DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alpha-Spec and SPTBN5

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:XP_016877788.1 Gene:SPTBN5 / 51332 HGNCID:15680 Length:3734 Species:Homo sapiens


Alignment Length:3032 Identity:629/3032 - (20%)
Similarity:1147/3032 - (37%) Gaps:834/3032 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 TVEDIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQAASEESY-RD 77
            :||.:|.:...:...........|.:|..||.:.:...|.|:.:|.|:|:.|..|.....:. ||
Human   626 SVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRD 690

  Fly    78 PTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWELLLSRLA 142
            .:.:...:|||:|.||||..|....|.|...|:::..::.........|.:.:...|:||.:|:.
Human   691 LSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVV 755

  Fly   143 EKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQR---KFDEFQKDMASQ 204
            .:|.:||.||:::|:.....|...|::::.:.:.....|||....|.|.|   :.:...:..|::
Human   756 GRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAE 820

  Fly   205 EYRVTEVNQLAD--------------------------------------KLVQDGHPERD---- 227
            ..|:.|..:.|.                                      |:.....|:.|    
Human   821 LRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPN 885

  Fly   228 TITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNRDADETVAWIAEKDVVLSSDDYGRDLAS 292
            ||.:.::.|::.::.|:.||.:|:.:|..|..:..|.....|...|:.::.|:|.......|  :
Human   886 TILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQAD--T 948

  Fly   293 VQALQRKHEGVERDLAALEDKVSTLGAEAQRLCSIHADHSDQIRDKQAEIANYW----------- 346
            ::.:|.|:|.....||..:...:.:.:.|::|...:..:|.||:.:|.|::..|           
Human   949 LEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKA 1013

  Fly   347 --------------------------------------------------------------QSL 349
                                                                          ||:
Human  1014 VQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSV 1078

  Fly   350 TTKARE-----------------------------RKQKLDESYYLHRFLADFRDLVSWINGMKA 385
            ..|..|                             |.::..|:.....||.:.:.|:.|...::|
Human  1079 VVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQA 1143

  Fly   386 IISADELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREHYAAAEIQEKLAALEN 450
            .:.:.|::.|||.|:.||..||:...||...::..:......|.:...:...:.|:...|..|..
Human  1144 QLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQ 1208

  Fly   451 DKSSLLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDF 515
            ....|..|||.|:...::.::||.|.|:.:......|..:|:|..::||:.:....:|:::|.:|
Human  1209 QGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREF 1273

  Fly   516 EKSLAAQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQ 580
            .:.|:....:.:||.....||:..||.||..|.::.|.:.|:...||.:|.:||:.|..|.:.|:
Human  1274 GRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQE 1338

  Fly   581 FERDCDETKGWISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQ 645
            :::|..|...|:.||...|..:......|:...:::|:..|.||.|.:..:|.:..||.||:.::
Human  1339 WKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRR 1403

  Fly   646 HYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHG 710
            ....:.|.||:|.:...||.|.:...::|.:|.:|.||:|..|.::|.:..|.::||.|.|.:.|
Human  1404 PCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETG 1468

  Fly   711 KDLTSVQNLQKKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAP 775
            :||.|.|.|||:|..||:     :.|..:.|:||...:..|                 .||..|.
Human  1469 QDLRSSQRLQKRHQQLES-----ESRTLAAKMAALASMAHG-----------------MAASPAI 1511

  Fly   776 MGERKQHL--LDSLQVQQLFRDLEDEA---------------AWIREKEPIAASTNRGRDLIGVQ 823
            :.|.::||  |:.||.....|.|:.:|               :|:.|..|..:.|:....|.|.|
Human  1512 LEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQ 1576

  Fly   824 NLIKKHQAVLAEINNHEARLLNVISSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQD 888
            :|.:||:.:..|:..|:.::..|:|||.::.......:..|.::.:.|:..|..|:.....|.|.
Human  1577 SLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQC 1641

  Fly   889 LDDSLQAHQYFADANEAESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQ 953
            |..::...|||.|.:|.|.|:.||.|:.:..|||:||.::..|:.||:||..:|..:.::::.|.
Human  1642 LQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELD 1706

  Fly   954 EQAKNCRQQETP----VVDITGKECVVALYDYTEKSPREV------------------------- 989
            :.|:.....|.|    ||....:|.:.||.:......||:                         
Human  1707 QTAQTLTGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQ 1771

