DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Spec and Sptbn5

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:XP_036018336.1 Gene:Sptbn5 / 640524 MGIID:2685200 Length:3742 Species:Mus musculus


Alignment Length:2918 Identity:607/2918 - (20%)
Similarity:1095/2918 - (37%) Gaps:745/2918 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 TVEDIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQAASEESY-RD 77
            :||.:|.:...:...::......|.:|..||.:.:...|.|..:|.|:|:.|..|....... ||
Mouse   652 SVEVLQAKALALAELHHSLVSLVRARRTLLEQTLQRAQFLRSCEEEEAWLQEHRQLMETAVLDRD 716

  Fly    78 PTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWELLLSRLA 142
            .|.:...:|||:|.|.|:..|....|.|...|:....::.........|.:.:...|:||.:..|
Mouse   717 LTQIATALQKHKALETELHRHQAVCVDLMQRGRNFSVREPLTQPDPLERAEAVQGTWQLLWAGAA 781

  Fly   143 EKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQD--------LEHVEVLQ-------- 191
            .:..:||.||::.|:.....|...|:..::..:.:...|:|        |:|:.:.|        
Mouse   782 RRRARLQTALLIGQYFSDSAEAASWLFQRQKQLESASCGKDQADAEALLLQHLRLEQDVRAFAAE 846

  Fly   192 -RKFDE----------------------------------------------------------- 196
             |:.:|                                                           
Mouse   847 LRELEEQARAAAALVSHMVHTGTWKGSRLVSPTPNEEPPEDWKRLGRDTIGGPQGETQVLAAPGS 911

  Fly   197 ---------FQKDMASQEYRVTEVNQLADKLV-----------------------------QDGH 223
                     |.::.|...:::.|:.....::.                             .|.|
Mouse   912 HYSHQQIAFFSREEAPNTWKLEELGDSQSRMAIIHSIEKKPQVLSALGFLGEGPRTVLQAENDVH 976

  Fly   224 PERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNRDADETVAWIAEKDVVL--SSDDY 286
            ....||.:.:.::::.:::|:.||.:.:.:|..:..:..|.....|..:|: ||...|  :....
Mouse   977 FNSSTILQAQADVSQTYEKLRALAKLHRTRLEESIALFSFYSSCRELQSWL-EKQTALFQTLQPQ 1040

  Fly   287 GRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLCSIHADHSDQIRDKQAEIANYWQSL-- 349
            |.:|   :.:|.|:|.|...||..:...:.....|::|......|..:|:.:|.::...||.|  
Mouse  1041 GHNL---EVIQLKYENVLMTLATGKGHWAEAINTAEQLKQRCPGHISKIQQQQEDLKQRWQQLEA 1102

  Fly   350 --------TTKARERKQKLDES------------------------------------------- 363
                    .|:..|....|.||                                           
Mouse  1103 LKEEKLLQLTRGMEVCSLLQESEPIQAQLLNVISRLETLGTRSSGDSHHTLQQTQQKVLVLEKKI 1167

  Fly   364 YYLHR-------------------------------------------------FLADFRDLVSW 379
            .||.|                                                 .|.:.:.|:.|
Mouse  1168 SYLQRATIEVMESGSPESRLLWEQVLMLQSLLKQAQGQVARQIQVQTVARVQRGILQESQKLLLW 1232

  Fly   380 INGMKAIISADELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREHYAAAEIQEK 444
            ...::|.:.:.|..:..|.|...|.||...:.|....|:..:.....||.:...:...:.|:...
Mouse  1233 AEDIQAQLCSKEERQVEASALRPLRRHGTLQEETCLWEERLQQLEAQGQPVAVSDSPQSQEVASA 1297

  Fly   445 LAALENDKSSLLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALI 509
            |..|......|.:|||.|:..:.:.::||.|.::.:......|..||.|..::||:.:...::|:
Mouse  1298 LRLLGQHSQQLKALWEQRQQKFWEGLELQGFGQEVDDFMATCASHEALLQLDNLGEDIREAQSLL 1362

