DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Spec and sptbn5

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:XP_021323109.1 Gene:sptbn5 / 569585 ZFINID:ZDB-GENE-131121-26 Length:4138 Species:Danio rerio


Alignment Length:3070 Identity:685/3070 - (22%)
Similarity:1204/3070 - (39%) Gaps:841/3070 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ENFTPKEVKILETVEDIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEK 66
            ||...|.::.|:  :..|:.:|||..|.|........|          ||| .|..|..||:.:.
Zfish   679 ENDIQKWIRTLQ--KQWQQLKEQVTIRKNRLHAANVIK----------QYF-ADITEASSWLDDH 730

  Fly    67 LQAASEESY-RDPTNLQAKIQKHQAFEAEVSAHSNAIVSL------------------------- 105
            .....:|.| :|..:..|.:|:||..|.|:.|:|:.:..|                         
Zfish   731 KPLLIDEDYGKDEASSTALLQRHQRVEKEMEAYSSEVKRLGEQAKSAAQLAPLTTETQQTRMVHY 795

  Fly   106 ---------------------------------------------------------------DN 107
                                                                           |:
Zfish   796 SDSSDGEDEKEKKADKGGKAVSKILQQEQAMIRFKYRGPKLIWDRGEILTIISREKDDKLLLRDS 860

  Fly   108 TGQEM-----------INQQ-----------------------------------------HFAS 120
            .|.|.           ::|:                                         ||..
Zfish   861 RGNEQLVSSTYIRELPVSQEAPPETTNGVAESPKRKVSRPRRTRSMRRGTAEISTSTLPDPHFQK 925

  Fly   121 ESIQVRLDELHKLWELLLSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLE 185
            ::|:...:.|.|.:..|.:....|...|:....|.:|...|||...|:.|||..:  :.|..:..
Zfish   926 DTIESTQNSLEKDFNRLYNLAQSKNKILEDTARLHRFYNACEEFESWMGDKENVL--NTFSSNSN 988

  Fly   186 HVEVLQRKFDEFQKDMASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVR 250
            ::||:|.|::.|..::||...::.::.:..|:|::..|..:..|.:|...:...|:|:::|....
Zfish   989 NLEVVQAKYENFVTELASGRKQLDDITKFGDELLKQQHSRKKDIQQRLGIVTRRWERIQKLKDEM 1053

  Fly   251 QEKLFGAHEIQRFNRDADETVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVS 315
            ..:|..:.:::.|.:...|..|.:..:...|.:.|.|...:::||.:.:....|||:.|||.|:.
Zfish  1054 AHELLSSADVKSFLQTCQEVQAQLQHRLAQLDTPDVGSSPSALQAEEHRQAQAERDIEALERKID 1118

  Fly   316 TLGAEAQRLCSIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWI 380
            .|.:.|:.........|..|.::...:.:..:.|..:|.:|::.|:|:..|..|..:.|||:.|.
Zfish  1119 YLKSVAKMKKDCSPAESAAIMEEVHALEDLLRQLKAQAIQRQRMLEEARRLQLFQKETRDLLMWA 1183

  Fly   381 NGMKAIISADELAKDVAGAEALLERHQEHKGEIDAREDSFK--------LTTESGQKLLEREHYA 437
            ...:..:..:|...|||.|:|||:.:.:.|.||:.::...|        |...||:|       .
Zfish  1184 EATQEHLLEEETGSDVASAQALLKENLDLKQEIELQKAKLKDMERLGQSLDVASGEK-------G 1241

  Fly   438 AAEIQEKLAALENDKSSLLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSL 502
            ..::|:.|..|:::.|.|..||..|....||.::.|....:.::.:..::..||.|...|||||:
Zfish  1242 GKDVQQTLTKLDHEWSQLDKLWSSRNRRLEQGLEFQKLNMEADRIEATISGHEARLKVRDLGDSV 1306

  Fly   503 DSVEALIKKHEDFEKSLAAQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSK 567
            |||.:|:.:.|:.|..|.|.|..|........:||..:::||.::.||.:::......|:|....
Zfish  1307 DSVHSLLSRQEELEALLEALERSIILFQDKCQELISKRNFAAKEIQQRSKVIQDHFKRLKESCKL 1371

