DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Spec and SPTAN1

DIOPT Version :9

Sequence 1:	NP_001261286.1	Gene:	alpha-Spec / 38231	FlyBaseID:	FBgn0250789	Length:	2457	Species:	Drosophila melanogaster
Sequence 2:	NP_001362247.1	Gene:	SPTAN1 / 6709	HGNCID:	11273	Length:	2510	Species:	Homo sapiens

Alignment Length:	2535	Identity:	1597/2535 - (62%)
Similarity:	1953/2535 - (77%)	Gaps:	112/2535 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MENFTPKEVKILETVEDIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHE 65
            ::...|..||:|||.|||||||:|||.||:.||..:..:|:|||||.|||:|:|||:|||.||.|
Human    10 VQKMDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 74

  Fly    66 KLQAASEESYRDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDEL 130
            |||.||:|:|:||||||.|:||||||||||.|:|.|||.||.||..||::.|||||:|:.||.||
Human    75 KLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMEL 139

  Fly   131 HKLWELLLSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFD 195
            |:.|||||.::.|||:||.||..|||:||:||:||.||.|||..||::|.|||||||||||:||:
Human   140 HRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFE 204

  Fly   196 EFQKDMASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEI 260
            |||.|||:.|.||.||||.|.||:|:.|||.:.|..:::|:|.||||||.||:.||.|||||.|:
Human   205 EFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEV 269

  Fly   261 QRFNRDADETVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLC 325
            ||||||.|||::||.||:.:::|||:||||||||||.|||||:|||||||||||..|.|||.||.
Human   270 QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQ 334

  Fly   326 SIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISAD 390
            ..|...:.||:.|:.|:...|:.:.|.|.||..:|::||.|.|||||||||.||:..|||:|:||
Human   335 QSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINAD 399

  Fly   391 ELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREHYAAAEIQEKLAALENDKSSL 455
            |||.|||||||||:|||||||||||.|||||...||||.||...|||:.|::|||..|..::::|
Human   400 ELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAAL 464

  Fly   456 LSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLA 520
            |.|||.||..||||||||||||||||.|.||:||||||.||||||||||||||:||||||||||:
Human   465 LELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLS 529

  Fly   521 AQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFERDC 585
            ||||||.|||.||||||...|||.:|||.||..||:||.||.|::.:||..|.||...|||.||.
Human   530 AQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDS 594

  Fly   586 DETKGWISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAAD 650
            ||.|.|::||:|.|||::|.||:||.||:||||.||.||:||:|||:.:...|.:||:..|||.|
Human   595 DELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKD 659

  Fly   651 QINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTS 715
            ::..||.|::.||:.|::|::.||.||.||.|||||||.:|||||||.|:||.|.|:|:|||||:
Human   660 EVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTN 724

  Fly   716 VQNLQKKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAPMGERK 780
            |||||||||||||||.||||||:.|.:.|.:|.::|||||:||:.|:..|.|||.||..||..||
Human   725 VQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARK 789

  Fly   781 QHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLN 845
            |.|.|||::||||||:|||..|||||||||||||||:||||||||:|||||:.|||..||.|:..
Human   790 QKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 854

  Fly   846 VISSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEAESWMR 910
            |...|..|:::..||::|::.:|..|.::|..||.|:|||:|||:|||||.||||||||||||||
Human   855 VTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 919

  Fly   911 EKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETPVVDITGKECV 975
            |||||...:||||||||:||||||||||:|||.|:|::||||:|||::||||..|..|.||||.|
Human   920 EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELV 984

  Fly   976 VALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLSASQQNLVD 1040
            :|||||.|||||||:|||||:||||||.||||||||||||||||||||:||:|...|||::||::
Human   985 LALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLE 1049

  Fly  1041 NH-SIAKRQNQINSQ--------------------YDNLLALARERQNKLNETVKAYVLVREAAD 1084
            .. |||.||.||::|                    |.:||.|..:|:..|.::.|.::|.|||.:
Human  1050 EQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANE 1114

  Fly  1085 LAQWIRDKENHAQIADVVGEDLEEVEVLQKKFDDFNDDLKANEVRLANMNEIAVQLTSLG----- 1144
            |.|||.:|| .|..::.||.|||:|||||||||||..||||||.||.::|::|..|.|.|
Human  1115 LQQWINEKE-AALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEE 1178

  Fly  1145 ----------------QTE---------AALKIQT-----QMQDLNEKWNNLQTLTAEKASQLGS 1179
                            :|:         |.|.:.|     .:::|||:|.:||.|..|::..|||
Human  1179 VQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGS 1243