  Fly   510 KKHED---FEKSLAAQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRA---ALQEKSSKR 568
            ::|:.   ...:|.::.|.::|.   ..||: ..|.||  |::.|::|.:.:|   .:||:|.:|
Mouse  1363 QQHQGLGWLRSTLGSRAEALRAR---GEKLL-LSHPAA--VSKIRELLHSAQAQWTRVQERSEQR 1421

  Fly   569 RQLLEDSNRYQQFERDCDETKGWISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIED 633
            |..|..|.:.|::::..:....|:.||.....|:.....:|:..|::..:..:.||.|::..:|:
Mouse  1422 RVQLLASLQLQEWKQAEEGLMLWMEEKWPRVADERSQAGSNILQKLKWRKITKSELLASRRYMEE 1486

  Fly   634 ITNVGTELIEKQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLS 698
            :...|.||:....||.:.|..|:|.:...||.|....:.:|.:|.:..||.|....|:|::..:.
Mouse  1487 LQQAGKELLHSNPYAQEDIQDRLQSLNHKWEELNHKMEDRGDRLPQTRQQDQLLELIQDVQETME 1551

  Fly   699 EIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVAANKFIESGH--FDADNIRNK 761
            .:||.|.|.:.|:||.|.:.||::|..||       |:.:::....:..|...|  |.:..|..:
Mouse  1552 HLEGALQSTETGQDLCSSRRLQRQHCKLE-------DKSQALASKMDALISQTHNAFTSWTILEE 1609

  Fly   762 EGNLSARYAALAAPMGERKQHLLDSLQVQQ--LFRDLEDEAAWIREKEPIAASTNRGRDLIGVQN 824
            ......|:.:|.:.:..:.|.|..|:::.:  |..:|  |..|..|..|.||.....:......:
Mouse  1610 SQKCHQRFKSLQSKLATQHQQLQASVELYEFNLLSNL--ELTWAAEHMPNAALNCPAQCWHDAHS 1672

  Fly   825 LIKKHQAVLAEINNHEARLLNVISSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDL 889
            |.:||:.:.||:..|...:..|:|||:.:.......:..|.::.:.|:..|..|::...:|...|
Mouse  1673 LQRKHKMLQAEVKGHVRHMYRVLSSGQRLAASGHPRAQHIVEQCQKLESHWAGLEQACEERAHCL 1737

  Fly   890 DDSLQAHQYFADANEAESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQE 954
            ..::...|||.:.:|.|:|:.||.|:|:..|||.:|:::..|::||:.|..::..:.::::.|::
Mouse  1738 QQAVTVQQYFLNVSEMETWVEEKRPLASSQDYGSNEEATSGLIRKHQMLQQEVALYWSSMEDLEQ 1802

  Fly   955 QAKNCRQQETPVVDITGKECVVALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFV 1019
            :.:...:.|.|                                                :|.|.|
Mouse  1803 RFQTLAEFEAP------------------------------------------------ERLGVV 1819

  Fly  1020 PAAYIKKIDAGLSASQQNLVDNHSIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAAD 1084
            .    :|:.|                            |..||.||..:|..|::.:..:|||.|
Mouse  1820 R----EKLQA----------------------------LRKLADERGQELEGTLRLHEFMREAED 1852

  Fly  1085 LAQWIRDKENHAQIADVVGEDLEEVEVLQKKFDDFNDDLKANEVRLANMNEIAVQLTSLGQTEAA 1149
            |..|:..::..|:..|..|||.|.|..|..:|..|...::....|:.....:|..|...|.: ||
Mouse  1853 LQSWLSSRKQVARGGDTFGEDHEHVLQLCTEFTKFQYQVETGAQRVETCRLLAESLQERGHS-AA 1916

  Fly  1150 LKIQTQMQDLNEKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLR 1214
            .|...:.||:...|:.|..||..::..|..|....|.|.|:.|....|.|||.:|.| |:.:||.
Mouse  1917 PKAHQRQQDIQASWSELCQLTQARSRLLNDAEITLRVHGDLLEVLTQIQEKATSLPN-DVAQDLC 1980

  Fly  1215 SVQTLQRKHEGVERDLAALRDKIRQLDETANRLMQSHPDTAEQTYAKQKE--INEMWDQIITKST 1277
            .|:...::||.:||:||.:..::::|.:...|:.:..|.|......:||:  :.:.|:.:..:..
Mouse  1981 GVENQLQRHERLERELAGMEQQVQELMKAGGRVQELCPGTQALAAVQQKQQAVTQAWEALQLRME 2045

  Fly  1278 ARKEKLLDSYDLQRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGI 1342
            .||.:|...|.|.||.:..||..:|..|:...:..:|.:.:.......:..||...||:      
Mouse  2046 QRKAQLERGYLLVRFHTAVRDYTSWAASVHQELQMEEASWEPHSLLLRLRAHQWLWAEL------ 2104

  Fly  1343 SSAPGAAASTSSIASPSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAR 1407
                                :.:.|:..||...|.     ..||.|...|  ::::.:..|.:.|
Mouse  2105 --------------------KAKEELQQRATKMGQ-----QALLAAGTPA--KVQDGLRTLQEER 2142

  Fly  1408 EDLEKAWTERRLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDK 1472
            :.:.:||..::.:|:..|..|..:|.|......::|:||||.|....::...||.||:||..|.|
Mouse  2143 DQVFQAWALKQEKLQAMLQEQHLLRQCGHLVEVLTAQEAFLKASGLGSSVEEVEQLIRKHVIFQK 2207

  Fly  1473 AINGHEQKIAALQTVADQLIAQNHYASNLVDEKRKQV------------LERWRHLKEGLIEKRS 1525
            .:...::|:..|..|||.       ..:.::|:.|.:            ||....:|| |.|.|.
Mouse  2208 VLALQDKKVTGLNIVADG-------GESALNEQLKTISSPKGQNLFCHMLEHRAQVKE-LAESRG 2264

  Fly  1526 R-LGDEQTLQQFSRDADEIENWIAEKLQLATEESYKDPANIQS--KH-QKHQAFEAELAANADRI 1586
            : |.....:..|.|.|.:.|:||.:::|..  .::....|::.  || :|||||.||:.|....:
Mouse  2265 QALHTSLMIGNFVRAATQAEDWIQQRVQQL--RAWSPLGNLKDYLKHLRKHQAFRAEVQAQEQIL 2327

  Fly  1587 QSVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLD 1651
            .||...|..|:.:......|  |.:||..:.|.||.|....|.:...|:.....:.::..|...:
Mouse  2328 TSVAKQGEELLSQSHPQAGE--VSQRLEALRDLWEKLRQAVTLQGQALENRYNFQEFLQRVDLAE 2390

  Fly  1652 FWLGEVESLLTTEDSGKDLASVQNLMKKHQLVEADIVAHEDRIKDMNNQADSLVESGQFDTAGIQ 1716
            .|:.|.|.::.:.|.|.:|.....|.:  |:....:...:..||.:.|.:..|...|..::..|.
Mouse  2391 TWIQEKERMVNSCDIGLNLEHCLQLCR--QVRRLQVTVDDAHIKGIKNLSLQLKNQGPEESETIC 2453

  Fly  1717 EKRQSINERYERI-CNLAAHRQARLNEALTLHQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQ 1780
            :::..:|.|::.. .||..::| ||..||.:|:..|::.|....::||:.|:.:.:...||..||
Mouse  2454 QRQNQLNNRWKTFHGNLLLYQQ-RLEAALEIHRLSRELDDVIERLREKESLIWAPEGTEDLENVQ 2517