  Fly   568 RRQLLEDSNRYQQFERDCDETKGWISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIE 632
            ||..|..|.:||:|.||.:|...|:.||.:.|.|:||.||||:..|::||:..|.|:.||..||:
Zfish  1372 RRLELLASKKYQEFLRDAEEMLLWMDEKFEIAEDESYRDPTNILRKLKKHEAAEKEMQANAVRID 1436

  Fly   633 DITNVGTELIEKQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWL 697
            .:...|.:::...||....|..:.||:...|..|.:...::|.||.:|.||:|....::|.:|.:
Zfish  1437 RLIETGEKMLADDHYNTQSIQKKTQEVHKRWIELQRKMAERGDKLRQAGQQEQLMELLQDAKLKI 1501

  Fly   698 SEIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKE 762
            ..||..|.:...|.||.|.:.|.|:|..||.:.....::|.|| |...|.:.:.|||:..|..:.
Zfish  1502 EAIERMLQNAIRGHDLRSSRQLLKEHKQLEEEAQELAEKINSI-VTRAKNLATNHFDSQRILKET 1565

  Fly   763 GNLSARYAALAAPMGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIK 827
            ......:.:|..|:..|:..|...:.:...:.|::.|..||.|.:|:|.:||..|.|:|..:|::
Zfish  1566 DTYLKLFKSLEKPLDHRRSQLEADVDLYSFYHDVDLELNWISEHQPVADTTNYERSLVGAVSLLQ 1630

  Fly   828 KHQAVLAEINNHEARLLNVISSGENMLKDQPFASDDIRQRLEALQEQW----------------- 875
            ||:.:.||:|.|...|..|:..|..|.:...:...:::||.|.|..:|                 
Zfish  1631 KHKDLQAEVNAHSKYLQRVLDRGRAMARSNQWNGQEVQQRCEQLIAKWEELEESCKKRSGELNRA 1695

  Fly   876 ----------------------------------------------------------------- 875
                                                                             
Zfish  1696 VTREQILLDCTELETLVSETSALVSTDYGKTELATRSLIKQHEGVEGQIEVLAAQVDELKSNVKQ 1760

  Fly   876 --------------NTLKEKSSQ-------RKQDLDDSLQAHQYFADANEAESWMREKEPIATGS 919
                          |.:|.|.|:       |:|.|.::|..|::..:.:|.|.|:.::..||..:
Zfish  1761 AVRVWGLEELNKPCNHIKSKLSELQHSATVREQRLRETLHLHEFKRETSELEEWIAQQTQIAASN 1825

  Fly   920 DYGKD------------------------------------------------------------ 924
            |.|.|                                                            
Zfish  1826 DLGSDYENAMQLRGRFEVFLKQLEVGKERMHTCEQLADKLIKSNHPESRFIRETQNLLRESWDEL 1890

  Fly   925 ---------------------EDSSEAL------------------------LKKHEALVSDLEA 944
                                 :|.::||                        |:||||||.:|..
Zfish  1891 QDLSKDRKEKLRKSEKCHKFYKDLTDALGQIKERHKTIPEDIAKDLKGVQSQLRKHEALVHELAG 1955

  Fly   945 FGNTIQAL-----------------------QEQAKN---------------------------- 958
            ....:|.|                       ||..:|                            
Zfish  1956 TEQQLQELLDGTDAILGMCSPELRVGLQELQQEVVENWERLRMRMEQREEELQSAKDRYMFLNTA 2020

  Fly   959 ------CRQ------QETPVVDITGKECVVALYDY----------TEKSPREVSMKKG------- 994
                  |.|      .|..:.|:.  .|.:.|:.:          .|...:.|||.:|       
Zfish  2021 QDYSLWCSQVLSWMKAEESIRDVA--TCDLQLFQHQQLWAEIVAREETFAQAVSMGQGLLENDIP 2083

  Fly   995 ------DVLTLLNSNNK---DWWKVEVNDRQGFVPAAYIKKI----------------------D 1028
                  :.|..|....:   |.|::    ||.::...|::::                      |
Zfish  2084 NAREIQEKLKALQEEREKLSDNWQL----RQKWLENTYLEQVFYRDTEYMEKITNSQEIQLKNSD 2144