  Fly   990 SMKKGDVL----------------------------------------------TLLNSNNKD-- 1006
            :.|.|:.|                                              .::....:|  
Human  1772 AAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQ 1836

  Fly  1007 --W---WKV--------------------------EVNDRQGFVP---AAYIKKIDAGLSASQ-- 1035
              |   |::                          :|.::...:|   |..:..::|.|.:.|  
Human  1837 TAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGL 1901

  Fly  1036 -----------QNLVDN-------------HSIAKRQNQINSQY----------------DNLLA 1060
                       |.|::.             |::.:||..:...:                ..|||
Human  1902 ERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLA 1966

  Fly  1061 ------------LARERQN---------------KL--NETVKAYVLVRE-----AADLAQ---- 1087
                        .||.||:               ||  ::.::|.:..||     |..|.|    
Human  1967 RFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALL 2031

  Fly  1088 --------------------------WIRDK-----ENHAQI--------------------ADV 1101
                                      |.|.:     |...|:                    ...
Human  2032 AAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSA 2096

  Fly  1102 VGEDLEEVEVLQKKFDDFNDDLKANEVR------------------------------------- 1129
            :|..:||||.|.:|.:.|...|.|.:.:                                     
Human  2097 LGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2161

  Fly  1130 ---------LANMNEIAVQ--------------------------------------------LT 1141
                     :|:..:.|.|                                            :|
Human  2162 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMT 2226

  Fly  1142 SLGQTEAAL---------KIQTQMQDLNEKWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWI 1197
            |:.:...||         ::..::|.|.:.|.:|:...|.:..:|........|.:.:|..:.||
Human  2227 SVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWI 2291

  Fly  1198 AEKANALNNDDL----------------------------------------------------- 1209
            .||...:|..||                                                     
Human  2292 QEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIIC 2356

  Fly  1210 --------------------------------------------------------GKDLRSVQT 1218
                                                                    ||||.|||.
Human  2357 QRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQR 2421

  Fly  1219 LQRKHEGVERDLAALRDKIRQLDETANRLMQSHPDTAEQTYAKQKEINEMWDQIITKSTARKEKL 1283
            |.||||.:||::..::.::..|:....||.|..|:.|.....:|:|:.|.|.|:.:::..|:|.|
Human  2422 LLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREAL 2486

  Fly  1284 LDSYDLQRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGA 1348
            ...:..|:..:..::||.....:.:.:.:.........|..::|.||                  
Human  2487 DALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQ------------------ 2533

  Fly  1349 AASTSSIASPSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKA 1413
                          |.:.|:|:...:.......|.:||.|.|..|.:|::.:..|.:....||.|
Human  2534 --------------ECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGA 2584

  Fly  1414 WTERRLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKAINGHE 1478
            |.|.:|||:|.|:|||::...|..|.|:.::|..|.::...:....:|.|:.||:..:..:....
Human  2585 WQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQA 2649

  Fly  1479 QKIAALQTVADQLIAQNHYASNLVDEKRKQVLERWRHLKEGLIE----KRSRLGDEQTLQQFSRD 1539
            .||:||:..|..|....|..:.....:.:.:|.|    ||.|..    :|.||.:.:.||.|.:|
Human  2650 GKISALEATARGLHQGGHPEAQSALGRCQAMLLR----KEALFRQAGTRRHRLEELRQLQAFLQD 2710

  Fly  1540 ADEIENWIAEKLQLATEESYKDPANIQSKHQKHQAFEAELAANADRIQSVLAMGGNLIDKKQCSG 1604
            :.|:..|:.||..:|.||...|.|.:.::.||.|.|:|||.|:..:.|.:...|..|:.    .|
Human  2711 SQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQ----GG 2771

  Fly  1605 --SEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSG 1667
              :.:|:|:||.::...|..|...:.:|..||::|.:......::::|:.||..:|..|.....|
Human  2772 HPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVG 2836

  Fly  1668 KDLASVQNLMKKHQLVEADIVAHEDRIKDMNNQADSLVESGQFDTAGIQEKRQSINERYERICNL 1732
            :.|..|..|:...:.:||.:.....:.:.:..||.:.|..|......::|:.:.:.:|::.:...
Human  2837 QALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREP 2901

  Fly  1733 AAHRQARLNEALTLHQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGSHE 1797
            ...|:..|.....|.:||||..:|.:|::||..|..:.|||:.|:.|::|:::|:.||:|:.|||
Human  2902 LQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHE 2966

