DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Spec and CLMN

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:XP_011535460.1 Gene:CLMN / 79789 HGNCID:19972 Length:1033 Species:Homo sapiens


Alignment Length:1182 Identity:210/1182 - (17%)
Similarity:386/1182 - (32%) Gaps:392/1182 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   787 LQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGV------QNLIKKHQAVLAEINNHEARLLN 845
            |:|:.||.|::|                 |:.|:.:      :||:.::::     ::|....||
Human    53 LEVKDLFVDIQD-----------------GKILMALLEVLSGRNLLHEYKS-----SSHRIFRLN 95

  Fly   846 VISSGENMLKDQ--PFASDDIRQRLE-----ALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADAN 903
            .|:.....|:|.  ...|.|..:..:     .|...||.:                   .|....
Human    96 NIAKALKFLEDSNVKLVSIDAAEIADGNPSLVLGLIWNII-------------------LFFQIK 141

  Fly   904 EAESWMREKEP---IATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETP 965
            |....:....|   ::.||. |.|.|||                |..|..|.:..|.:.:.|   
Human   142 ELTGNLSRNSPSSSLSPGSG-GTDSDSS----------------FPPTPTAERSVAISVKDQ--- 186

  Fly   966 VVDITGKECVVALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVND-----RQGFVPAAYIK 1025
                  ::.:.||..:.::..|:                   :.|.|.|     |.|....|.||
Human   187 ------RKAIKALLAWVQRKTRK-------------------YGVAVQDFAGSWRSGLAFLAVIK 226

  Fly  1026 KIDAGLSASQQNLVDNHSIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIR 1090
            .||..|...:|.|.            ||..:||              .||:.:.::|..:.:.:.
Human   227 AIDPSLVDMKQALE------------NSTRENL--------------EKAFSIAQDALHIPRLLE 265

  Fly  1091 ------DKENHAQIADVVGEDLEEVEVLQKKFDDFNDDLKANEVRLANMNEIAVQLTSLGQTEAA 1149
                  |..:...|...|.:.||....|:.: |.|:.|           .|:.::.|.:...|..
Human   266 PEDIMVDTPDEQSIMTYVAQFLERFPELEAE-DIFDSD-----------KEVPIESTFVRIKETP 318

  Fly  1150 LKIQTQMQDLNEKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLR 1214
            .:.::::..|.|......|:..|      ::|.        ..:|.::.:|..::      |:.|
Human   319 SEQESKVFVLTENGERTYTVNHE------TSHP--------PPSKVFVCDKPESM------KEFR 363

  Fly  1215 SVQTLQRKHEGVERDLAALRDKIRQ-LDETANRLMQSHPDTAEQTYAKQKEINEMWDQIITKSTA 1278
            .        :||...  ||.|...: :.:..::::|..|       .|..:|:|...:....|:.
Human   364 L--------DGVSSH--ALSDSSTEFMHQIIDQVLQGGP-------GKTSDISEPSPESSILSSR 411

  Fly  1279 RKEKLLDSYDLQR---FLSD-YRDLLAWINSMMSL-------VTSDELAND--VTGAEALIERHQ 1330
            ::....:|..:::   |.:| |:|  .:.:..:||       |..:.|..|  |...|...|:.|
Human   412 KENGRSNSLPIKKTVHFEADTYKD--PFCSKNLSLCFEGSPRVAKESLRQDGHVLAVEVAEEKEQ 474

  Fly  1331 ARRA-------------EIGFTLGI------SSAPGAAAST------SSIASPSGDE---EHRTE 1367
            .:.:             :|....|.      ||..||..||      |...||.|:.   ....:
Human   475 KQESSKIPESSSDKVAGDIFLVEGTNNNSQSSSCNGALESTARHDEESHSLSPPGENTVMADSFQ 539