  Fly  1029 AGLSASQQNLVDNHSIAKR----QNQINSQYDNLLA------------LARERQNKLNETVKAY- 1076
            .|.:..     |..|:.||    :..::||.|.::|            |.||:.:.:...:||. 
Zfish  2145 LGTTVD-----DVESLIKRHEAFEKLLHSQEDKMVALQESAERLKTEGLTREKNSNIKNKLKALQ 2204

  Fly  1077 ------------------------VLVREAADLAQWIRDKENHAQ-------------------- 1097
                                    :..|:.::..:||.|:.|..|                    
Zfish  2205 ERRERIKDLSGKRREDLEVSKLHCIFSRDVSEAEEWITDRMNKIQDDSKMDMSNLQTKMKMLQKH 2269

  Fly  1098 ----------------------------------------------------------------- 1097
                                                                             
Zfish  2270 QVFEAEILAHGNIIESVQQAGNELVTMHHPKSKEIRQTVSALISHWKALKQELAVRGKVLEDNRD 2334

  Fly  1098 -----------------------IADVVGEDLEEVEVLQKKFDDF----NDDLKANEVRLANMNE 1135
                                   :.| ||||.|..:.|.||..:|    :.|:..::..:..:|.
Zfish  2335 FLEFLQKVEQVEVWIRQKEVMINVGD-VGEDYEHGQQLLKKLSEFRGSGSGDVTVDDAHIKTINT 2398

  Fly  1136 IAVQLTSLGQTEAALKIQTQMQDLNEKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEK 1200
            :|.:|......| .:.::.:.|.|||:|.|.....:....:|.:|.||....|:::|.:|...||
Zfish  2399 LAARLERQNSDE-LVTVKKRRQQLNERWRNFHGNLSSYKRKLEAALEVHALIRELEEVRDRAGEK 2462

  Fly  1201 ANALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDKIRQLD-ETANRLMQSHPDTAEQTYAKQKE 1264
            ...|.....|.|:.||:.|.|:||.:||:...::::...|: ||.:|| :.|.|.:::...||:|
Zfish  2463 MLLLQGQGCGLDVESVENLIRRHEEMEREARVIQERGAALEKETKDRL-KRHCDLSDKLSKKQEE 2526

  Fly  1265 INEMWDQIITKSTARKEKLLDSYDLQRFLSDYRDLLAWINSMMSLVTSDE-----LANDVTGAEA 1324
            :.....::..:...|||:|.:|:.||.|.::.|.||.|     :|..|||     |..:.|.||:
Zfish  2527 VKIALVKLDKEIKRRKERLQESHQLQLFKANQRLLLDW-----TLKQSDEMVKKGLPKNKTEAES 2586

  Fly  1325 LIERHQARRAEIGFTLGISSAPGAAASTSSIASPSGDEEHRTEIDARAGTFGAFEQFGNELLQAN 1389
            .|..|                                .:.:.|||||.....:.:.||..|:::.
Zfish  2587 FILEH--------------------------------HDWKAEIDARGDRIDSVKSFGQNLVKSG 2619

  Fly  1390 HYASPEIKEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDDA 1454
            |..:.||||.:..|..|:..|.:||.:||..|:|.|.||:::...:..|||||.|||||..:|..
Zfish  2620 HSDAAEIKEALRKLDDAKTMLTRAWEDRRKTLDQALKLQIFLGYADQTESWMSNREAFLINEDLG 2684

  Fly  1455 NAGGNVEALIKKHEDFDKAINGHEQKIAALQTVADQLIAQNHYASNLVDEKRKQVLERWRHLKEG 1519
            .:...||||.:|...|:.::....::::.:...|.|||..|||.|:.:.::.|.:|.|    ||.
Zfish  2685 GSLSEVEALQRKLALFENSLEAQMEQVSEVDRYAQQLIQANHYDSDNIKKRTKAILLR----KER 2745

  Fly  1520 LIE----KRSRLGDEQTLQQFSRDADEIENWIAEKLQLATEESYKDPANIQSKHQKHQAFEAELA 1580
            ::|    :|..|.:...||:|...:.||.:|:.||..:|.:||:|||.|:|:|..|||:||||:.
Zfish  2746 ILEISKSRRKALEESLQLQKFLEASYEISSWLNEKNSVAVDESWKDPINLQAKLLKHQSFEAEIL 2810

