DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Spec and sptbn1

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:XP_009304586.2 Gene:sptbn1 / 553451 ZFINID:ZDB-GENE-031006-3 Length:2363 Species:Danio rerio


Alignment Length:1781 Identity:499/1781 - (28%)
Similarity:847/1781 - (47%) Gaps:218/1781 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 EVKILETVEDIQER---REQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQA 69
            |.||.|.:.|:|.:   .||:.|          .::.:||::.....|:.|||::::|..:.|:.
Zfish   724 EAKIRERIADVQAQWAALEQLAS----------VRKTRLEEACSLHQFQADADDVDTWTLDALRI 778

  Fly    70 ASEESY-RDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKL 133
            .|.... .|..:.||.::||:....||:::...|.:|....|.:..:| ..|.::..||..:.:.
Zfish   779 VSTADVGHDEFSTQALVKKHKDASTEVASYRPVIDALHEQAQTLPPEQ-ANSANVSERLAGIEER 842

  Fly   134 WELL--LSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDE 196
            ::.:  |:||.::.  ||.||.|.:...:.:....||.:||.::.:.|..:.||.:||:|.:|:.
Zfish   843 YKEVSELTRLRKQA--LQDALALYKMFSEADACELWIDEKEQWLNSMEIPEKLEDLEVIQHRFES 905

  Fly   197 FQKDMASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQ 261
            .:.:|.:|..||..|||:|.:|:..|||....|..::::||..|.:.:.|...::|.|..|..:|
Zfish   906 LEPEMNNQASRVAVVNQIARQLIHSGHPSEKDIKAQQDKLNTRWSQFRDLVDQKKESLNSALGVQ 970

  Fly   262 RFNRDADETVAWIAEK-DVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLC 325
            .::.|.:||.:||.|| .|:.|:.:.|.||..|.|||||..|:||||||:|.|:..|..||.||.
Zfish   971 NYHLDCNETKSWIREKTKVIESTQELGNDLTGVMALQRKLTGMERDLAAIEAKLGDLRGEADRLA 1035

  Fly   326 SIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISAD 390
            ..|.|.:..|..:.|||...|:.:....|.|::.|.|:..|.:||.:..|..||::..:..|:::
Zfish  1036 GEHPDQAKAITGRLAEITAVWEEMKETLRTREESLGEASKLQQFLRELDDFQSWLSRTQTAIASE 1100

  Fly   391 ELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREHYAA-AEIQEKLAALENDKSS 454
            ::...:|.||.||.:|:..|.||:..|:.::...:.|:.:.:.:..|. ..::::|.||:...:.
Zfish  1101 DMPNTLAEAEKLLAQHEGIKNEINNYEEDYQKMRDMGEMVTQDQTDAQYMFLRQRLQALDTGWNE 1165

  Fly   455 LLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSL 519
            |..:||:|:.|..|....|:|.|||:||:.::..||..||:.::..:|:..||.|||.|||..::
Zfish  1166 LHKMWENRQNLLSQSHAYQIFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTM 1230

  Fly   520 AAQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQL-------LEDSNR 577
            .|.|:||..:.....:|....:..||.:.:       |.|::.::..|.|:.       |:|:..
Zfish  1231 DANEDKINGVVEAGRRLASDGNINADRIQE-------RAASIDDRHKKNREAAVELLMRLKDNRD 1288

  Fly   578 YQQFERDCDETKGWISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELI 642
            .|:|.:||.|...||:||:..|.|.||.:..||:.|..|||.|..||.:||..::.|...|.:|:
Zfish  1289 LQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELQSNKEWLDKIEKEGKQLV 1353

  Fly   643 EKQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSE 707
            .::......:..::..:..:|..|...:..|...|.:|.:.:.|.::..|::.||..:|||:.|:
Zfish  1354 SEKPETEAVVKEKLAALQKMWTELETTTQTKAQCLFDANKAELFTQSCADLDKWLVGLEGQIQSD 1418

  Fly   708 DHGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNLSARYAAL 772
            |:|||||||..|.||..:||..|...|..:|.::..|:...:.|. |.|.:..:...:..::..|
Zfish  1419 DYGKDLTSVNILLKKQQMLENQVEVRQREVEELQSQAHVLRQEGK-DTDEVDGRRKVVEQKFQEL 1482

  Fly   773 AAPMGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEIN 837
            ..|:.:||..|:.|.::.|..||:|||..|:.|:.|:|.||:.|.:|..||.||||:|.:..||.
Zfish  1483 LDPLLKRKNFLMASREIHQFNRDVEDEILWVEERMPLATSTDHGNNLQTVQLLIKKNQTLQKEIQ 1547

  Fly   838 NHEARLLNVISSGENMLK-DQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFAD 901
            .|:.|..::....:::|| |.|.. :.||.||..||..|:.:.:::.:|...|:::.:|.||:.|
Zfish  1548 GHQPRCDDIFERSQSILKADSPNV-EGIRTRLSDLQGLWSLIMQETEKRHSRLEEAHKAQQYYFD 1611

  Fly   902 ANEAESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETPV 966
            |.|||:||.|:|......:..|||.||.|:||||:.|...:|.:..|:..|              
Zfish  1612 AAEAEAWMSEQELYMMSEEKAKDEQSSVAMLKKHQILEQAVEDYAETVHQL-------------- 1662

