DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Spec and Sptbn4

DIOPT Version :9

Sequence 1:	NP_001261286.1	Gene:	alpha-Spec / 38231	FlyBaseID:	FBgn0250789	Length:	2457	Species:	Drosophila melanogaster
Sequence 2:	XP_006540500.1	Gene:	Sptbn4 / 80297	MGIID:	1890574	Length:	2580	Species:	Mus musculus

Alignment Length:	1876	Identity:	460/1876 - (24%)
Similarity:	781/1876 - (41%)	Gaps:	341/1876 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHE--KLQAASEESYRDPTN 80
            :.||......|:...:....::..:|:::|....|..|.|.|..|:.:  :|.||.:..: |..:
Mouse   759 LAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGH-DEAS 822

  Fly    81 LQAKIQKHQAFEAEVSAHSNAIVSL----------DNTGQEMINQQHFASESIQVRLDELHKLWE 135
            .:...::|:|...||.||...:..|          ...|..::        ::|||:.|..:|:.
Mouse   823 SRRLARQHRALTGEVEAHRGPVGGLRRQLATLGGASGAGPLVV--------ALQVRVVEAEQLFA 879

  Fly   136 LLLSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQKD 200
            .:....|.:...|:.||.:.:...:......||.:||.::.|......|:.|||:|.:|:...::
Mouse   880 EVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLAMRVPDSLDDVEVVQHRFESLDQE 944

  Fly   201 MASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNR 265
            |.|...||.:|||...:||:.|||..|.:...::.||..|.|:.:|...|:|::.....::....
Mouse   945 MNSLMGRVLDVNQTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVL 1009

  Fly   266 DADETVAWIAEK-DVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLCSIHA 329
            :..|..|.:.|| ..|.|:...|      .|||.:..|:|..|.|||.:.:.|..||..|.....
Mouse  1010 EVAEVRAQVREKRRAVESAPRAG------GALQWRLSGLEAALQALEPRQAALLEEAALLAERFP 1068

  Fly   330 DHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELAK 394
            ..:.::.....|:...|.:|...|:...:.:..:..|.|||.|....:.|      ::.|.|.|.
Mouse  1069 AQATRLHQGAEELGAEWGALAGAAQACGEAVAAAGRLQRFLRDLDTFLDW------LVRAQEAAG 1127

  Fly   395 DVAG--------AEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREHYAAAE------IQEKL 445
            .|.|        |:.||.||...|.|:|.||:.:.....:.:.||..|   .||      :.|.|
Mouse  1128 AVEGPLPRSLEEADGLLARHAALKEEVDQREEDYARIVAASEALLASE---GAELGPGLALDEWL 1189

  Fly   446 AALENDKSSLLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIK 510
            ..||.....||.|||:||....|....|||.||..||...:..||..|:..:|..:::|||..:|
Mouse  1190 PHLEVGWHKLLGLWEERREALVQAHVYQLFLRDLCQALAVLRNQEVALSGAELPCTVESVEEAMK 1254

  Fly   511 KHEDFEKSLAAQEEKIK-ALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRR----- 569
            :|.||..::...::|:: |:....:.|..|..|     .::.|..:||   |.|||.:.:
Mouse  1255 RHRDFLTTMELNQQKMQVAVQAAESLLRQGNAY-----GEQAQEAVAR---LLEKSQENQLRAQQ 1311

  Fly   570 --QLLEDSNRYQQFERDCDETKGWISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIE 632
              |.|.|....|.|.|||.|..|||.||:..|.|.:..|...|:.:..:||.|..||..||..:|
Mouse  1312 WMQKLLDQLVLQHFLRDCHELDGWIHEKMLMARDGTREDSHKLHKRWLRHQAFMAELAQNKEWLE 1376

  Fly   633 DITNVGTELIEKQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWL 697
            .|...|.:|::::...|..:..::.||...|..|...:..|..:|.||.:..|..::..:::..|
Mouse  1377 KIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKRL 1441

  Fly   698 SEIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKE 762
            ..:|.||...|.|.||.:|.:..||...:|:.|......:..:: |....:.......:.:..::
Mouse  1442 LHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWCREVGELQ-AQTAALPLEQASKELVGERQ 1505

  Fly   763 GNLSARYAALAAPMGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIK 827
            ..:..|...|..|:.||::.||.|.::.|:..||:||.||::|:.|:|..|.||..|..||..||
Mouse  1506 SAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGTGLQAVQQHIK 1570

  Fly   828 KHQAVLAEINNHEARLLNVISSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDS 892
            |:|.:..||..|..||..|:.....:...:...::.:|:..|.||..|..|:|.:.:|:|.||.:
Mouse  1571 KNQGLRREIQAHGPRLEEVLERAGVLASLRSPEAEAVRRGQEQLQSAWTGLREAAERRQQTLDAA 1635

  Fly   893 LQAHQYFADANEAESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAK 957
            .|..||:.|..|.|:|:.|:|.:....|.||||.|:..|||||..|...:|.:..:|..|..|
Mouse  1636 FQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQ-- 1698

  Fly   958 NCRQQETPVVDITGKECVVALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAA 1022
             ||                                     .||...:.|
Mouse  1699 -CR-------------------------------------ALLEMGHPD---------------- 1709

  Fly  1023 YIKKIDAGLSASQQNLVDNHSIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQ 1087
                       |:|       |::||:|::..|..|..|..||:..|.:....|.|.|:..:|..
Mouse  1710 -----------SEQ-------ISRRQSQVDRLYVALKELGEERRVSLEQQYWLYQLSRQVDELEH 1756

