DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Spec and actn1

DIOPT Version :9

Sequence 1:	NP_001261286.1	Gene:	alpha-Spec / 38231	FlyBaseID:	FBgn0250789	Length:	2457	Species:	Drosophila melanogaster
Sequence 2:	XP_005157053.1	Gene:	actn1 / 560400	ZFINID:	ZDB-GENE-081113-4	Length:	924	Species:	Danio rerio

Alignment Length:	917	Identity:	231/917 - (25%)
Similarity:	392/917 - (42%)	Gaps:	255/917 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1630 KSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKKH--QLVEADIVAHED 1692
            |:...|..|.|..:|:       |              ||......|:.:|  :|::.:.:..:|
Zfish   167 KTAPYKNVNIQNFHIS-------W--------------KDGLGFCALIHRHRPELIDYNKLRKDD 210

  Fly  1693 RIKDMNN---------------QADSLVESGQFDT--------------AGIQEKRQSINERYER 1728
            .:.::|.               .|:.:|.:.:.|.              :|.|:...:.|    |
Zfish   211 PMTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAAN----R 271

  Fly  1729 ICNLAAHRQARLNEALTLHQFFRDIADEESWIK------------------EKKLLVGSDDYGRD 1775
            ||.:.|..|.  ||.| :..:.:..:|...||:                  ::||    :|: ||
Zfish   272 ICKVLAVNQE--NEQL-MEDYEKLASDLLEWIRRTIPWLENRVPENTMQAMQQKL----EDF-RD 328

  Fly  1776 LTGVQNLKKKHKRLEAELG----------SHEPAIQAVQEAGEKLMDVSNLGVPEIEQRLKALNQ 1830
            ...:....|..::.:.|:.          |:.||.  :...|:.:.|:||..     .||:...:
Zfish   329 YRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAF--MPSEGKMVSDISNSW-----GRLEGAEK 386

  Fly  1831 AWAELKNLAATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLLSVEDYGD-SMAAVQGLLKKHDA 1894
            .:.|.......|.::||.  ..::|..:....|||...|:::|..:|:.. |::.::.|||||:|
Zfish   387 GYEEWLLNEIRRLERLDH--LAEKFRQKAAIHEAWTDGKEEMLQHKDFETASLSEIKALLKKHEA 449

  Fly  1895 FETDFTAHKDRCSLICDQGSELVEAKNHHGESIAQRCQQLRLKLDNLSALAARRKGALLDNSAYL 1959
            ||:|..||:||...|.....||.|.:.:...|:..|||::..:.|:|..|..:|..||
Zfish   450 FESDLAAHQDRVEQIAAIAQELNELEYYDSPSVNARCQRICDQWDSLGVLTQKRSEAL------- 507

  Fly  1960 QFMWKADVVESWIDDKENYVRSDEFGRDLSTVQTLLTKQETFDAGLNAFEQEGIHNITALKDQLI 2024

Zfish   508 ----------------------------------------------------------------- 507

  Fly  2025 NASHAQSPAILKRHGDVIARWQKLRDASNTRKDRLLAMQEQFRQIEELYLTFAKKASAFNSWFEN 2089
                                         .|.::||      ..|::|||.|||:|:.||:|.|.
Zfish   508 -----------------------------QRTEKLL------ETIDQLYLEFAKRAAPFNNWMEG 537

  Fly  2090 AEEDLTDPVRCNSIEEIRALRDAHAQFQASLSSAEADFKALAALDQKI----KSFNV---GPNPY 2147
            |.|||.|....::||||:.|..||.||:|:|..|:.:.:|:..:..:|    ::::|   |.|||
Zfish   538 AMEDLQDTFIVHTIEEIQGLSTAHEQFKATLPEADKERQAILGIHNEIAKIVQTYHVNMAGQNPY 602

  Fly  2148 TWFTMEALEETWRNLQKIIEERDGELAKEAKRQEENDKLRKEFAKHANLFHQWLTETRYYMLGYN 2212
            |....:.:...|..:::::.:||..|.:|..||:.|::||::||..||:...|: :|:...:
Zfish   603 TTINPQEINAKWDKVRQLVPQRDQALIEEHARQQNNERLRRQFANQANVIGPWI-QTKMEEI--- 663

  Fly  2213 RQGTSMMEGSGSLEQQLEALRVKATEVRARRVDLKKIEELGALLEEHLILDNRYT----EHSTVG 2273
              |...:|..|:||.||..||.....:...:..:.::|....|::|.||.||::|    ||..||
Zfish   664 --GRISIEMHGTLEDQLTHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVG 726

  Fly  2274 LAQQWDQLDQLSMRMQHNLEQQIQARNHSGVSEDSLKEFSMMFKHFDKDKSGKLNHQEFKSCLRA 2338
                |:||.....|..:.:|.||..|:..|:|::.:.||...|.|||:|.||.|..:|||:||.:
Zfish   727 ----WEQLLTTIARTINEIENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGAEEFKACLIS 787

  Fly  2339 LGYDLP------------------MVEEG--QPDPEFEAILDVVDPNRDGYVSLQEYIAFMISKE 2383
            ||:|:.                  ::..|  ..:.||..|:.:|||||.|.|:.|.:|.|| |:|
Zfish   788 LGFDIGNDAQKRTGMMDAEDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFM-SRE 851

  Fly  2384 TENVQSYEEIENAFRAITAADRPYVTKEELYCNLTKDMADYCVQRMKPFSEPRSGQPIKDALDYI 2448
            |.:..:.:::..:|: :.|.|:.|:..:||...|..|.|:||:.||.|:|.|.|   :..||||:
Zfish   852 TADTDTADQVMASFK-VLAGDKNYILADELRRELPPDQAEYCIARMTPYSGPDS---VPGALDYM 912

  Fly  2449 DFTRTLF 2455
            .|:..|:
Zfish   913 SFSTALY 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Spec	NP_001261286.1	SH3_Alpha_Spectrin	974..1026	CDD:212742
		SPEC	1074..1287	CDD:238103
		SPEC	1182..1425	CDD:238103
		SPEC	1426..1638	CDD:238103	2/7 (29%)
		SPEC	1533..1744	CDD:238103	26/144 (18%)
		SPEC	1646..1850	CDD:238103	45/262 (17%)
		SPEC	1852..2062	CDD:238103	38/210 (18%)
		SPEC	1958..2176	CDD:238103	44/224 (20%)
		SPEC	2072..2296	CDD:238103	78/234 (33%)
		EFh	2311..2379	CDD:238008	31/87 (36%)
		EFhand_Ca_insen	2386..2456	CDD:400872	23/70 (33%)
		SPEC	48..258	CDD:238103
		SPEC	154..364	CDD:238103
		SPEC	261..470	CDD:238103
		SPEC	471..680	CDD:238103
		SPEC	682..893	CDD:238103
		Spectrin	893..>961	CDD:395348
actn1	XP_005157053.1	CH	42..140	CDD:278723
		CH	155..259	CDD:237981	16/112 (14%)
		Spectrin	284..394	CDD:278843	21/122 (17%)
		SPEC	405..632	CDD:238103	79/333 (24%)
		Spectrin	640..743	CDD:278843	33/112 (29%)
		EFh	760..849	CDD:238008	33/89 (37%)
		EF-hand_7	762..848	CDD:290234	29/85 (34%)
		EFhand_Ca_insen	854..920	CDD:285885	23/70 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920