DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Spec and SPTBN1

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_003119.2 Gene:SPTBN1 / 6711 HGNCID:11275 Length:2364 Species:Homo sapiens


Alignment Length:1921 Identity:508/1921 - (26%)
Similarity:871/1921 - (45%) Gaps:358/1921 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ENFTPKEVKILETVEDIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEK 66
            |.:.|.:.::      |::|...:...|.:......::|.:||:|||...|..:..|.|.||.||
Human   599 EGYKPCDPQV------IRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREK 657

  Fly    67 LQAASEESY-RDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDEL 130
            .:..|.:.| :|.|::...:.||:|||.|:|..|.........|::||.::||.||.|:.|:..:
Human   658 EKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYI 722

  Fly   131 HKLWELL--LSRLAEKGLK---------------------------------------------- 147
            .:.|..|  ||.:.:|.|:                                              
Human   723 REQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHK 787

  Fly   148 ---------------------------------------------------------LQQALVLV 155
                                                                     ||..|.|.
Human   788 DVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALY 852

  Fly   156 QFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQKDMASQEYRVTEVNQLADKLVQ 220
            :...:.:....||.:||.::...:..:.||.:||:|.:|:..:.:|.:|..||..|||:|.:|:.
Human   853 KMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMH 917

  Fly   221 DGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNRDADETVAWIAEK-DVVLSSD 284
            .|||....|..::::||..|.:.::|...:::.|..|..||.::.:.:||.:||.|| .|:.|:.
Human   918 SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQ 982

  Fly   285 DYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLCSIHADHSDQIRDKQAEIANYWQSL 349
            |.|.|||.|.|||||..|:||||.|:|.|:|.|..||::|.|.|.|.:..|..:.|||::.|:.:
Human   983 DLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEM 1047

  Fly   350 TTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELAKDVAGAEALLERHQEHKGEID 414
            .|..:.|:..|.|:..|.:||.|..|..||::..:..|:::::...:..||.||.:|:..|.|||
Human  1048 KTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEID 1112

  Fly   415 AREDSFKLTTESGQKLLEREHYAA-AEIQEKLAALENDKSSLLSLWEDRRILYEQCMDLQLFYRD 478
            ..|:.::...:.|:.:.:.:..|. ..::::|.||:...:.|..:||:|:.|..|....|.|.||
Human  1113 NYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRD 1177

  Fly   479 TEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIKALDIFATKLIDGQHYA 543
            |:||:.::..||..||:.::..:|:..||.|||.|||..::.|.||||.|:.....:|:...:..
Human  1178 TKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNIN 1242

  Fly   544 ADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFERDCDETKGWISEKLKFATDDSYLDPT 608
            :|.:.::...:..|....:|.:|:....|:|:...|:|.:||.|...||:||:..|.|.||.:..
Human  1243 SDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEAR 1307

  Fly   609 NLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAADQINTRMQEIVVLWETLVQASDKK 673
            ||:.|..|||.|..||.:||..::.|...|.:||.::......:..::..:..:||.|...:..|
Human  1308 NLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTK 1372

  Fly   674 GTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMAHQDRIE 738
            ..:|.:|.:.:.|.::..|::.||..:|.|:.|:|:|||||||..|.||..:||..:...:..||
Human  1373 AQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIE 1437

  Fly   739 SIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAPMGERKQHLLDSLQVQQLFRDLEDEAAWI 803
            .::..|....:.|. ..|.:.:|...:..::..|..|:.|||.:||.|.::.|..||:|||..|:
Human  1438 ELQSQAQALSQEGK-STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWV 1501

  Fly   804 REKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLNVISSGENMLKD-QPFASDDIRQR 867
            .|:.|:|.||:.|.:|..||.||||:|.:..||..|:.|:.::....:|::.| ...:::.||||
Human  1502 GERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQR 1566

  Fly   868 LEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEAESWMREKEPIATGSDYGKDEDSSEALL 932
            |..|::.|..|.|::.:|.:.|:::.:|.||:.||.|||:||.|:|......:..|||.|:.::|
Human  1567 LADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSML 1631

  Fly   933 KKHEALVSDLEAFGNTIQALQEQAKNCRQQETPVVDITGKECVVALYDYTEKSPREVSMKKGDVL 997
            |||:.|...:|.:..|:..|.:                                           
Human  1632 KKHQILEQAVEDYAETVHQLSK------------------------------------------- 1653

  Fly   998 TLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLSASQQNLVDNH----SIAKRQNQINSQYDNL 1058
                                               .|:..:.|:|    .|:.||::::..|..|
Human  1654 -----------------------------------TSRALVADSHPESERISMRQSKVDKLYAGL 1683

  Fly  1059 LALARERQNKLNETVKAYVLVREAADLAQWIRDKE----NHAQIADVVGEDLEEVEVLQKKFDDF 1119
            ..||.||:.||:|..:.:.|.||..||.|||.::|    :|.     :|:|.|.|.:||::|.:|
Human  1684 KDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHE-----LGQDYEHVTMLQERFREF 1743

  Fly  1120 -NDDLKANEVRLANMNEIAVQLTSLGQTEAALKIQTQMQDLNEKWNNLQTLTAEKASQLGSAHEV 1183
             .|.....:.|:..:|.:|.:|.:.|.::|| .|......|||.|.:|..|...:...|.:::|:
Human  1744 ARDTGNIGQERVDTVNHLADELINSGHSDAA-TIAEWKDGLNEAWADLLELIDTRTQILAASYEL 1807

  Fly  1184 QRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDKIRQLDETANRLM 1248
            .:|:.|..|....|.:|...| .::||:|..:|:||||.|...|.|:.||..::|||.|.|.||.
Human  1808 HKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQ 1871