  Fly  1581 ANADRIQSVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIA 1645
            ||.:|:|:.:..|.|::.....:.|:  ::.|:..:.|.|:.|......|..:|::|.:...:..
Zfish  2811 ANRNRVQAHIKDGDNMLAFSHPAKSK--IKPRIKDVDDNWDQLLSNCKHKKTRLQQAYQALQFQR 2873

  Fly  1646 AVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKKHQLVEADIVAHEDRIKDMNNQADSLVESGQF 1710
            ::.|::.|||.||..:..:|.|.|||||..|:|..|.:|..:.||.::::.:.:.|......|.|
Zfish  2874 SLGDIEEWLGSVEVEVANDDYGGDLASVSRLLKALQGLEEMVDAHMEKVQGLVDTAKDFSSQGNF 2938

  Fly  1711 DTAGIQEKRQSINERYERICNLAAHRQARLNEALTLHQFFRDIADEESWIKEKKLLVGSDDYGRD 1775
            ....||::...:..||..:......|:..|.....|.||:||:.||..||::|.....:.|:|..
Zfish  2939 LADNIQQRVWEVVNRYNGLAEPMQTRRETLESWQLLFQFYRDLEDELLWIEDKLQATATKDWGTS 3003

  Fly  1776 LTGVQNLKKKHKRLEAELGSHEPAIQAVQEAGEKLMDVSNLGVPEIEQRLKALNQAWAELKNLAA 1840
            |..:|::.|||..:..|:.:..|.|.||||||:.|:...:....||.::|..|.:.:..||..:|
Zfish  3004 LQSIQSIVKKHLVVMQEIENRTPLIMAVQEAGQNLVRGRHFASREISEKLSGLKKNFDALKKESA 3068

  Fly  1841 TRGQKLDESLTYQQFLAQVEEEEAWITEKQQLLSVEDYGDSMAAVQGLLKKHDAFETDFTAHKDR 1905
            .:.:.|.::|..|.||::|.:.|.|:.|::.:|...|||.:..|.:..|:|.|..:.:..:.:.:
Zfish  3069 NKDRLLQQALKIQSFLSEVSQLEQWMEEQKPVLESRDYGKNEEATEAFLRKLDTVDLELESQRGK 3133

  Fly  1906 CSLICDQGSELVEAKNHHGESIAQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFMWKADVVES 1970
            ...:...|::|.::::.:...:::..:.::.:.:.|..|:..|:..|.:...:..|...|..:::
Zfish  3134 VEALLKTGTDLEKSQHPNSHLVSKSLEDMQGEFETLLQLSGERRTELENQYNFYIFERDARDLQT 3198

  Fly  1971 WIDDKENYVRSDEFGRDLSTVQTLLTKQETFDAGLNAFEQEGIHNITALKDQLINASHAQSPAIL 2035
            |:..::....||::|:||..|:.|..|.|.|...:....|..:..:..|| |.:.::.||     
Zfish  3199 WLLSRKTIAESDDYGKDLEGVEALQKKFEDFSEEVGTLGQSKLSTVQKLK-QSVQSADAQ----- 3257

  Fly  2036 KRHGDVIARWQKLRDASNTRKDRLLAMQE--QF-RQIEELYLTFAKKASAFNSWFENAEEDLTDP 2097
            ::..|::..|:.|..|...|.:.|.:.:|  || ..::||.:...:|..|.:|      |:|.  
Zfish  3258 QKEKDLLKLWEDLNKAMKARAENLHSAREVHQFEHDLDELRIWMNEKEVALDS------EELK-- 3314

  Fly  2098 VRCNSIEEIRALRDAHAQFQASLSSAEADF-------KALAALDQKIK-SFNVGPNPYTWFTMEA 2154
               |.:..::||...|...:..|:..|.|.       |||.....::: |.:.        .::.
Zfish  3315 ---NDLLSVQALIRQHEGLERDLAVIEEDVSRRKEEGKALVRRSPRVRDSLSK--------RLQE 3368

