DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Spec and SPTA1

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_003117.2 Gene:SPTA1 / 6708 HGNCID:11272 Length:2419 Species:Homo sapiens


Alignment Length:2474 Identity:1128/2474 - (45%)
Similarity:1632/2474 - (65%) Gaps:72/2474 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MENFTPKEV-------KILETVEDIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADE 58
            ||.| |||.       |:|||.|:|||||::||:||..||....::.:|||||...|.||||||:
Human     1 MEQF-PKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64

  Fly    59 LESWIHEKLQAASEESYRDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESI 123
            |..||.||:...:::||.||||:|.|.||||:.||||...|..:..|:.|.:|.....|.|.|..
Human    65 LGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEET 129

  Fly   124 QVRLDELHKLWELLLSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVE 188
            :..::||..||:|||....|||.:|.:||...|::::|.:::.||.|||...|:.|.|:|.|..|
Human   130 KAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTE 194

  Fly   189 VLQRKFDEFQKDMASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEK 253
            ||.:||::||.::.::|.||.||||.|::..::.||:...|..::.|:|.||:||:.||:.||:.
Human   195 VLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKA 259

  Fly   254 LFGAHEIQRFNRDADETVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLG 318
            |..|..:|||.||..|.:.||.||:.||:|:|||:||.:.:.|...|:|:||:||.:.|||..|.
Human   260 LSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELC 324

  Fly   319 AEAQRLCSIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGM 383
            |:|::|...|...:.||::.:.::.:.|:.:...|..|.:||..:|:.|||.:||.:|..|:|..
Human   325 AKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEK 389

  Fly   384 KAIISADELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREHYAAAEIQEKLAAL 448
            .|.|:||||..||||.|.||:|||:||.|||:.:|.|:...|:||.|:...|.|:.|::||:..|
Human   390 TAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEIL 454

  Fly   449 ENDKSSLLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHE 513
            :|:.::||.||::|...||||:|..|||||:||.|:||::|||||.|||||:||.|.|||::|||
Human   455 DNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHE 519

  Fly   514 DFEKSLAAQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRY 578
            |||::..||||||..:|..|||||...||.::::...|..|||||.||:||::.||:||::|...
Human   520 DFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLL 584

  Fly   579 QQFERDCDETKGWISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIE 643
            |:...|.|:.|.||::|.|.|.|:.|.|..||..::||.|.||.||..||:::|:|...|.|:||
Human   585 QKLYEDSDDLKNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIE 649

  Fly   644 KQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSED 708
            ..|||:|.:.||:.|:..|||.|::|:.:|||:|:||.||.||....||::.||.::|.|:.|||
Human   650 GGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSED 714

  Fly   709 HGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNLSARYAALA 773
            :||.|..|||..:||.|||:.|.|.||:::.:...|..|.|.||.|:.:||.::.:|..|:.||.
Human   715 YGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALK 779

  Fly   774 APMGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINN 838
            .|:..||:.|||.|.:|.:.||.|||.|||:|.||.|.||..|:|||..:.|:.:|:.:|..|.:
Human   780 EPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIAS 844

  Fly   839 HEARLLNVISSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADAN 903
            ||.|:..:...|..|:::..||::|:..|:::|.:...:|:.::::|:.||:.::|..||.||.:
Human   845 HEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLH 909

  Fly   904 EAESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQE-TPVV 967
            |||:|:||||||...::||.||:::.||||||||.:.||.:||::::||:.||..|:||: .||.
Human   910 EAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVE 974

  Fly   968 DITGKECVVALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKI--DAG 1030
            .:.|::.|:||||:..:|||||:||||||||||:|.||||||||..|.||.|||.|::::  |..
Human   975 GVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEF 1039

  Fly  1031 LSASQQNLVDNHSIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENH 1095
            ....|:...:..:|.:||.||.:||.:||..|.||:.:|.:....::|..||.|:.:||::|:  
Human  1040 PMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK-- 1102

  Fly  1096 AQIADVVGEDLEEVEVLQKKFDDFNDDLKANEVRLANMNEIAVQLTSLG-QTEAALKIQTQMQDL 1159
               |:..|.:|::|..||||||:|..||..||.||.::|::|..|...| .|....:|:   |:|
Human  1103 ---AENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR---QEL 1161

  Fly  1160 NEKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHE 1224
            |.:|.:||.|..|:...|||||.|:.|||:.|:||:.|.:|..||:..|.|.||.|||.|||:||
Human  1162 NSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHE 1226

  Fly  1225 GVERDLAALRDKIRQLDETANRLMQSHPDTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDL 1289
            |.||||..|.||:..|.|||.||.:||||..|....::.|:||.|:.:..::..|||.|.::...
Human  1227 GFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKF 1291

  Fly  1290 QRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAASTSS 1354
            ..|||..|||..||:|:..:|:|.|||.|:||.|.|:||||                        
Human  1292 YLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQ------------------------ 1332