  Fly  1249 QSHP-DTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRFLSDYRDLLAWINSMMSLVTS 1312
            .::. |.|:....::.|:.|.|..::....:|:.:|:|:.|..||.|..|||:.|:..::..:.:
Human  1872 AAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEA 1936

  Fly  1313 DELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAASTSSIASPSGDEEHRTEIDARAGTFGA 1377
            .|...||:..|.|:..||..:|                                |||||..:|..
Human  1937 QEKPRDVSSVELLMNNHQGIKA--------------------------------EIDARNDSFTT 1969

  Fly  1378 FEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLYMRDCELAESWMS 1442
            ..:.|..||...||||.|||||:..|.:.|:::...|.:|...|...|::..:.||..:||:|:.
Human  1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLL 2034

  Fly  1443 AREAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQTVADQLIAQNHYASNLVDEKRK 1507
            .:|.:|::.:...:...||.|||:||.|:|:....:::.:||:.:.         ...|::.:|:
Human  2035 GQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLT---------TLELLEVRRQ 2090

  Fly  1508 QVLERWRHLKEGLIEKRSRLGDEQTLQQFSRDADEIENWIAEKLQLATEESYKDPANIQSKHQKH 1572
            |..|          |::.|....:...:.|.:|:..:.|...|.:..::...  ||.        
Human  2091 QEEE----------ERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGL--PAE-------- 2135

  Fly  1573 QAFEAELAANADRIQSVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEA 1637
                                          .||     .|:.:..|..| :.:..||:....||:
Human  2136 ------------------------------QGS-----PRMAETVDTSE-MVNGATEQRTSSKES 2164

  Fly  1638 N---------KQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQN---LMKKHQLVEADIVAH 1690
            :         |.:|.:.|           :|..|.....::..|.|.   |.:||:.     .||
Human  2165 SPIPSPTSDRKAKTALPA-----------QSAATLPARTQETPSAQMEGFLNRKHEW-----EAH 2213

  Fly  1691 EDRIKD---------MNNQADSLVESGQFDTAGIQEKRQSINERYERICNLAAHR-------QAR 1739
            ..:...         :|||.....:..:...:||....:......|.:|.:|...       :.|
Human  2214 NKKASSRSWHNVYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLR 2278

  Fly  1740 LNEALTLHQFFRDIADEE---SWIKEKKLLVGSDDY 1772
            ||:.   :::.....|:|   :||:.....:.||.:
Human  2279 LNDG---NEYLFQAKDDEEMNTWIQAISSAISSDKH 2311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 0/51 (0%)
SPEC 1074..1287 CDD:238103 69/218 (32%)
SPEC 1182..1425 CDD:238103 74/243 (30%)
SPEC 1426..1638 CDD:238103 39/211 (18%)
SPEC 1533..1744 CDD:238103 38/238 (16%)
SPEC 1646..1850 CDD:238103 27/149 (18%)
SPEC 1852..2062 CDD:238103
SPEC 1958..2176 CDD:238103
SPEC 2072..2296 CDD:238103
EFh 2311..2379 CDD:238008
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103 67/315 (21%)
SPEC 154..364 CDD:238103 76/210 (36%)
SPEC 261..470 CDD:238103 74/210 (35%)
SPEC 471..680 CDD:238103 66/208 (32%)
SPEC 682..893 CDD:238103 72/211 (34%)
Spectrin 893..>961 CDD:395348 24/67 (36%)
SPTBN1NP_003119.2 Actin-binding 2..275
CH_SPTBN1_rpt1 3..156 CDD:409165
SAC6 48..>530 CDD:227401
CH_SPTB_like_rpt2 173..277 CDD:409097
Spectrin 1. /evidence=ECO:0000255 303..411
Spectrin 2. /evidence=ECO:0000255 423..525
SPEC 530..743 CDD:238103 45/149 (30%)
Spectrin 3. /evidence=ECO:0000255 530..636 7/42 (17%)
Spectrin 4. /evidence=ECO:0000255 639..742 35/102 (34%)
SPEC 642..849 CDD:238103 36/206 (17%)
Spectrin 5. /evidence=ECO:0000255 745..847 1/101 (1%)
Spectrin 6. /evidence=ECO:0000255 850..952 28/101 (28%)
SPEC 851..1061 CDD:238103 75/209 (36%)
Spectrin 7. /evidence=ECO:0000255 957..1060 45/102 (44%)
SPEC 958..1169 CDD:238103 74/210 (35%)
Spectrin 8. /evidence=ECO:0000255 1063..1166 28/102 (27%)
Spectrin 9. /evidence=ECO:0000255 1170..1258 29/87 (33%)
SPEC 1171..1380 CDD:238103 66/208 (32%)
Spectrin 10. /evidence=ECO:0000255 1276..1376 32/99 (32%)
SPEC 1381..1592 CDD:238103 72/211 (34%)
Spectrin 11. /evidence=ECO:0000255 1381..1482 31/101 (31%)
Spectrin 12. /evidence=ECO:0000255 1486..1590 38/103 (37%)
Interaction with ANK2. /evidence=ECO:0000269|PubMed:15262991 1563..2093 180/655 (27%)
SPEC 1593..1805 CDD:238103 73/295 (25%)
SPEC 1806..2027 CDD:238103 77/253 (30%)
Spectrin 2017..>2075 CDD:395348 17/57 (30%)
Spectrin 17. /evidence=ECO:0000255 2018..2097 23/97 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2089..2196 25/173 (14%)
Mediates interaction with CAMSAP1. /evidence=ECO:0000269|PubMed:24117850 2149..2177 6/28 (21%)
PH_beta_spectrin 2200..2305 CDD:269975 20/112 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2309..2364 1/3 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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