  Fly  1180 AHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDKIRQLDETA 1244
            ||||||||||.||||:||.||..|||.|:.|.||.|||.|||||||.|||||||.||:..|.|||
Human  1244 AHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETA 1308

  Fly  1245 NRLMQSHPDTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRFLSDYRDLLAWINSMMSL 1309
            .||:||||::||....|..|:|:.|..:..::..||.||.||:||||||||:|||::|||.:..|
Human  1309 ERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGL 1373

  Fly  1310 VTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAASTSSIASPSGDEEHRTEIDARAGT 1374
            |:|||||.||||||||:||||                                ||||||||||||
Human  1374 VSSDELAKDVTGAEALLERHQ--------------------------------EHRTEIDARAGT 1406

  Fly  1375 FGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLYMRDCELAES 1439
            |.||||||.:||...||||||||:|::.|.:.|.||||||.:||:.|:|.|:|||:.||||.||:
Human  1407 FQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAEN 1471

  Fly  1440 WMSAREAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQTVADQLIAQNHYASNLVDE 1504
            ||:|||||||.:|..::..:||||||||||||||||..|:||||||..||||||..|||...:..
Human  1472 WMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISS 1536

  Fly  1505 KRKQVLERWRHLKEGLIEKRSRLGDEQTLQQFSRDADEIENWIAEKLQLATEESYKDPANIQ--- 1566
            :|.:||:|||.||..:|||||:||:.|||||||||.||||.||:||||.|::||||||.|||
Human  1537 RRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSK 1601

  Fly  1567 --SKHQKHQAFEAELAANADRIQSVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQWEYLTHKTTE 1629
              |||||||||||||.||||||:.|:.||.:||::..|:||||||:.||..:||||::|..|:.|
Human  1602 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAE 1666

  Fly  1630 KSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKKHQLVEADIVAHEDRI 1694
            ||.||||||||:.:...:||.||||.|||:||.:||.|||||||.||:|||||:||||.|||||:
Human  1667 KSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRL 1731

  Fly  1695 KDMNNQADSLVESGQFDTAGIQEKRQSINERYERICNLAAHRQARLNEALTLHQFFRDIADEESW 1759
            ||:|:|||||:.|..|||:.:::||.:||.|:::|.::||.|:|:|||:..|||||||:.|||||
Human  1732 KDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESW 1796

  Fly  1760 IKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGSHEPAIQAVQEAGEKLMDVSNLGVPEIEQR 1824
            ||||||||||:||||||||||||:||||||||||.:||||||.|.:.|:||.|.:.:|..||:||
Human  1797 IKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQR 1861

  Fly  1825 LKALNQAWAELKNLAATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLLSVEDYGDSMAAVQGLL 1889
            |....:.|.|||.|||.|||:|:|||.||||:|.||||||||.||..|::.|||||::||:||||
Human  1862 LAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL 1926

  Fly  1890 KKHDAFETDFTAHKDRCSLICDQGSELVEAKNHHGESIAQRCQQLRLKLDNLSALAARRKGALLD 1954
            |||:|||||||.||||.:.:|..|.:|::..|||.|:|:.:.:.|..|:.:|...||:||..|.:
Human  1927 KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE 1991

  Fly  1955 NSAYLQFMWKADVVESWIDDKENYVRSDEFGRDLSTVQTLLTKQETFDAGLNAFEQEGIHNITAL 2019
            |||:|||.||||||||||.:|||.:::|::|||||:|||||||||||||||.||:||||.|||||
Human  1992 NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITAL 2056

  Fly  2020 KDQLINASHAQSPAILKRHGDVIARWQKLRDASNTRKDRLLAMQEQFRQIEELYLTFAKKASAFN 2084
            ||||:.|.|.||.||..||..::.||.:|...|..||.:||..|..||::|:|:|||||||||||
Human  2057 KDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFN 2121

  Fly  2085 SWFENAEEDLTDPVRCNSIEEIRALRDAHAQFQASLSSAEADFKALAALDQKIKSFNVGPNPYTW 2149
            ||||||||||||||||||:|||:|||:||..|::|||||:|||..||.||::||||.|..|||||
Human  2122 SWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTW 2186

  Fly  2150 FTMEALEETWRNLQKIIEERDGELAKEAKRQEENDKLRKEFAKHANLFHQWLTETRYYML---GY 2211
            |||||||||||||||||:||:.||.||.:|||||||||:|||:|||.||||:.|||.|:|   .|
Human  2187 FTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGIAY 2251