  Fly  1088 WIRDKENHAQIADVVGEDLEEVEVLQKKFDDFNDDL-KANEVRLANMNEIAVQLTSLGQTEAALK 1151
            ||.:||..|...: :|:|.|.|.|||:||.:|..:. .|...|||.:|::..:|...|.|.||..
Mouse  1757 WIAEKEVVAGSPE-LGQDFEHVSVLQEKFSEFASETGTAGRERLAAVNQMVDELIECGHTAAATM 1820

  Fly  1152 IQTQMQDLNEKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLR-S 1215
            .:.: ..|||.|..|..|...:|..|.::.|:.:|..|..|.:..|.||...|.......:.| |
Mouse  1821 AEWK-DGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTAPPEPRPS 1884

  Fly  1216 VQTLQRKHEGVERDLAALRDKIRQLDETANRLMQSHP-DTAEQTYAKQKEINEMWDQIITKSTAR 1279
            ..::||.....|.||..|..::|||.|.|.:|...:. :.||...::::|:.:.|.:::......
Mouse  1885 ASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLAACEDA 1949

  Fly  1280 KEKLLDSYDLQRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISS 1344
            :..:..:.|..||.|..||||:|::.:...:.:.:...||:..|.|:..||          |:
Mouse  1950 RLHVSSTADALRFHSQARDLLSWMDGIAGQIGAADKPRDVSSVEVLMNYHQ----------GL-- 2002

  Fly  1345 APGAAASTSSIASPSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKARED 1409
                                :||::||.......::.|..||......:.||:.:::.|...:|:
Mouse  2003 --------------------KTELEARVPELATCQELGRSLLLNKSAMADEIQAQLDKLGSRKEE 2047

  Fly  1410 LEKAWTERRLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKAI 1474
            :.:.|......|:|.|::..:.::..:|::|::|:|..|.:.:..::...||.||::||.|.||.
Mouse  2048 VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAA 2112

  Fly  1475 NGHEQKIAALQTVADQLIAQNHYASNLVDEKRKQVLERWRHLKEGLIEKRSRLGDEQTLQQFSRD 1539
            ...|::.::|:.:.                               .|||
Mouse  2113 AAWEERFSSLRRLT-------------------------------TIEK---------------- 2130

  Fly  1540 ADEIENWIAEKLQLATEESYKDPANIQSKHQKHQAFEAELAANADRIQSVLAMGGNLIDK----- 1599
                         |..|:|.:.|..:..:  |......||||.|   ..:|..||  .|:
Mouse  2131 -------------LKAEQSKQPPTPLLGR--KFFGDPTELAAKA---APLLRPGG--YDRGLEPL 2175

  Fly  1600 -KQCSGSEDA-VQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFWLGEVE---- 1658
             ::.|.:..| |:.|:..:  :.|....:...:..:|.|.:                |:||
Mouse  2176 ARRASDTLSAEVRTRVGYV--RQELKPERLQPRIDRLPETS----------------GKVEPAAP 2222

  Fly  1659 ---SLLTTEDSGKDLASVQNLMKKHQLVEADIVAHEDRIKDMNNQADSLVESGQFDTAGIQEKRQ 1720
               :|.||:..|...|:             ::|......:::.::|:.|....:      .|:::
Mouse  2223 TAAALDTTDTPGTPAAT-------------ELVRPRSERQELADRAEELPRRRR------SERQE 2268

  Fly  1721 SINERYERICNLAAHRQARLNEALTLHQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKK 1785
            |:::..|    .|..|:....|:          ||.|.            .:...|...:.::::
Mouse  2269 SVDQPEE----TARRRRPERQES----------ADHEG------------PHSLTLGRYEQMERR 2307

  Fly  1786 HKRLEAELGSHEPAIQAVQEAGEKLMDVSNL------------------GVPEIEQ 1823
            .:|.|..:...|.:.|.....||.:...:.|                  |||.:.|
Mouse  2308 RERRERRIERQESSEQETPTRGELVKGKATLADIVEQLQEKEAGPGIPAGVPSLPQ 2363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Spec	NP_001261286.1	SH3_Alpha_Spectrin	974..1026	CDD:212742	3/51 (6%)
		SPEC	1074..1287	CDD:238103	63/215 (29%)
		SPEC	1182..1425	CDD:238103	56/244 (23%)
		SPEC	1426..1638	CDD:238103	40/218 (18%)
		SPEC	1533..1744	CDD:238103	38/224 (17%)
		SPEC	1646..1850	CDD:238103	32/203 (16%)
		SPEC	1852..2062	CDD:238103
		SPEC	1958..2176	CDD:238103
		SPEC	2072..2296	CDD:238103
		EFh	2311..2379	CDD:238008
		EFhand_Ca_insen	2386..2456	CDD:400872
		SPEC	48..258	CDD:238103	57/221 (26%)
		SPEC	154..364	CDD:238103	55/210 (26%)
		SPEC	261..470	CDD:238103	62/223 (28%)
		SPEC	471..680	CDD:238103	66/216 (31%)
		SPEC	682..893	CDD:238103	60/210 (29%)
		Spectrin	893..>961	CDD:395348	26/67 (39%)
Sptbn4	XP_006540500.1	SAC6	75..>423	CDD:227401
		SPEC	450..664	CDD:238103
		SPEC	790..1002	CDD:238103	57/220 (26%)
		SPEC	1106..1210	CDD:197544	36/112 (32%)
		SPEC	1216..1424	CDD:238103	66/215 (31%)
		SPEC	1322..1529	CDD:238103	57/207 (28%)
		SPEC	1531..1742	CDD:238103	79/284 (28%)
		SPEC	1637..1849	CDD:238103	79/287 (28%)
		Spectrin	1849..1948	CDD:334073	26/98 (27%)
		SPEC	1958..>2125	CDD:238103	47/198 (24%)
		PH_beta_spectrin	2437..2541	CDD:269975
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15759at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100348
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820