  Fly  1368 IDARAGTFGAFEQ-------------FGNELL------QA-NHYASPEIKEKIEDLAKAREDLEK 1412
            |.....|..|.|:             |.::|:      || |...||...:..|| |:|.|:..:
Human   540 IKVNLMTVEALEEGDYFEAIPLKASKFNSDLIDFASTSQAFNKVPSPHETKPDED-AEAFENHAE 603

  Fly  1413 AWTERRLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKAINGH 1477
            ...:|.::....      .:|....:..|...|...::.::|....:.    .:....||....|
Human   604 KLGKRSIKSAHK------KKDSPEPQVKMDKHEPHQDSGEEAEGCPSA----PEETPVDKKPEVH 658

  Fly  1478 EQKIAALQTVADQLIAQNHYASNLVDEKRKQVLER---------------WRHLKEGL------- 1520
            |:        |.:...:.||.....|:..:.|.|.               ..|.:|||       
Human   659 EK--------AKRKSTRPHYEEEGEDDDLQGVGEELSSSPPSSCVSLETLGSHSEEGLDFKPSPP 715

  Fly  1521 IEKRSRLGDE------------QTLQQFSRDADEIENWIAEKLQLATEESYKDPANIQSKHQKHQ 1573
            :.|.|.:..:            ..|:.:..|.::::|   |::.|...|.|.  .::.|:.::..
Human   716 LSKVSVIPHDLFYFPHYEVPLAAVLEAYVEDPEDLKN---EEMDLEEPEGYM--PDLDSREEEAD 775

  Fly  1574 AFEA---------ELAANADRIQSVLAMGG----NLIDKKQCSGSEDAVQK-------------- 1611
            ..::         .|.:.:|:: ..|:.||    ...:....:..||..|:              
Human   776 GSQSSSSSSVPGESLPSASDQV-LYLSRGGVGTTPASEPAPLAPHEDHQQRETKENDPMDSHQSQ 839

  Fly  1612 ---RLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASV 1673
               .|..||:.   |....|::|:..|:..|::........|....|.|:|....|:...|.:..
Human   840 ESPNLENIANP---LEENVTKESISSKKKEKRKHVDHVESSLFVAPGSVQSSDDLEEDSSDYSIP 901

  Fly  1674 QNLMKKHQLVEADIVAHEDRIKDMNNQADSLVESGQF------DTAGIQEKRQSINERYERICNL 1732
            ..            .:|.|....:........||..|      :.|.:.::|..|..||.     
Human   902 SR------------TSHSDSSIYLRRHTHRSSESDHFSYVQLRNAADLDDRRNRILTRYS----- 949

  Fly  1733 AAHRQARLNEALTLHQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGSHE 1797
                ..:|.|.:.  ||:...||.:...|..::.:.::..|..::               ||||.
Human   950 ----TQKLTELIL--QFYGIRADMKRESKHARMSMKANSSGEAMS---------------LGSHS 993

  Fly  1798 P----AIQAVQE 1805
            |    ..|.||:
Human   994 PQSDSLTQLVQQ 1005

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 10/56 (18%)
SPEC 1074..1287 CDD:238103 35/219 (16%)
SPEC 1182..1425 CDD:238103 58/304 (19%)
SPEC 1426..1638 CDD:238103 43/275 (16%)
SPEC 1533..1744 CDD:238103 42/246 (17%)
SPEC 1646..1850 CDD:238103 32/170 (19%)
SPEC 1852..2062 CDD:238103
SPEC 1958..2176 CDD:238103
SPEC 2072..2296 CDD:238103
EFh 2311..2379 CDD:238008
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103
SPEC 154..364 CDD:238103
SPEC 261..470 CDD:238103
SPEC 471..680 CDD:238103
SPEC 682..893 CDD:238103 21/118 (18%)
Spectrin 893..>961 CDD:395348 14/70 (20%)
CLMNXP_011535460.1 CH 33..134 CDD:278723 20/102 (20%)
CH 191..286 CDD:278723 26/139 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.010

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