  Fly  1781 NLKKKHKRLEAELG--------------------------------------------------- 1794
            .|..:.|.|:.|:|                                                   
Mouse  2518 RLSWRQKVLQQEMGLIQTQVESLEGRIGRLCKESPEVAHSLRHKQQEMMDSWWKVWSKAQKWREL 2582

  Fly  1795 ---SHE----------------------------------------------------PAIQAVQ 1804
               .||                                                    .::..||
Mouse  2583 LDVGHEVQKLQTLLQDLQDWARGLQAEMATQGTPCSPVRIQYMLEEYRAYKVELDIRTESLNLVQ 2647

  Fly  1805 EAGEKLMDVSNLGVPEIEQRLKALNQAWAELKNLAATRGQKLDESLTYQQFLAQVEEEEAWITEK 1869
            ..|::|:........||.|.|.|:.|..:.|:.....|.|:|.::|..|.||..||:.|.|:..:
Mouse  2648 SMGQRLLASGYPQASEIHQTLAAVEQGLSSLRESWQGRQQQLQQALEQQLFLGSVEKAERWLDSE 2712

  Fly  1870 QQLLSVEDYGDSMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSELVEAKNHHGESIAQRCQQL 1934
            :..|:.|...|.:..|:.||.|....|....|..::...:......|.:..:....||..|||.|
Mouse  2713 EASLASEGVADPLVTVETLLSKLKRHEQGLKAQAEKIRALEATAHSLHQGGHSEARSILDRCQAL 2777

  Fly  1935 RLKLDNLSALAARRKGALLDNSAYLQ-FMWKADVVESWIDDKENYVRSDEFGRDLSTVQTLLTKQ 1998
            .|:.:.|:. .||.:|..|:....|: |:..::.|.:|:.:| :....||..:|.:|:||.|.||
Mouse  2778 LLRTEALTE-QARARGHQLEELRKLRTFLQDSNEVTAWLREK-SLAALDEGQQDPATMQTQLQKQ 2840

  Fly  1999 ETFDAGLNA-------FEQEGIHNITALKDQLINASHAQSPAILKRHGDVIARWQKLRDASNTRK 2056
            :.|.|.|:|       .:.||        .:|:...|..|..|..:..::...|.:|:.....:.
Mouse  2841 QNFQAELDASVHQQQEVQMEG--------QKLLQGGHPASETIRGQLEELGGLWDELQTNCQRKM 2897

  Fly  2057 DRL------LAMQEQFRQIEELYLTFAKKASAFNSWFENAEEDLTDPVRCNSI----------EE 2105
            .||      |.:|...:::|:              |.|:.|.:|..|||..::          ||
Mouse  2898 ARLQGALKVLHLQRMLKELEK--------------WLEHMEAELRVPVRSQALPRVGELLGAQEE 2948

  Fly  2106 IRALRDAHA--------QFQASLSSA--------------------------------------- 2123
            :.|..|..|        |.||.|...                                       
Mouse  2949 LEAAMDRQAKEVQELQGQSQACLQEGHCLAKDVEEQARQLLQRFQSLREPLQERRASLEAQRLLL 3013

  Fly  2124 ----EADFKALAALDQKIKSFNVGPNPYTWFTMEALEETWRNLQ------------------KII 2166
                :|| :.:|.:.:|:.|........:..|:..|:|..:||:                  |:|
Mouse  3014 QFFRDAD-EEMAWVQEKLPSATAQDYGQSLNTVRHLQEKHQNLENEIHSHKALSQVVTGTGHKLI 3077

  Fly  2167 EERDGELAKE--AKRQEEND----KLRKEFAKHANLFHQ----------------WLTETRYYM- 2208
            :.  |..|.|  |.|.::.:    :|..|.|:......|                ||.|..:.: 
Mouse  3078 QA--GHFATEEVAARVQQLEVALNRLETEAAQRRRRLQQALEAQQTLVELLEAGSWLAERDHILD 3140