  Fly  2155 LEETWRNLQKIIEERDGELAKEAKRQEENDKLRKEFAKHANLFHQWLTETRYYMLGYNRQGTSMM 2219
            :||.||||.                  |....|::..:.|....::|.|.| .|:|:.::..|:|
Zfish  3369 VEEIWRNLL------------------EKANQRRQRLQQAEAVQRYLIEWR-EMMGWLKETLSLM 3414

  Fly  2220 --EGSGSLEQQLEALRVKATEVRAR-----------RVDLKKIEELGAL----LEEHLI----LD 2263
              ||.|...:.||.:..|..|.|.:           :.|.:::.|.|..    |||.|.    |:
Zfish  3415 TGEGFGGKVKDLEQMIKKHDEYRTQIDRQLDKSEMVKNDGRRLMEEGNSWSHELEERLAELKDLE 3479

  Fly  2264 NRYTEHSTVGLAQQWDQLDQLSMRMQHNLEQQIQARNHSGVSEDSLKEFSMMFKHFDKDKSGKLN 2328
            .|..|..|...||..:.::  ..::|..|||.                     :|:       ||
Zfish  3480 VRVLEAWTERRAQYQEDIE--LQQLQRELEQA---------------------EHW-------LN 3514

  Fly  2329 HQEFKSCLRALGYDLPMVEEGQPDPEFEAILDVVDPNRDGYVSLQEYIAFMISKETENVQSYE-- 2391
              .::|.|||..|.             |::.||:|     .:..||.:..||..::|...:.:  
Zfish  3515 --TYESALRAEDYG-------------ESVSDVLD-----LMKKQEDLEAMIQAQSERFNALQAR 3559

  Fly  2392 --EIENAFRAITAAD 2404
              :.||..:.|...|
Zfish  3560 RTQRENKMKEIQRGD 3574

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 14/77 (18%)
SPEC 1074..1287 CDD:238103 63/350 (18%)
SPEC 1182..1425 CDD:238103 72/248 (29%)
SPEC 1426..1638 CDD:238103 72/215 (33%)
SPEC 1533..1744 CDD:238103 66/210 (31%)
SPEC 1646..1850 CDD:238103 63/203 (31%)
SPEC 1852..2062 CDD:238103 46/209 (22%)
SPEC 1958..2176 CDD:238103 52/228 (23%)
SPEC 2072..2296 CDD:238103 58/252 (23%)
EFh 2311..2379 CDD:238008 14/67 (21%)
EFhand_Ca_insen 2386..2456 CDD:400872 4/23 (17%)
SPEC 48..258 CDD:238103 57/350 (16%)
SPEC 154..364 CDD:238103 50/209 (24%)
SPEC 261..470 CDD:238103 56/216 (26%)
SPEC 471..680 CDD:238103 68/208 (33%)
SPEC 682..893 CDD:238103 65/313 (21%)
Spectrin 893..>961 CDD:395348 27/229 (12%)
sptbn5XP_021323109.1 SAC6 24..>387 CDD:227401
SPEC 394..605 CDD:238103
SPEC 606..>776 CDD:238103 30/109 (28%)
SPEC 958..1167 CDD:238103 50/210 (24%)
SPEC 1066..1272 CDD:238103 54/212 (25%)
SPEC 1275..1484 CDD:238103 68/208 (33%)
SPEC 1381..1588 CDD:238103 68/207 (33%)
SPEC 1591..1799 CDD:238103 35/207 (17%)
SPEC 1800..2010 CDD:238103 25/209 (12%)
SPEC 2014..2222 CDD:238103 33/218 (15%)
SPEC 2120..2331 CDD:238103 21/215 (10%)
SPEC 2230..2443 CDD:238103 28/214 (13%)
SPEC 2444..2655 CDD:238103 72/248 (29%)
SPEC 2656..2866 CDD:238103 72/215 (33%)
SPEC 2870..2969 CDD:197544 27/98 (28%)
SPEC 2973..3184 CDD:238103 57/210 (27%)
SPEC 3189..3390 CDD:238103 54/243 (22%)
SPEC 3394..>3559 CDD:238103 49/215 (23%)
Atrophin-1 <3557..3901 CDD:331285 4/18 (22%)
PH-like 3919..4019 CDD:327399
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

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