  Fly   967 VDITGKECVVALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGL 1031
                                                                      .|...||
Zfish  1663 ----------------------------------------------------------SKTSRGL 1669

  Fly  1032 SASQQNLVDNHSIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKE--- 1093
            .|:  |..::..|..||:|::..|..|..|:.||:.||.|..:.:.|.||..||.|||.::|   
Zfish  1670 VAA--NHPESERIGMRQSQVDKLYAGLKDLSEERRGKLEERFRLFQLNREVDDLEQWIAEREVVA 1732

  Fly  1094 -NHAQIADVVGEDLEEVEVLQKKFDDF-NDDLKANEVRLANMNEIAVQLTSLGQTEAALKIQTQM 1156
             :|.     :|:|.|.|.:||::|.:| .|.....:.|:..:|.:|.:|.:.|..:|| .:....
Zfish  1733 GSHE-----LGQDYEHVTMLQERFREFARDTGNIGQERVDGVNRMADELINAGHADAA-TVAEWK 1791

  Fly  1157 QDLNEKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQR 1221
            ..|||.|.:|..|...:...|.:::|:.:|:.|..|....|.:|...| .::||:|..:|:||||
Zfish  1792 DGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEILGRILDKHKKL-PEELGRDQNTVETLQR 1855

  Fly  1222 KHEGVERDLAALRDKIRQLDETANRLMQSHP-DTAEQTYAKQKEINEMWDQIITKSTARKEKLLD 1285
            .|...|.|:.||..::|||.:.|.||..::. |.|:....::.|:.|.|..::.....|:.:|||
Zfish  1856 MHTTFEHDIQALGTQVRQLQDDAVRLQSAYAGDKADDIQRREGEVLEAWRSLLEACEGRRARLLD 1920

  Fly  1286 SYDLQRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAA 1350
            :.|..||.|..|||:.|:..::.|:.:.|...||:..|.|:..||..:|                
Zfish  1921 TGDKFRFFSMVRDLMLWMEDVIRLIETQEKPRDVSSVELLMNNHQGIKA---------------- 1969

  Fly  1351 STSSIASPSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWT 1415
                            |||||..:|.|..:.|..||...||||.|||||:..|...|:|:...|.
Zfish  1970 ----------------EIDARNDSFTACIELGKSLLARKHYASEEIKEKLLQLTDKRKDMIDKWE 2018

  Fly  1416 ERRLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQK 1480
            :|...|...|::..:.||..:||:|:..:|.:|::.:...:...||.|||:||.|:|:....|::
Zfish  2019 DRWEWLRLILEVHQFSRDAGVAEAWLLGQEPYLSSRELGQSVDEVEKLIKRHEAFEKSAATWEER 2083

  Fly  1481 IAALQTVADQLIAQNHYASNLVDEKRKQVLERWR---------HLKEGLIEKRSRLGDEQTLQQF 1536
            .:||:.:.         ...|::.:|.|..|..|         ..::|  |.:.|.|::......
Zfish  2084 FSALERLT---------TLELLEVRRLQEEEERRRKPPSPDPVQAQDG--ETQQREGEQIAQNGL 2137

  Fly  1537 SRDADEIENWIAEKLQLATEESYKDPANIQSKHQKHQAFEAELAANADRIQSV--LAMGGNLIDK 1599
            ..|.|...:.:..::....|.|.|:|:.|.|.....:...::.|....:.|..  ..:.|.|..|
Zfish  2138 PSDQDSPRDGVDGEMNGVAERSSKEPSPIPSPGADRRGKGSQSATLPTKGQETPSAQLEGFLHRK 2202

  Fly  1600 KQCSGSEDAVQKRLTQIADQWE-------------YLTHKT--------TEKSLKLKEA------ 1637
            .:..|.......|      .|.             |..:|.        .|..:.||||      
Zfish  2203 HEWEGHNKKASSR------SWHNVYCVINNHEMGFYKDNKNAGQGIPYHNEIPISLKEAVCEVAV 2261

  Fly  1638 ---NKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKKHQLVEADIVAHEDRIKDMNN 1699
               .|:..:...|.|.:.:|.:.:.   .|:....:.::||........|....|..::....::
Zfish  2262 DYKKKKHVFKLRVTDGNEYLFQAKD---DEEMNTWIQAIQNAGSGSSSSEKSETAPSNQSTPASS 2323

  Fly  1700 QADSLVESGQFDTAGIQEKRQSINER 1725
            :|.:|..:....:.....||....|:
Zfish  2324 RAHTLPATVSMTSESSPGKRDKDKEK 2349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 0/51 (0%)
SPEC 1074..1287 CDD:238103 68/218 (31%)
SPEC 1182..1425 CDD:238103 77/243 (32%)
SPEC 1426..1638 CDD:238103 51/252 (20%)
SPEC 1533..1744 CDD:238103 37/225 (16%)
SPEC 1646..1850 CDD:238103 13/80 (16%)
SPEC 1852..2062 CDD:238103
SPEC 1958..2176 CDD:238103
SPEC 2072..2296 CDD:238103
EFh 2311..2379 CDD:238008
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103 59/212 (28%)
SPEC 154..364 CDD:238103 76/210 (36%)
SPEC 261..470 CDD:238103 72/210 (34%)
SPEC 471..680 CDD:238103 64/215 (30%)
SPEC 682..893 CDD:238103 72/211 (34%)
Spectrin 893..>961 CDD:395348 26/67 (39%)
sptbn1XP_009304586.2 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.820

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