DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Spec and LOC558044

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_001093459.1 Gene:LOC558044 / 558044 -ID:- Length:2391 Species:Danio rerio


Alignment Length:1736 Identity:480/1736 - (27%)
Similarity:824/1736 - (47%) Gaps:235/1736 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 DIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKL-QAASEESYRDPTN 80
            ::.||.:.|.::::..:..::.:.:.|.:|..|..|:.||:::|:||.|.| |.:|:|...|..:
Zfish   753 EVTERIKDVRAQWSHLEEASQLREQSLNESVAFHQFQTDANDMEAWILETLRQVSSQEVGHDEFS 817

  Fly    81 LQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWELLLSRLAEKG 145
            .|...:|.:..|.|:.:|.:.|.||...| .::.:.:..|..::.||..:.:.:|.|....:...
Zfish   818 TQTLARKQREVEEEIQSHRSLIDSLHEQG-SLLPEAYAHSPQVEGRLPAIEQRYEELEGLSSSWR 881

  Fly   146 LKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQKDMASQEYRVTE 210
            ..|..||.|.:...:......|:.:||.::...|....||.:||:|::||..:.:|.:...|:::
Zfish   882 QALDGALALYRMFSEASACQLWVGEKEQWLHNMEIPTKLEDLEVIQQRFDTLEPEMNTLGGRISD 946

  Fly   211 VNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNRDADETVAWIA 275
            |||:|.:|:...:..:|.|.:.:.:||..|...:.||..|::.|..|..||.::.:.:|..:|:.
Zfish   947 VNQVAQQLLGSDNRNKDQIDQTQNQLNNRWSDFQSLANQRKQALESALNIQNYHLECNEIKSWMK 1011

  Fly   276 EK-DVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLCSIHADHSDQIRDKQ 339
            || .|:.|:...|.|||.|.|||||..|:||||.|::.|:..|.:||::|.|.|.:..::|:.:.
Zfish  1012 EKTKVIESTQSLGNDLAGVMALQRKLTGMERDLEAIQGKLDDLRSEAKKLVSEHPEQEEEIKGQL 1076

  Fly   340 AEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELAKDVAGAEALLE 404
            |||...|:.|....:.|::.|.|:..|..||.|..|..:|::..:..:::::....:|.||.||.
Zfish  1077 AEIQEVWEELRATMKRREESLGEASKLQGFLRDLDDFQAWLSRTQTTVASEDTPTSLAEAERLLA 1141

  Fly   405 RHQEHKGEIDAREDSFKLTTESG----QKLLEREHYAAAEIQEKLAALENDKSSLLSLWEDRRIL 465
            :|:..|.|:|..::.::....:|    |...:.:|...|   ::|.||:.....|..:||.|..:
Zfish  1142 QHEAIKNEVDNYKEDYEKMRATGAEVTQGQTDAQHMFLA---QRLQALDTGWHELRRMWESRHCV 1203

  Fly   466 YEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIKALD 530
            ..|..|.|...||.:||:.::..||..|::.::..||...|..|||||||..::.|.||||..:.
Zfish  1204 LAQAFDFQTLLRDAKQAEGFLNSQEYVLSHTEMPSSLQGAEEAIKKHEDFLTTMEASEEKINGVV 1268

  Fly   531 IFATKLI-DGQHYAADDVAQRRQMLLARRAALQEKSSKRRQL-------LEDSNRYQQFERDCDE 587
            ....:|: ||..| ||.:.::..       ::||:..|.:|.       |:|:...|.|.:|..|
Zfish  1269 ESGRRLVSDGNTY-ADKIQEKTD-------SIQERHQKNKQAANELLAKLKDNRELQHFLQDGQE 1325

  Fly   588 TKGWISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAADQI 652
            ...||:||:..|.|.||.:..||:.|.||||.|..||.:||..::.|...|..|::::......:
Zfish  1326 LTLWINEKMLTAQDMSYDEARNLHSKWQKHQAFMAELASNKDWLDKIDKEGQVLVKEKPELEQTV 1390