  Fly  1798 PAIQAVQEAGEKLMDVSNLGVPEIEQRLKALNQAWAELKNLAATRGQKLDESLTYQQFLAQVEEE 1862
            ...:.|...|.||:...:....|:..|::.|.:|.|.|:..||.|...|.::...||||.::.|.
Human  2967 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEA 3031

  Fly  1863 EAWITEKQQLLSVEDYGDSMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSELVEAKNH----- 1922
            .:|:.|:..:|..||.|.|..|.|.||::.:|.:.|..|...|...: .|.:.|:|::.:     
Human  3032 GSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERL-QQTAALLESRKNPERWA 3095

  Fly  1923 ---------------HGESIAQRCQ---QLRLKLDN-----LSALAARRKGALLDNSAYLQFMWK 1964
                           .|..:.|..:   |.||.|.:     |:.|.|.|:       |:.:.:.:
Human  3096 EATPSAKEQREAPYRDGRRLLQPGKAGLQSRLSLSSHSPKVLAQLQAVRE-------AHAELLRR 3153

  Fly  1965 AD--------------------VVESWIDDKENYVRSDEFGRDLSTVQTLLTKQETFDAGLNAFE 2009
            |:                    ::::|:..|.....|.::|:||..|:.|..|.:.|...:.:..
Human  3154 AEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLG 3218

  Fly  2010 QEGIHNITALKDQLINASHAQSPAILKRHGDVIARWQKLRDASNTRKDRLLAMQE--QFRQ-IEE 2071
            |..::.:..|...|...:..:.|.|..:...:.|.|::|..|...|.:.|.|..|  .|:| ..|
Human  3219 QAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAE 3283

  Fly  2072 LYLTFAKKASAFNSWFENAEEDLTDPVRCNSIEEIRALRDAHAQFQASLSSAEADFKALAALDQK 2136
            |.....:|.:....      ||     ..:|:..:|.|:..|.:.:..|.:.|   |.:|.|  :
Human  3284 LQGRMQEKTALMKG------ED-----GGHSLSSVRTLQQQHRRLERELEAME---KEVARL--Q 3332

  Fly  2137 IKSFNVGP-NPYTWFTMEALEETWRNLQKIIEERDGELAKEA-----------------KRQE-- 2181
            .::..:|. :|.....:..::|.|..||...:||...||:.|                 :|||  
Human  3333 TEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELA 3397

  Fly  2182 ENDKLRKEFA-------KHANLFHQWLTETRYYMLGYNRQGTSMMEGSGSLEQQL-EALRVKATE 2238
            .:::|.::.|       :|..| .|.:.|.|.......::|..:::.|..:..:: |.|:    |
Human  3398 SSEELAEDVAGAEQLLGQHEEL-GQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQ----E 3457

  Fly  2239 VRARRVDLKKIEELGALLEEHLILDNRYTEHSTVGLAQQWDQLDQLSMRMQHNLEQQIQA----- 2298
            :..|   |:::||..||..:.              .|:.|. |.:|..|:     :|.:|     
Human  3458 LEGR---LQELEEAWALRWQR--------------CAESWG-LQKLRQRL-----EQAEAWLACW 3499

  Fly  2299 --------RNHSGVSEDSLKEFSMMFKHFDKDKSGKLNHQEF 2332
                    ..|| ||:..|    ::.:|.|.:|......::|
Human  3500 EGLLLKPDYGHS-VSDVEL----LLHRHQDLEKLLAAQEEKF 3536

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 13/158 (8%)
SPEC 1074..1287 CDD:238103 70/480 (15%)
SPEC 1182..1425 CDD:238103 64/351 (18%)
SPEC 1426..1638 CDD:238103 61/217 (28%)
SPEC 1533..1744 CDD:238103 54/212 (25%)
SPEC 1646..1850 CDD:238103 56/203 (28%)
SPEC 1852..2062 CDD:238103 56/257 (22%)
SPEC 1958..2176 CDD:238103 50/241 (21%)
SPEC 2072..2296 CDD:238103 50/251 (20%)
EFh 2311..2379 CDD:238008 4/22 (18%)
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103 55/255 (22%)
SPEC 154..364 CDD:238103 50/356 (14%)
SPEC 261..470 CDD:238103 50/310 (16%)
SPEC 471..680 CDD:238103 58/208 (28%)
SPEC 682..893 CDD:238103 61/227 (27%)
Spectrin 893..>961 CDD:395348 23/67 (34%)
SPTBN5XP_016877788.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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