  Fly  2209 ---LGYNRQGTSM-----------MEG-SGSLEQ---------------------QLEALRVKAT 2237
               ||.:.:.|..           :|| |..:||                     ||:|:|    
Mouse  3141 SEDLGQDAEATQALLRCLEATTRDLEGFSSRIEQLQQTVALLESGQTPGSPRVLAQLQAVR---- 3201

  Fly  2238 EVRARRVDLKKIEELGALLEEHLILDNRYTEHSTVGLAQQWDQLDQLSMRMQHNLEQQIQARNHS 2302
            |..||.  |::.|..|..|.|.|.|   |             ||:|.::.:...|..::......
Mouse  3202 EAHARL--LQRAESRGEALREQLHL---Y-------------QLEQEALLLDAWLTTKLAVAESQ 3248

  Fly  2303 GVSED--SLKEFSMMFKHFDKD--KSGKLNHQEFKSCLRALGYDLPMVEEGQPD--PEFEAILDV 2361
            ...:|  .:|....||..|:::  ..|:...|..:..:.:|       |.|.|.  |:.:|....
Mouse  3249 DYGQDLAGIKVLEDMFGAFNREVQSLGQAKMQTLRERMASL-------ERGAPRFYPQIQAQKCR 3306

  Fly  2362 VDPNRDGYVSLQEYIAFMISKETEN------VQSYEE---------------IENAFR 2398
            |....:|       :...|...|||      ::|:|:               :|.||:
Mouse  3307 VQAAWEG-------LNKAIKVRTENLAAACDLRSFEQAASELQRWIQEKTTLLEEAFQ 3357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 3/51 (6%)
SPEC 1074..1287 CDD:238103 61/214 (29%)
SPEC 1182..1425 CDD:238103 56/244 (23%)
SPEC 1426..1638 CDD:238103 64/227 (28%)
SPEC 1533..1744 CDD:238103 54/214 (25%)
SPEC 1646..1850 CDD:238103 55/310 (18%)
SPEC 1852..2062 CDD:238103 58/223 (26%)
SPEC 1958..2176 CDD:238103 61/310 (20%)
SPEC 2072..2296 CDD:238103 67/361 (19%)
EFh 2311..2379 CDD:238008 13/71 (18%)
EFhand_Ca_insen 2386..2456 CDD:400872 6/34 (18%)
SPEC 48..258 CDD:238103 50/324 (15%)
SPEC 154..364 CDD:238103 48/378 (13%)
SPEC 261..470 CDD:238103 52/312 (17%)
SPEC 471..680 CDD:238103 54/214 (25%)
SPEC 682..893 CDD:238103 52/214 (24%)
Spectrin 893..>961 CDD:395348 19/67 (28%)
Sptbn5XP_036018336.1 CH_SPTBN5_rpt1 83..207 CDD:409096
CH_SF 222..330 CDD:412120
SPEC 357..579 CDD:413338
SPEC 474..685 CDD:238103 7/32 (22%)
SPEC 585..791 CDD:238103 34/138 (25%)
SPEC 795..>856 CDD:197544 10/60 (17%)
SPEC <976..1111 CDD:413338 29/138 (21%)
SPEC 1223..1318 CDD:197544 22/94 (23%)
SPEC 1324..1532 CDD:238103 54/213 (25%)
SPEC 1538..1740 CDD:238103 50/210 (24%)
SPEC 1669..1838 CDD:238103 47/248 (19%)
SPEC 1842..2052 CDD:238103 60/211 (28%)
SPEC 1952..2160 CDD:238103 56/241 (23%)
SPEC 2161..2375 CDD:238103 64/225 (28%)
SPEC 2276..2481 CDD:238103 54/211 (26%)
SPEC 2484..2682 CDD:238103 28/197 (14%)
SPEC 2588..2797 CDD:238103 45/209 (22%)
SPEC 2800..3010 CDD:238103 47/232 (20%)
SPEC 3011..3222 CDD:238103 44/219 (20%)
SPEC 3223..3458 CDD:238103 30/165 (18%)
SPEC 3462..>3630 CDD:238103
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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