DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alpha-Spec and ACTN4

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:XP_016882820.1 Gene:ACTN4 / 81 HGNCID:166 Length:933 Species:Homo sapiens


Alignment Length:1125 Identity:262/1125 - (23%)
Similarity:455/1125 - (40%) Gaps:331/1125 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1449 NADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQTVADQLIAQNHYASNLVD----EKRKQV 1509
            :|.:.|..||::...:.:.:|:|:.:                          |:|    :::::.
Human    17 SAGNGAGGGGSMGDYMAQEDDWDRDL--------------------------LLDPAWEKQQRKT 55

  Fly  1510 LERW--RHLKEGLIEKRSRLGDEQTLQQFSRDADEIENWIAE------KLQLATE--ESYKDPAN 1564
            ...|  .||::.                    ..:||| |.|      ||.|..|  ...:.|..
Human    56 FTAWCNSHLRKA--------------------GTQIEN-IDEDFRDGLKLMLLLEVISGERLPKP 99

  Fly  1565 IQSKHQKHQAFEAELAAN--ADRIQSVLAMGGNLI---DKKQCSGS------EDAVQKRLTQIAD 1618
            .:.|.:.|:......|.:  |.:...::::|...|   :.|...|.      ..|:|....:...
Human   100 ERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETS 164

  Fly  1619 QWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKKH--Q 1681
            ..|.|......|:...|..|.|..:|:       |              ||..:...|:.:|  :
Human   165 AKEGLLLWCQRKTAPYKNVNVQNFHIS-------W--------------KDGLAFNALIHRHRPE 208

  Fly  1682 LVEADIVAHEDRIKDMNN---------------QADSLVESGQFDT--------------AGIQE 1717
            |:|.|.:..:|.:.::||               .|:.:|.:.:.|.              :|.|:
Human   209 LIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQK 273

  Fly  1718 KRQSINERYERICNLAAHRQARLNEALTLHQFFRDIADEESWIK------------------EKK 1764
            ...:.|    |||.:.|..|.  ||.| :..:.:..:|...||:                  ::|
Human   274 AETAAN----RICKVLAVNQE--NEHL-MEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQK 331

  Fly  1765 LLVGSDDYGRDLTGVQNLKKKHKRLEAELG----------SHEPAIQAVQEAGEKLMDVSNLGVP 1819
            |    :|: ||...|....|..::.:.|:.          |:.||.  :...|:.:.|::| |..
Human   332 L----EDF-RDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAF--MPSEGKMVSDINN-GWQ 388

  Fly  1820 EIEQRLKALNQAWA--ELKNLAATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLLSVEDYGD-S 1881
            .:||..|...: |.  |::.|     ::||.  ..::|..:....|||...|:.:|...||.. :
Human   389 HLEQAEKGYEE-WLLNEIRRL-----ERLDH--LAEKFRQKASIHEAWTDGKEAMLKHRDYETAT 445

  Fly  1882 MAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSELVEAKNHHGESIAQRCQQLRLKLDNLSALAA 1946
            ::.::.|::||:|||:|..||:||...|.....||.|...:...::..|||:             
Human   446 LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQK------------- 497

  Fly  1947 RRKGALLDNSAYLQFMWKADVVESWIDDKENYVRSDEFGRDLSTVQTLLTKQETFDAGLNAFEQE 2011
                                                                             
Human   498 ----------------------------------------------------------------- 497

  Fly  2012 GIHNITALKDQLINASHAQSPAILKRHGDVIARWQKLRDASNTRKDRLLAMQEQFRQIEELYLTF 2076
                                         :..:|..|...:::|::.|...::|...|::|:|.:
Human   498 -----------------------------ICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEY 533

  Fly  2077 AKKASAFNSWFENAEEDLTDPVRCNSIEEIRALRDAHAQFQASLSSAEADFKALAALD---QKIK 2138
            ||:|:.||:|.|:|.|||.|....::||||..|..||.||:::|..|:.:.:|:.|:.   |:|.
Human   534 AKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIA 598

  Fly  2139 SFN----VGPNPYTWFTMEALEETWRNLQKIIEERDGELAKEAKRQEENDKLRKEFAKHANLFHQ 2199
            ..|    .|.||||..|.:.:...|..:|:::.:||..|.:|..:|:.|:.||::||..||:...
Human   599 ESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGP 663

  Fly  2200 WLTETRYYMLGYNRQGTSMMEGSGSLEQQLEALRVKATEVRARRVDLKKIEELGALLEEHLILDN 2264
            |: :|:...:     |...:|.:|:||.||..|:.....:...:.:|..:|:...|::|.||.||
Human   664 WI-QTKMEEI-----GRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDN 722

  Fly  2265 RYT----EHSTVGLAQQWDQLDQLSMRMQHNLEQQIQARNHSGVSEDSLKEFSMMFKHFDKDKSG 2325
            ::|    ||..||    |:||.....|..:.:|.||..|:..|:|::.::||...|.|||||..|
Human   723 KHTNYTMEHIRVG----WEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGG 783

  Fly  2326 KLNHQEFKSCLRALGYDLPMVEEGQP--------------------DPEFEAILDVVDPNRDGYV 2370
            .|..:|||:||.:||||:....:.|.                    :.||..|:.:||||..|.|
Human   784 ALGPEEFKACLISLGYDVENDRQKQTGSMDSDDFRALLISTGYSLGEAEFNRIMSLVDPNHSGLV 848

  Fly  2371 SLQEYIAFMISKETENVQSYEEIENAFRAITAADRPYVTKEELYCNLTKDMADYCVQRMKPFSEP 2435
            :.|.:|.|| |:||.:..:.:::..:|: :.|.|:.::|.|||...|..|.|:||:.||.|:..|
Human   849 TFQAFIDFM-SRETTDTDTADQVIASFK-VLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGP 911

  Fly  2436 RSGQPIKDALDYIDFTRTLF 2455
               ..:..||||..|:..|:
Human   912 ---DAVPGALDYKSFSTALY 928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742
SPEC 1074..1287 CDD:238103
SPEC 1182..1425 CDD:238103
SPEC 1426..1638 CDD:238103 35/213 (16%)
SPEC 1533..1744 CDD:238103 51/260 (20%)
SPEC 1646..1850 CDD:238103 51/264 (19%)
SPEC 1852..2062 CDD:238103 30/210 (14%)
SPEC 1958..2176 CDD:238103 47/224 (21%)
SPEC 2072..2296 CDD:238103 78/234 (33%)
EFh 2311..2379 CDD:238008 31/87 (36%)
EFhand_Ca_insen 2386..2456 CDD:400872 22/70 (31%)
SPEC 48..258 CDD:238103
SPEC 154..364 CDD:238103
SPEC 261..470 CDD:238103
SPEC 471..680 CDD:238103
SPEC 682..893 CDD:238103
Spectrin 893..>961 CDD:395348
ACTN4XP_016882820.1 CH_ACTN_rpt1 47..151 CDD:409063 21/124 (17%)
CH_ACTN_rpt2 155..269 CDD:409065 22/134 (16%)
SPEC 296..517 CDD:238103 55/343 (16%)
SPEC 414..640 CDD:238103 73/332 (22%)
SPEC 532..754 CDD:238103 76/231 (33%)
PTZ00184 759..>890 CDD:185504 44/132 (33%)
EFhand_Ca_insen 863..929 CDD:400872 22/70 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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