DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Spec and sptb

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:XP_005158906.1 Gene:sptb / 58040 ZFINID:ZDB-GENE-000906-1 Length:2481 Species:Danio rerio


Alignment Length:1719 Identity:467/1719 - (27%)
Similarity:818/1719 - (47%) Gaps:202/1719 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 KILETVEDIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKL-QAASEE 73
            |:.:.:.|:| |:.|.|.....|      :::.|:|::||..|:.|||:|::|:.:.: |.:|::
Zfish   845 KVQQRMNDVQ-RQWQQLEELAAF------RKQNLQDTQRFFQFQGDADDLKAWLVDAMRQMSSDD 902

  Fly    74 SYRDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTG----QEMINQQHFASESIQVRLDELHKLW 134
            ...|....|..::||:....|.:.:...|.:|....    :|:.|     :..||.||:::..::
Zfish   903 VGHDEYTTQRLLKKHRDLRDEAAKNGATIDALSKQANALPEELRN-----TPDIQGRLNDIRDMY 962

  Fly   135 -ELL-LSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEF 197
             ||| ||.|.:|  ||...:.|.....:.:....|:..|||::...|..::||.:|::|.:....
Zfish   963 IELLTLSDLRQK--KLDDTMALYTIFSETDACELWMGQKETWLVGLETPENLEDLEIVQNRLSIL 1025

  Fly   198 QKDMASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQR 262
            .::|.:.:.||..||:.|.:|....||:...:...:..||:.|:..|.:...::.::..|..:..
Zfish  1026 AQEMGNMQTRVDNVNKAAKQLEDSRHPQTKQVKDCQIRLNKRWEAFKAMVEDKKHRVDSALSLHN 1090

  Fly   263 FNRDADETVAWIAEKD-VVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLCS 326
            ::.|.|||.:||.||. |:.|:.|.|.|||:|..:|||..|:||||||::||:.:|..|||:|..
Zfish  1091 YDLDCDETESWIKEKTRVIESTQDLGNDLAAVITIQRKLFGMERDLAAIQDKLDSLRDEAQKLVK 1155

  Fly   327 IHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADE 391
            .|.:::..|..:|.|:...|.:|....::|:..|.|...|..||.|..|..:|:...:..:::::
Zfish  1156 EHPENASDILARQEELDAAWDTLKRTLKDREDSLGEVSKLQTFLQDMDDFQAWLFKSQKAVASED 1220

  Fly   392 LAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLERE----HYAAAEIQEKLAALENDK 452
            :...:..||.||..|...:.::|..|:.:....::|..:::.:    .|  .:::::|..|:...
Zfish  1221 MPDGLPEAEQLLNLHDALRHDMDGHEEDYHRVKDTGAAVIQGQEDDPQY--QQLEQRLEGLDKGW 1283

  Fly   453 SSLLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEK 517
            ..|..:|:.|:...:|.:..|.|.||.:|||..:..||..||:.|..|:||..|..:||||||..
Zfish  1284 GELHKMWDSRKNFLDQGLGFQQFMRDAKQADAILNNQEYTLAHVDKPDTLDGAEKALKKHEDFVT 1348

  Fly   518 SLAAQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFE 582
            ::.|.:|||.:......:|:|.::..:..|..:...:..|....|:|:.:....|:|:...|.|.
Zfish  1349 TMDANKEKILSTLETGQRLVDSENLYSGKVKDKMSSIEERNKKNQDKAKEVSGKLKDNRELQHFL 1413

  Fly   583 RDCDETKGWISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHY 647
            ::..:...||:||:..|.|.||.:..||:.|.||||.|..||.:||..:.:|...|.||:|.:..
Zfish  1414 QNTQDLTLWINEKMLTAQDTSYDEARNLHSKWQKHQAFMAELASNKDWLHNIDKEGQELMESKPE 1478