  Fly  1355 IASPSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRL 1419
                    |||.:::|.|.||.|.|.|..||:.:.|:|||||::|::.:...|:||||||.:|:.
Human  1333 --------EHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKK 1389

  Fly  1420 QLEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAAL 1484
            .|:|.|:||::..:|:..||||.|||..|.:||.::. .::|||:||.:|.||||...|.||..|
Human  1390 ILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSL-DSLEALMKKRDDLDKAITAQEGKITDL 1453

  Fly  1485 QTVADQLIAQNHYASNLVDEKRKQVLERWRHLKEGLIEKRSRLGDEQTLQQFSRDADEIENWIAE 1549
            :..|:.|||..|||...:..:.::||:||:.||..||::|::|||...|:||.||.:|:|.||:|
Human  1454 EHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISE 1518

  Fly  1550 KLQLATEESYKDPANIQSKHQKHQAFEAELAANADRIQSVLAMGGNLIDKKQCSGSEDAVQKRLT 1614
            .|..|.:|||||..|||.|:.|||.|..|:...::::..|:.:|.:||:...|.|:|:|::::|.
Human  1519 MLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLE 1583

  Fly  1615 QIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKK 1679
            |:.:.|::|..:|.:|..||.||::|:.:..:::|.:|||.|.|:||..:|..:||||..||:||
Human  1584 QLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKK 1648

  Fly  1680 HQLVEADIVAHEDRIKDMNNQADSLVESGQFDTAGIQEKRQSINERYERICNLAAHRQARLNEAL 1744
            |||:|.:::|.||.:||:|..|:.|:.||.|:...|.:|:.::|:|:..:..|||....:|.||.
Human  1649 HQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAY 1713

  Fly  1745 TLHQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGSHEPAIQAVQEAGEK 1809
            .|.|||:|:.||||||:||.:.|.|.||||||.|||||.|||||||.||.:||||||.|.:..||
Human  1714 ALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEK 1778

  Fly  1810 LMDVSNLGVPEIEQRLKALNQAWAELKNLAATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLLS 1874
            |.|.:.:|..||:.||....:.|.:||.||..||.||:|||.|.||:...|||||||.||..|..
Human  1779 LKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAV 1843

  Fly  1875 VEDYGDSMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSELV------EAKNHHGESIAQRCQQ 1933
            ..|.||::||.|.||.||:|.|.||..|:.|...:|.||.:::      |::|   :.|:.:.:.
Human  1844 RGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQN---KEISSKIEA 1905

  Fly  1934 LRLKLDNLSALAARRKGALLDNSAYLQFMWKADVVESWIDDKENYVRSDEFGRDLSTVQTLLTKQ 1998
            |..|..:|:...|..|..|.|:.|:.:|.|||||||:||.|||..::::..|.||....|||.||
Human  1906 LNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQ 1970

  Fly  1999 ETFDAGLNAFEQEGIHNITALKDQLINASHAQSPAILKRHGDVIARWQKLRDASNTRKDRLLAMQ 2063
            :|.||.|.:|:||.:..||.|||:||:|.|.||.||.:|:..::.||::|.:||...:.:||..|
Human  1971 DTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQ 2035

  Fly  2064 EQFRQIEELYLTFAKKASAFNSWFENAEEDLTDPVRCNSIEEIRALRDAHAQFQASLSSAEADFK 2128
            ...::.|:|::.||.||||.|:|.|..||:|::||.|.|:.|||.|:..|..|.|||:.|:||||
Human  2036 LPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFK 2100

  Fly  2129 ALAALDQKIKSFNVGPNPYTWFTMEALEETWRNLQKIIEERDGELAKEAKRQEENDKLRKEFAKH 2193
            .|..|||:||:..|..:||||.|:|.||.||::|..|||||:.||.||..||.:|.::.:||.::
Human  2101 CLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQN 2165

  Fly  2194 ANLFHQWLTETRYYMLGYNRQGTSMMEGSGSLEQQLEALRVKATEVRARRVDLKKIEELGALLEE 2258
            |:.|.||:.|||.|.|     ..|:::.:|:||.||||.:.|..|::|.:..|.||.:||..||:
Human  2166 ASTFLQWILETRAYFL-----DGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNLED 2225

  Fly  2259 HLILDNRYTEHSTVGLAQQWDQLDQLSMRMQHNLEQQIQARNHSGVSEDSLKEFSMMFKHFDKDK 2323
            .||||.:|   ||:|||||||||.||.:||||||||||||::..||||::|||||.::||||::.
Human  2226 ALILDIKY---STIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENL 2287

  Fly  2324 SGKLNHQEFKSCLRALGYDLPMVEEGQPDPEFEAILDVVDPNRDGYVSLQEYIAFMISKETENVQ 2388
            :|:|.|:||:||||.|.|.||||||.:.:|:||..||.|||.|.|||||::|.||:|.||:||::
Human  2288 TGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIK 2352