  Fly   653 NTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQ 717
            :..:..:...|..|...:..|...|.:|.:.:.|.::...::.||..|..||.|:|.|||||||.
Zfish  1391 SETLSGLQKQWVELENTTQAKAQCLFDANRAELFTQSCSALDSWLQNISSQLQSDDFGKDLTSVN 1455

  Fly   718 NLQKKHALLEADVMAHQDRIESIKVAANKFI--ESGHFDADNIRNKEGNLSARYAALAAPMGERK 780
            .|.|||.:||..:...:..::|::..|....  :||..:.|   .::..::.|::.|..|:.||:
Zfish  1456 ILLKKHQMLEHQMDVREKEVQSLQSQALALAQEDSGIVEVD---GEQRRVTDRFSQLQDPLKERR 1517

  Fly   781 QHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLN 845
            ||||.|.:..|..||||||..|::|:.|:|.||:.|:||..||.|:||:|.:..||..|:.|:.:
Zfish  1518 QHLLASKEAHQFNRDLEDEILWVKERMPLATSTDHGKDLPSVQLLMKKNQTLQKEIQGHQPRIDD 1582

  Fly   846 VISSGENMLKDQPFASDDIRQ-----RLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEA 905
            :.:.|.||...:....|..|:     ||..|:|.|..|..::.||...|.::.:|.|::.||.||
Zfish  1583 IQAHGTNMSPGKESEMDRERRAALDGRLAELRELWALLISETEQRNVRLAEANRAQQFYTDAAEA 1647

  Fly   906 ESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETPVVDIT 970
            |:||.|:|......:..|||.|:..::|||:.|...||.:..||..|...::.....|.|     
Zfish  1648 EAWMGEQELHMMSEEKAKDEQSALVMVKKHQILEQALEDYAQTIHQLANSSRLMVNSEHP----- 1707

  Fly   971 GKECVVALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLSASQ 1035
                                                                             
Zfish  1708 ----------------------------------------------------------------- 1707

  Fly  1036 QNLVDNHSIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKE----NHA 1096
                ::..|..||.|::..|..|..||.||:.||.|.::...|.||..||.|||.::|    :|.
Zfish  1708 ----ESERITLRQAQVDKLYAGLKDLAEERRGKLQERLRLTQLKREVDDLEQWIAEREVVAGSHE 1768

  Fly  1097 QIADVVGEDLEEVEVLQKKFDDF-NDDLKANEVRLANMNEIAVQLTSLGQTEAALKIQTQMQDLN 1160
                 :|:|.|.|.:|:.||.:| .|.....:.|:..:|..|.:|...|..|.| .:......||
Zfish  1769 -----LGQDYEHVTMLRDKFREFARDTSTIGQERVDAVNAQADELIESGHPENA-SVAEWKDGLN 1827

  Fly  1161 EKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEG 1225
            |.|.:|..|...:...|.:::|:.|||:|..|....|.||...|...:||:||.:||...|:|..
Zfish  1828 EAWADLLELIDTRTQMLAASYELHRFHQDAREALGLIREKKETLAGAELGRDLNTVQHFLRQHTA 1892

  Fly  1226 VERDLAALRDKIRQLDETANRLMQSHP-DTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDL 1289
            .|.|:.||..::.|:.:.|.||.:::. :.|:..:..::.:.|.|:.:.:.:..|:..|||:.:.
Zfish  1893 YEHDVQALSGQVTQVQDDAARLQKAYAGEKADDIHRHERAVTEAWEGLQSATQTRRLLLLDTVEK 1957

  Fly  1290 QRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAASTSS 1354
            .|||:..|||:.|:..:...:.|.:...||:.|..:|..||                        
Zfish  1958 FRFLNMVRDLMLWMEGINLQIQSHDSPRDVSSAGLVIANHQ------------------------ 1998

  Fly  1355 IASPSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRL 1419
                    :.::||:.||.:|.|..:.|..|:..|||||.||:||::.|...|.::.:.|.|:..
Zfish  1999 --------DIKSEIETRADSFTACSEMGRTLINNNHYASDEIQEKLDQLQAKRTEINQKWQEKMD 2055

