DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alpha-Spec and SPTB

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_001020029.1 Gene:SPTB / 6710 HGNCID:11274 Length:2328 Species:Homo sapiens


Alignment Length:1859 Identity:480/1859 - (25%)
Similarity:841/1859 - (45%) Gaps:288/1859 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 IQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQAAS-EESYRDPTNL 81
            |:.|.::|.::::..|......::.|:|:..|..|:.|||:|::|:.:..:..| |:..:|....
Human   714 IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT 778

  Fly    82 QAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWELLLSRLAEKGL 146
            :|..:||:.|..|:......:..|:...|. ..::...|..:..||..|.:|::.::::...:..
Human   779 RALGKKHKDFLEELEESRGVMEHLEQQAQG-FPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQ 842

  Fly   147 KLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQKDMASQEYRVTEV 211
            :||:||.|.....:.:....|:.:||.::...|....||.:||:|.:||...::|.:...::..|
Human   843 RLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907

  Fly   212 NQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNRDADETVAWIAE 276
            |..|:.||:.|||....:.:.::.||..||..:.|...|:|.:..|..:..:..|.:||..||.:
Human   908 NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITD 972

  Fly   277 K-DVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLCSIHADHSDQIRDKQA 340
            | .||.|:.|.|||||.:.|:|||..|:|||:||::.:|..|..|:|:|...|.:..:.|..:|.
Human   973 KTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQK 1037

  Fly   341 EIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELAKDVAGAEALLER 405
            .:...||.|....:.::..|.|...|..||.|..|..:|::..:..::::::.:.:..||.||::
Human  1038 HLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQ 1102

  Fly   406 HQEHKGEIDAREDSFKLTTESGQKLLERE---HYAAAEIQEKLAALENDKSSLLSLWEDRRILYE 467
            |...|.|||..:||::...|||:|:::.:   .|..  :.::|..|:...::|..:||.|.....
Human  1103 HAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLL--LGQRLEGLDTGWNALGRMWESRSHTLA 1165

  Fly   468 QCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIKALDIF 532
            ||:..|.|.:|.:||:..::.||..||:.:..|||::.||.|:|.|||..|:....:|:.:....
Human  1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDS 1230

  Fly   533 ATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFERDCDETKGWISEKLK 597
            ..||:...:..:|.:.::.|::..|.....||:.:...||.|:...|.|.::|.|...||::||.
Human  1231 GNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLL 1295

  Fly   598 FATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAADQINTRMQEIVVL 662
            .:.|.||.:..||:.|..|||.|..||.:::..:|:|...|.:|::::......::.:::.:..|
Human  1296 TSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRL 1360

  Fly   663 WETLVQASDKKGTKLNEACQQQQFN-RTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHALL 726
            |:.| ||:.|:.|:...|.:..... :|..|:..|:|.:|.||.|:|.|||||||..:..|...:
Human  1361 WDEL-QATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRV 1424

  Fly   727 EADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAPMGERKQHLLDSLQVQQ 791
            |..|...::.:..:........|.|. |||.      ::..|:..|..|:|.||:.|..|....|
Human  1425 EDQVNVRKEELGELFAQVPSMGEEGG-DADL------SIEKRFLDLLEPLGRRKKQLESSRAKLQ 1482

  Fly   792 LFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLNVISSGENMLKD 856
            :.||||||..|:.|:.|:|.|.:.|.:|..||..:||:|.:..||..|..|:.:|:..|:.:::.
Human  1483 ISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEA 1547

  Fly   857 QPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEAESWMREKEPIATGSDY 921
            ......|:.:||..||..|:.|:|.::.|.|.|.|:.:|.||:.||:|||:|:.|:|......:.
Human  1548 AEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEI 1612

  Fly   922 GKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETPVVDITGKECVVALYDYTEKSP 986
            .|||:.:..:||:|......:|.:|..|:.|..:|                              
Human  1613 PKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRA------------------------------ 1647

  Fly   987 REVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLSASQQNLVDNHSIAKRQNQI 1051
                                         ||.:.|.:               .:...|.:.|.|:
Human  1648 -----------------------------QGLLSAGH---------------PEGEQIIRLQGQV 1668

  Fly  1052 NSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQIADVVGEDLEEVEVLQKKF 1116
            :..|..|..:|.||:.||......:.|.||..||.|||.:||..|...: :|:|.:.|.:|:.||
Human  1669 DKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKF 1732

  Fly  1117 DDFNDDLKA-NEVRLANMNEIAVQLTSLGQTEAALKIQTQMQDLNEKWNNLQTLTAEKASQLGSA 1180
            .||..:..| .:.|:.|:|....:|...|.:||| .|......|||.|.:|..|...:...|.::
Human  1733 RDFARETGAIGQERVDNVNAFIERLIDAGHSEAA-TIAEWKDGLNEMWADLLELIDTRMQLLAAS 1796

  Fly  1181 HEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDKIRQLDETAN 1245
            :::.|:.....|....|.||...| .:|:|.|..:.::..|.|...||:|..|..:::|..:.|.
Human  1797 YDLHRYFYTGAEILGLIDEKHREL-PEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860

  Fly  1246 RLMQSHP-DTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRFLSDYRDLLAWINSMMSL 1309
            ||..::. :.||....|::|::..|..::.....|:.:|:|:.|..||.|..||||:|:.|::..
Human  1861 RLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQ 1925

  Fly  1310 VTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAASTSSIASPSGDEEHRTEIDARAGT 1374
            :.:.|...||:..|.|::.||          ||::                      ||:.|:..
Human  1926 IETQERPRDVSSVELLMKYHQ----------GINA----------------------EIETRSKN 1958