  Fly  2389 SYEEIENAFRAITAADRPYVTKEELYCNLTKDMADYCVQRMKPFSEPRSGQPIKDALDYIDFTRT 2453
            |.:||||||:|: |..:.|:|||::...||.:...:|...|:.:.:|| |:......||:.||.:
Human  2353 SSDEIENAFQAL-AEGKSYITKEDMKQALTPEQVSFCATHMQQYMDPR-GRSHLSGYDYVGFTNS 2415

  Fly  2454 LFQN 2457
            .|.|
Human  2416 YFGN 2419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 36/51 (71%)
SPEC 1074..1287 CDD:238103 93/213 (44%)
SPEC 1182..1425 CDD:238103 102/242 (42%)
SPEC 1426..1638 CDD:238103 89/211 (42%)
SPEC 1533..1744 CDD:238103 86/210 (41%)
SPEC 1646..1850 CDD:238103 103/203 (51%)
SPEC 1852..2062 CDD:238103 92/215 (43%)
SPEC 1958..2176 CDD:238103 107/217 (49%)
SPEC 2072..2296 CDD:238103 116/223 (52%)
EFh 2311..2379 CDD:238008 40/67 (60%)
EFhand_Ca_insen 2386..2456 CDD:400872 25/69 (36%)
SPEC 48..258 CDD:238103 89/209 (43%)
SPEC 154..364 CDD:238103 82/209 (39%)
SPEC 261..470 CDD:238103 91/208 (44%)
SPEC 471..680 CDD:238103 107/208 (51%)
SPEC 682..893 CDD:238103 84/210 (40%)
Spectrin 893..>961 CDD:395348 36/67 (54%)
SPTA1NP_003117.2 Spectrin 1. /evidence=ECO:0000255 53..155 45/101 (45%)
Spectrin 53..138 CDD:278843 37/84 (44%)
SPEC 159..370 CDD:238103 82/210 (39%)
Spectrin 2. /evidence=ECO:0000255 159..261 40/101 (40%)
Spectrin 3. /evidence=ECO:0000255 265..367 39/101 (39%)
SPEC 266..476 CDD:238103 91/209 (44%)
Spectrin 4. /evidence=ECO:0000255 371..474 48/102 (47%)
SPEC 477..687 CDD:238103 108/209 (52%)
Spectrin 5. /evidence=ECO:0000255 477..580 61/102 (60%)
Spectrin 6. /evidence=ECO:0000255 583..685 45/101 (45%)
SPEC 688..897 CDD:238103 84/208 (40%)
Spectrin 7. /evidence=ECO:0000255 688..790 43/101 (43%)
Spectrin 8. /evidence=ECO:0000255 794..896 36/101 (36%)
Spectrin 9. /evidence=ECO:0000255 900..969 37/68 (54%)
SPEC 902..>958 CDD:197544 30/55 (55%)
SH3 982..1033 CDD:302595 36/50 (72%)
Spectrin 1082..1179 CDD:278843 38/104 (37%)
Spectrin 10. /evidence=ECO:0000255 1087..1179 38/99 (38%)
Spectrin 11. /evidence=ECO:0000255 1185..1287 50/101 (50%)
SPEC 1186..1395 CDD:238103 101/240 (42%)
Spectrin 12. /evidence=ECO:0000255 1290..1392 50/133 (38%)
SPEC 1396..1606 CDD:238103 88/210 (42%)
Spectrin 13. /evidence=ECO:0000255 1396..1497 43/101 (43%)
Spectrin 14. /evidence=ECO:0000255 1501..1605 42/103 (41%)
SPEC 1608..1819 CDD:238103 104/210 (50%)
Spectrin 15. /evidence=ECO:0000255 1608..1711 41/102 (40%)
Spectrin 16. /evidence=ECO:0000255 1714..1817 60/102 (59%)
SPEC 1715..1926 CDD:238103 104/213 (49%)
Spectrin 17. /evidence=ECO:0000255 1820..1926 41/108 (38%)
Spectrin 18. /evidence=ECO:0000255 1929..2033 49/103 (48%)
SPEC 1930..2148 CDD:238103 107/217 (49%)
Spectrin 19. /evidence=ECO:0000255 2044..2146 55/101 (54%)
SPEC 2047..2260 CDD:238103 115/220 (52%)
Spectrin 20. /evidence=ECO:0000255 2158..2258 53/107 (50%)
EFh 2275..2343 CDD:298682 40/67 (60%)
EF-hand_7 2278..2343 CDD:290234 37/64 (58%)
EFhand_Ca_insen 2350..2418 CDD:285885 25/69 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11254
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51850
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 1 1.000 - - FOG0004911
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 1 1.100 - - O PTHR11915
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.930

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