  Fly   648 AADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLS--EDHG 710
            ....:..|:.::..||:.|...:.:|...|.:|.:.:.|::::.|::.||:|::.||..  |:..
Zfish  1479 FEPIVKDRLAKLHELWDKLESTTQEKARLLFDANRSELFDQSLADLKKWLAELQQQLQGDVEEEV 1543

  Fly   711 KDLTSVQNLQKKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAP 775
            |||||...|.|||.:.|..|......:|.::.|..:. .|...|...:..::.||...:..|..|
Zfish  1544 KDLTSANILLKKHQITENQVRDRARELEELQEAVEQH-GSLREDQPELEIEQQNLQRDFQKLLTP 1607

  Fly   776 MGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHE 840
            :.:||..|..:..|.|.||||.||..|:.|:.|:|.|.:.|.:|..||.|:||:|::..||:.|:
Zfish  1608 LSQRKGKLEAAKAVHQFFRDLADEILWVNERLPMAMSDDHGNNLQTVQLLLKKNQSLQKEIDGHQ 1672

  Fly   841 ARLLNVISSGENMLKDQPFASDDIR--QRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADAN 903
            .|:..|:..|..|......:.::.|  :.::.||..|..|:|:.::|::.|..|.:|.||:.||:
Zfish  1673 PRIDEVLERGRRMAAAAEGSPEEERMSEEMKKLQVVWAQLQEEMAKRRERLYGSNEAQQYYNDAD 1737

  Fly   904 EAESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETPVVD 968
            ::|:|:.|:|......:..|||.|:..:||:|..|...::.:..:||.|.::|:....:|.|   
Zfish  1738 DSEAWIGEQELYMIADEMAKDEQSAMIMLKRHLVLKQTVDDYAYSIQQLADRAQKMLAEEHP--- 1799

  Fly   969 ITGKECVVALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLSA 1033
                                                                             
Zfish  1800 ----------------------------------------------------------------- 1799

  Fly  1034 SQQNLVDNHSIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQI 1098
                  |..:|.:||.|::.||..|..||.:|:.||:.|...::|.||..||.|||.:::..|. 
Zfish  1800 ------DGEAIIRRQGQVDKQYAGLKELAEDRKKKLDHTYHHFLLSREVEDLEQWIAERDVVAS- 1857

  Fly  1099 ADVVGEDLEEVEVLQKKFDDF-NDDLKANEVRLANMNEIAVQLTSLGQTEAALKIQTQMQDLNEK 1162
            :..:|:||:.|.:|:.||.:| .:.....:.|:..:|.|..:|...|.:|:|...:.: ..:||.
Zfish  1858 SQEMGQDLDHVTILRDKFREFARETGTVGQERVDTVNRIIDELIEGGHSESATLAEWK-DGVNES 1921

  Fly  1163 WNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVE 1227
            |.:|..|...:|..|.|::::.::..|..|....|.||.|.| .:|||:|....::..|.|...|
Zfish  1922 WADLLELIDTRAQLLTSSYDLLKYFYDGKELVGHIEEKKNEL-PEDLGEDFSKAESFHRMHAAFE 1985

  Fly  1228 RDLAALRDKIRQLDETANRL-MQSHPDTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQR 1291
            ||:::|..:::|..|||.|| .|...|.|....|.:||:.|.|..::.....|:::|.::.|..|
Zfish  1986 RDISSLGKQVKQFQETAARLHAQYAGDQATAIQATEKEVVEAWKGLLDACAGRRKQLEETADKFR 2050

  Fly  1292 FLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAASTSSIA 1356
            |.:..|||:||:.|::..:.:.|...||:..|.|::.||..||                      
Zfish  2051 FFTMVRDLMAWMESILQQIETQEKPRDVSSVELLMKYHQGIRA---------------------- 2093

  Fly  1357 SPSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQL 1421
                      ||:.|...|....|.|..||:..|..|.|||||:..|.:.|:::...|.:|...|
Zfish  2094 ----------EIETRGPKFNQCVQLGQALLERKHKDSAEIKEKLMQLVEKRKEMMLKWDDRWDWL 2148

