA 381

  Fly  1800 IQAVQEAGEKLMDVSNL-GVPEIEQRLKALNQAWA--ELKNLAATRGQKLDESLTYQQFLAQVEE 1861
            .  :...|..:.|::|. |.  :||..|...: |.  |::.|     ::||.  ..::|..:...
Human   382 F--MPSEGRMVSDINNAWGC--LEQVEKGYEE-WLLNEIRRL-----ERLDH--LAEKFRQKASI 434

  Fly  1862 EEAWITE--------KQQLLSVEDYGD-SMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSELV 1917
            .|||...        |:.:|..:||.. :::.::.|||||:|||:|..||:||...|.....||.
Human   435 HEAWTDAMWPSLNPGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELN 499

  Fly  1918 EAKNHHGESIAQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFMWKADVVESWIDDKENYVRSD 1982
            |...:...|:..|||::..:.|||.||..:|:.||                              
Human   500 ELDYYDSPSVNARCQKICDQWDNLGALTQKRREAL------------------------------ 534

  Fly  1983 EFGRDLSTVQTLLTKQETFDAGLNAFEQEGIHNITALKDQLINASHAQSPAILKRHGDVIARWQK 2047
                                                                             
Human   535 ----------------------------------------------------------------- 534

  Fly  2048 LRDASNTRKDRLLAMQEQFRQIEELYLTFAKKASAFNSWFENAEEDLTDPVRCNSIEEIRALRDA 2112
                  .|.::||      ..|::|||.:||:|:.||:|.|.|.|||.|....::||||:.|..|
Human   535 ------ERTEKLL------ETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTA 587

  Fly  2113 HAQFQASLSSAEADFKALAALDQK----IKSFNV---GPNPYTWFTMEALEETWRNLQKIIEERD 2170
            |.||:|:|..|:.:..|:..:..:    :::::|   |.||||..|.:.:...|.::::::..||
Human   588 HEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRD 652

  Fly  2171 GELAKEAKRQEENDKLRKEFAKHANLFHQWLTETRYYMLGYNRQGTSMMEGSGSLEQQLEALRVK 2235
            ..|.:|..||:.|::|||:|...||:...|: :|:...:     |...:|..|:||.||..||..
Human   653 QALTEEHARQQHNERLRKQFGAQANVIGPWI-QTKMEEI-----GRISIEMHGTLEDQLSHLRQY 711

  Fly  2236 ATEVRARRVDLKKIEELGALLEEHLILDNRYT----EHSTVGLAQQWDQLDQLSMRMQHNLEQQI 2296
            ...:...:..:.::|....|::|.||.||::|    ||..||    |:||.....|..:.:|.||
Human   712 EKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVG----WEQLLTTIARTINEVENQI 772

  Fly  2297 QARNHSGVSEDSLKEFSMMFKHFDKDKSGKLNHQEFKSCLRALGYDL---PMV-----EEGQ--- 2350
            ..|:..|:|::.:.||...|.|||:|.||.|..:|||:||.:||||:   |.|     |..|   
Human   773 LTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQVLASCMEHAQGWR 837

  Fly  2351 ----------------------------------------------------------------- 2350
                                                                             
Human   838 LGQEIMRFSFFSSLCLDLLSPSCGPWGSSSPAVSVCPITGPPSALCCLSWQPTGCPLSSVLAALH 902

  Fly  2351 ------------------------------------------------------PDP-------- 2353
                                                                  |.|        
Human   903 PMGGFLHLPALSSSCLWTFPPMCVRIFSYVPLPILTPKTINLIPVLAICSCLPGPGPALPLPAFP 967

  Fly  2354 -------------------------------------EFEAILDVVDPNRDGYVSLQEYIAFMIS 2381
                                                 ||..|:.:|||||.|.|:.|.:|.|| |
Human   968 TLLVSWYHCPPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFM-S 1031

  Fly  2382 KETENVQSYEEIENAFRAITAADRPYVTKEELYCNLTKDMADYCVQRMKPFSEPRSGQPIKDALD 2446
            :||.:..:.:::..:|: |.|.|:.|:|.:||...|..|.|:||:.||.|::.|.|   :..|||
Human  1032 RETADTDTADQVMASFK-ILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDS---VPGALD 1092

  Fly  2447 YIDFTRTLF 2455
            |:.|:..|:
Human  1093 YMSFSTALY 1101

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742
SPEC 1074..1287 CDD:238103
SPEC 1182..1425 CDD:238103
SPEC 1426..1638 CDD:238103 31/168 (18%)
SPEC 1533..1744 CDD:238103 46/277 (17%)
SPEC 1646..1850 CDD:238103 47/265 (18%)
SPEC 1852..2062 CDD:238103 40/218 (18%)
SPEC 1958..2176 CDD:238103 43/224 (19%)
SPEC 2072..2296 CDD:238103 77/234 (33%)
EFh 2311..2379 CDD:238008 37/242 (15%)
EFhand_Ca_insen 2386..2456 CDD:400872 24/70 (34%)
SPEC 48..258 CDD:238103
SPEC 154..364 CDD:238103
SPEC 261..470 CDD:238103
SPEC 471..680 CDD:238103
SPEC 682..893 CDD:238103
Spectrin 893..>961 CDD:395348
ACTN1XP_016877209.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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