  Fly  1420 QLEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGN---VEALIKKHEDFDKAINGHEQKI 1481
            .|:..|::..:.||..:||||::.:|..:.|   |..|.|   ||:|||:||.|:|...|.|.:.
Zfish  2056 HLQIVLEVLQFGRDASMAESWLAGQEPLVRA---AELGSNVDEVESLIKRHEAFEKLAAGWEDRF 2117

  Fly  1482 AALQ---TVADQLIAQNHYASNLVDEKRKQVLERWRH----------LKEGLIEKRSRLG-DEQT 1532
            :.|:   |:.:|.|           ::|::..||.|.          ::..:.:..:|.. |:.|
Zfish  2118 SQLEKLTTLEEQEI-----------QRRREEEERARRPPTPPPVEEVVQSEINDSAARTSLDQTT 2171

  Fly  1533 LQQ-------FSRDADEIENWIAEKLQLATEESYKDPANIQSKHQ-------------------- 1570
            |.|       :| |.|..:...:|.:.....:|..|.|:.|....                    
Zfish  2172 LNQSVSVNGVYS-DQDTSQGSESESVNGPGRDSGLDSASRQDPSATLPGRGGAEGTTEAMEGILC 2235

  Fly  1571 KHQAFEAELAANADR----IQSVLAMG--GNLIDKKQCSGS-------EDAVQKRLTQIADQWEY 1622
            :.|..|:....:|:|    :..||..|  |...|.|..|..       ..::.:.:.::|..::.
Zfish  2236 RKQEMESHNKKSANRSWQNVYCVLRKGSLGFYKDNKSASNGIPYHGEVPISLGEAVCEVAHDYKK 2300

  Fly  1623 LTHKTTEKSLKLKEANKQRTYIAAVKD---LDFWLGEVESLLTTED 1665
            ..|..   .|:|.:.   :.|:...||   :..|:..::|.:::.:
Zfish  2301 RKHVF---KLRLGDG---KEYLFQAKDEAEMSSWIRAIQSSMSSSE 2340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 0/51 (0%)
SPEC 1074..1287 CDD:238103 66/218 (30%)
SPEC 1182..1425 CDD:238103 69/243 (28%)
SPEC 1426..1638 CDD:238103 58/268 (22%)
SPEC 1533..1744 CDD:238103 30/176 (17%)
SPEC 1646..1850 CDD:238103 4/23 (17%)
SPEC 1852..2062 CDD:238103
SPEC 1958..2176 CDD:238103
SPEC 2072..2296 CDD:238103
EFh 2311..2379 CDD:238008
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103 58/210 (28%)
SPEC 154..364 CDD:238103 69/210 (33%)
SPEC 261..470 CDD:238103 66/213 (31%)
SPEC 471..680 CDD:238103 67/216 (31%)
SPEC 682..893 CDD:238103 76/217 (35%)
Spectrin 893..>961 CDD:395348 24/67 (36%)
LOC558044NP_001093459.1 CH 94..197 CDD:237981
CH 213..316 CDD:237981
Spectrin 341..451 CDD:278843
SPEC 465..563 CDD:197544
SPEC 568..782 CDD:238103 4/28 (14%)
SPEC 681..888 CDD:238103 33/135 (24%)
SPEC 785..994 CDD:238103 58/209 (28%)
SPEC 997..1201 CDD:238103 64/206 (31%)
SPEC 1209..1419 CDD:238103 67/217 (31%)
SPEC 1420..1635 CDD:238103 76/217 (35%)
SPEC 1636..1848 CDD:238103 72/291 (25%)
SPEC 1849..2058 CDD:238103 68/240 (28%)
SPEC 2065..>2123 CDD:197544 23/60 (38%)
PH_beta_spectrin 2230..2333 CDD:269975 19/108 (18%)
PH 2230..2333 CDD:278594 19/108 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.820

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