  Fly  1422 EQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQT 1486
            ...|::..:.||..:||:|:.|:|.::.:.|.......||.|:|:||.|:|:....|::.:||:.
Zfish  2149 RLLLEVCQFARDASVAEAWLIAQEPYVASKDVGQTVDEVEKLLKRHEAFEKSTATWEERFSALER 2213

  Fly  1487 VADQLIAQNHYASNLVDEKRKQVLERWRHLKEGLIEKRSRL--GDEQTL------QQFSRDADEI 1543
            :....:.:.......:.:.|::..:..|....|..|:.|:|  .:||:|      :..|...|..
Zfish  2214 LTTLELLEIRKQQQEIQQYRQEAEKESRREDTGFAEESSQLYPTEEQSLSGLGVIEPSSGGVDGT 2278

  Fly  1544 ENWIAEKLQLATEESYK---DPA-NIQSKHQKHQAFEAELAANADRIQSVLAMGGNLIDKKQCSG 1604
            .......|....:||..   ||: :||...:..:|  |.|...:.::|.|| |.|.|..|.:..|
Zfish  2279 AGESTVPLISEMQESVSLELDPSTSIQVTKETEKA--ASLPTESTQVQPVL-MEGTLARKHELEG 2340

  Fly  1605 SEDAVQKR----------------------------------LTQIADQWEYLTHKTTEK---SL 1632
            .......|                                  ||......|.||:...:|   .|
Zfish  2341 PNKKAPNRSWNNLYCVLKPGHLSIYKDAKSFSHSVTFHGEEPLTLTNSSCEILTNYKKKKQVFKL 2405

  Fly  1633 KLKEANKQRTYIAAVKD---LDFWLGEVE 1658
            :|.:.::   |:...||   |..|...:|
Zfish  2406 RLGDGSE---YLFQCKDEEELQNWTQAIE 2431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 0/51 (0%)
SPEC 1074..1287 CDD:238103 65/214 (30%)
SPEC 1182..1425 CDD:238103 71/243 (29%)
SPEC 1426..1638 CDD:238103 57/260 (22%)
SPEC 1533..1744 CDD:238103 36/176 (20%)
SPEC 1646..1850 CDD:238103 5/16 (31%)
SPEC 1852..2062 CDD:238103
SPEC 1958..2176 CDD:238103
SPEC 2072..2296 CDD:238103
EFh 2311..2379 CDD:238008
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103 55/216 (25%)
SPEC 154..364 CDD:238103 66/210 (31%)
SPEC 261..470 CDD:238103 63/213 (30%)
SPEC 471..680 CDD:238103 67/208 (32%)
SPEC 682..893 CDD:238103 66/214 (31%)
Spectrin 893..>961 CDD:395348 21/67 (31%)
sptbXP_005158906.1 CH 182..285 CDD:237981
CH 306..409 CDD:237981
Spectrin 434..544 CDD:278843
Spectrin 554..656 CDD:278843
SPEC 662..873 CDD:238103 8/34 (24%)
SPEC 774..980 CDD:238103 41/148 (28%)
SPEC 982..1191 CDD:238103 65/208 (31%)
SPEC 1088..1299 CDD:238103 62/212 (29%)
SPEC 1303..1512 CDD:238103 67/208 (32%)
SPEC 1515..1723 CDD:238103 65/208 (31%)
SPEC 1622..1830 CDD:238103 71/281 (25%)
SPEC 1728..1940 CDD:238103 69/287 (24%)
SPEC 1941..2162 CDD:238103 74/253 (29%)
Spectrin 2156..>2210 CDD:278843 17/53 (32%)
PH 2326..2433 CDD:278594 22/110 (20%)
PH_beta_spectrin 2328..2433 CDD:269975 20/107 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.820

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