  Fly  1375 FGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLYMRDCELAES 1439
            |.|..:.|..|||..|.||.||:||::.:...|:::.:.|..|..:|...|::..:.||..:||:
Human  1959 FSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEA 2023

  Fly  1440 WMSAREAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQTVADQLIAQNHYASNLVDE 1504
            |:.|:|.:|.:.|..:...:||.|||:||.|:|:.....::.|||:            ....::.
Human  2024 WLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALE------------KPTTLEL 2076

  Fly  1505 KRKQVLERWRHLKEGLIEKRSRLGDEQTLQQFSRDADEIENWIAEKLQLATEESYKDPANIQ--- 1566
            |.:|:.||          .....|.::...:.:.:|....:...|:.....||. ..|.|:|   
Human  2077 KERQIAER----------PAEETGPQEEEGETAGEAPVSHHAATERTSPGEEEG-TWPQNLQQPP 2130

  Fly  1567 --SKHQKHQAFEAELAANADRIQSVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQWEYLTHKTTE 1629
              .:|:                           |.::.:|.|....:.|.::.|           
Human  2131 PPGQHK---------------------------DGQKSTGDERPTTEPLFKVLD----------- 2157

  Fly  1630 KSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKKHQLVEADIVAHEDRI 1694
              ..|.|.::..|                 |....|.|:.:.....|.:||.|            
Human  2158 --TPLSEGDEPAT-----------------LPAPRDHGQSVQMEGYLGRKHDL------------ 2191

  Fly  1695 KDMNNQADSLVESGQFDTAGIQEKRQSINERYERICNLAAHRQARLNEALTLHQFFRDIADEESW 1759
            :..|.:|.:                :|.|..|   |.|.       |..||   |::|       
Human  2192 EGPNKKASN----------------RSWNNLY---CVLR-------NSELT---FYKD------- 2220

  Fly  1760 IKEKKLLVGSDDYGRDLTGVQNL---------KKKHK-RLEAELGS--------HEPAIQAVQEA 1806
              .|.|.:|...:|.:...:::.         ||||. :|....||        .|..:..:|..
Human  2221 --AKNLALGMPYHGEEPLALRHAICEIAANYKKKKHVFKLRLSNGSEWLFHGKDEEEMLSWLQGV 2283

  Fly  1807 GEKLMDVSNLGVPEIEQRLKALNQAWAELKNLAATRGQK 1845
            ...:.:..::       |:||.:.....|....|:.|:|
Human  2284 STAINESQSI-------RVKAQSLPLPSLSGPDASLGKK 2315

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 3/51 (6%)
SPEC 1074..1287 CDD:238103 63/214 (29%)
SPEC 1182..1425 CDD:238103 66/243 (27%)
SPEC 1426..1638 CDD:238103 41/216 (19%)
SPEC 1533..1744 CDD:238103 31/215 (14%)
SPEC 1646..1850 CDD:238103 39/218 (18%)
SPEC 1852..2062 CDD:238103
SPEC 1958..2176 CDD:238103
SPEC 2072..2296 CDD:238103
EFh 2311..2379 CDD:238008
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103 54/210 (26%)
SPEC 154..364 CDD:238103 67/210 (32%)
SPEC 261..470 CDD:238103 67/212 (32%)
SPEC 471..680 CDD:238103 62/208 (30%)
SPEC 682..893 CDD:238103 69/211 (33%)
Spectrin 893..>961 CDD:395348 22/67 (33%)
SPTBNP_001020029.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
Actin-binding 2..275
SAC6 48..>438 CDD:227401
Spectrin 1. /evidence=ECO:0000255 303..411
Spectrin 422..525 CDD:306853
Spectrin 2. /evidence=ECO:0000255 423..525
Spectrin 3. /evidence=ECO:0000255 529..635
SPEC 530..742 CDD:238103 5/27 (19%)
Spectrin 4. /evidence=ECO:0000255 638..741 5/26 (19%)
SPEC 641..848 CDD:238103 30/134 (22%)
Spectrin 5. /evidence=ECO:0000255 744..846 23/102 (23%)
SPEC 745..954 CDD:238103 54/209 (26%)
Spectrin 6. /evidence=ECO:0000255 851..950 27/98 (28%)
SPEC 955..1168 CDD:238103 67/214 (31%)
Spectrin 7. /evidence=ECO:0000255 956..1058 36/101 (36%)
Spectrin 8. /evidence=ECO:0000255 1062..1165 28/104 (27%)
SPEC 1170..1379 CDD:238103 63/209 (30%)
Spectrin 9. /evidence=ECO:0000255 1170..1257 26/86 (30%)
Spectrin 10. /evidence=ECO:0000255 1275..1375 31/100 (31%)
SPEC 1385..1475 CDD:197544 30/96 (31%)
Spectrin 11. /evidence=ECO:0000255 1389..1465 25/82 (30%)
Spectrin 12. /evidence=ECO:0000255 1481..1582 36/100 (36%)
SPEC 1485..1690 CDD:238103 71/278 (26%)
Spectrin 13. /evidence=ECO:0000255 1585..1688 35/176 (20%)
Spectrin 14. /evidence=ECO:0000255 1690..1793 35/104 (34%)
SPEC 1691..1901 CDD:238103 62/212 (29%)
Spectrin 15. /evidence=ECO:0000255 1797..1899 25/102 (25%)
SPEC 1798..2005 CDD:238103 65/239 (27%)
Spectrin 16. /evidence=ECO:0000255 1906..2006 37/131 (28%)
Spectrin 17. /evidence=ECO:0000255 2013..2075 21/73 (29%)
Spectrin 2013..>2070 CDD:306853 21/68 (31%)
PH_beta_spectrin 2181..2286 CDD:269975 29/154 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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