  Fly  2212 NR-------------QGTS-MMEGSGSLEQQLEALRVKATEVRARRVDLKKIEELGALLEEHLIL 2262
            .|             .|.| |:|.||:||.||||.:.|..|:||.|..|||||:|||.:||.|||
Human  2252 RRVIRVYQYEVGDDLSGRSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALIL 2316

  Fly  2263 DNRYTEHSTVGLAQQWDQLDQLSMRMQHNLEQQIQARNHSGVSEDSLKEFSMMFKHFDKDKSGKL 2327
            ||:|||||||||||||||||||.|||||||||||||||.:||:|::|||||||||||||||||:|
Human  2317 DNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRL 2381

  Fly  2328 NHQEFKSCLRALGYDLPMVEEGQPDPEFEAILDVVDPNRDGYVSLQEYIAFMISKETENVQSYEE 2392
            ||||||||||:|||||||||||:||||||||||.|||||||:||||||:|||||:|||||:|.||
Human  2382 NHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEE 2446

  Fly  2393 IENAFRAITAADRPYVTKEELYCNLTKDMADYCVQRMKPFSEPRSGQPIKDALDYIDFTRTLFQN 2457
            ||:||||:::..:|||||||||.|||::.|||||..|||:.:.: |:.:..|.||::|||:||.|
Human  2447 IESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGK-GRELPTAFDYVEFTRSLFVN 2510

Fly 2458 2457
Human 2511 2510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Spec	NP_001261286.1	SH3_Alpha_Spectrin	974..1026	CDD:212742	44/51 (86%)
		SPEC	1074..1287	CDD:238103	121/247 (49%)
		SPEC	1182..1425	CDD:238103	139/242 (57%)
		SPEC	1426..1638	CDD:238103	141/216 (65%)
		SPEC	1533..1744	CDD:238103	138/215 (64%)
		SPEC	1646..1850	CDD:238103	134/203 (66%)
		SPEC	1852..2062	CDD:238103	128/209 (61%)
		SPEC	1958..2176	CDD:238103	154/217 (71%)
		SPEC	2072..2296	CDD:238103	170/240 (71%)
		EFh	2311..2379	CDD:238008	61/67 (91%)
		EFhand_Ca_insen	2386..2456	CDD:400872	39/69 (57%)
		SPEC	48..258	CDD:238103	138/209 (66%)
		SPEC	154..364	CDD:238103	128/209 (61%)
		SPEC	261..470	CDD:238103	131/208 (63%)
		SPEC	471..680	CDD:238103	132/208 (63%)
		SPEC	682..893	CDD:238103	134/210 (64%)
		Spectrin	893..>961	CDD:395348	53/67 (79%)
SPTAN1	NP_001362247.1	Spectrin	56..158	CDD:334073	68/101 (67%)
		SPEC	162..373	CDD:238103	128/210 (61%)
		SPEC	374..584	CDD:238103	149/209 (71%)
		SPEC	480..690	CDD:238103	133/209 (64%)
		SPEC	691..902	CDD:238103	134/210 (64%)
		Spectrin	902..>983	CDD:334073	61/80 (76%)
		SH3_Alpha_Spectrin	983..1035	CDD:212742	44/51 (86%)
		SPEC	1104..1351	CDD:238103	121/247 (49%)
		SPEC	1246..1457	CDD:238103	139/242 (57%)
		SPEC	1458..1675	CDD:238103	141/216 (65%)
		Spectrin	1675..1777	CDD:334073	61/101 (60%)
		SPEC	1782..1991	CDD:238103	132/208 (63%)
		SPEC	1888..2099	CDD:238103	128/210 (61%)
		SPEC	1995..2213	CDD:238103	154/217 (71%)
		SPEC	2113..2350	CDD:238103	167/236 (71%)
		EFh	2365..2433	CDD:238008	61/67 (91%)
		EFhand_Ca_insen	2440..2508	CDD:312305	38/68 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159815
Domainoid	1	1.000	171	1.000	Domainoid score	I3765
eggNOG	1	0.900	-	-		E1_KOG0040
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2353
Inparanoid	1	1.050	3047	1.000	Inparanoid score	I16
Isobase	1	0.950	-	0	Normalized mean entropy	S2319
OMA	1	1.010	-	-		QHG51850
OrthoDB	1	1.010	-	-		D15759at33208
OrthoFinder	1	1.000	-	-		FOG0004911
OrthoInspector	1	1.000	-	-		oto91594
orthoMCL	1	0.900	-	-		OOG6_100348
Panther	1	1.100	-	-	LDO	PTHR11915
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3104
SonicParanoid	1	1.000	-	-		X5245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750