DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Spec and actn2

DIOPT Version :9

Sequence 1:	NP_001261286.1	Gene:	alpha-Spec / 38231	FlyBaseID:	FBgn0250789	Length:	2457	Species:	Drosophila melanogaster
Sequence 2:	NP_001005053.1	Gene:	actn2 / 448602	XenbaseID:	XB-GENE-489122	Length:	894	Species:	Xenopus tropicalis

Alignment Length:	865	Identity:	212/865 - (24%)
Similarity:	376/865 - (43%)	Gaps:	229/865 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1666 SGKDLASVQNLMKKHQ--LVEADIVAHEDRIKDMN---------------NQADSLVESGQFDT- 1712
            |.||...:..|:.:|:  |::...:..:|.:.::|               ..|:.:|.:.:.|.
Frog   179 SWKDGLGLCALIHRHRPDLIDYSKLNKDDAVGNINLAMDVAEKYLDIPKMLDAEDIVSTAKPDER 243

  Fly  1713 -------------AGIQEKRQSINERYERICNLAAHRQARLNEALTLHQFFRDIADEESWIKE-- 1762
                         ||.::...:.|    |||.:.|..|.  ||.: :.::.|..::...||:.
Frog   244 AIMTYVSCFYHAFAGAEQAETAAN----RICKVLAVNQE--NERM-MEEYERLASELLEWIRRTI 301

  Fly  1763 ----------------KKLLVGSDDYGRDLTGVQNLKKKHK--------RLEAELG--------S 1795
                            |||    :|:       ::.::|||        :||....        |
Frog   302 PWLENRTSEKTMQAMLKKL----EDF-------RDYRRKHKPPRVQEKCQLEINFNTLQTKLRIS 355

  Fly  1796 HEPAIQAVQEAGEKLMDVSNLGVPEIEQRLKALNQAW--AELKNLAATRGQKLDESLTYQQFLAQ 1858
            :.||.  :...|:.:.|::| ....:||..|...: |  .||:.|  .|.:.|.|     :|..:
Frog   356 NRPAF--MPSEGKMVSDIAN-AWQRLEQGEKGYEE-WLLTELRRL--ERVEHLAE-----KFRQK 409

  Fly  1859 VEEEEAWITEKQQLLSVEDYGD-SMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSELVEAKNH 1922
            ....|:|...|:|||..:||.. |:..|:.||:||:|||::..|.:||...|.....||.|...:
Frog   410 ASLHESWTAGKEQLLLQKDYETASLTEVRALLRKHEAFESELAARQDRVEQIAAIAQELNELDYY 474

  Fly  1923 HGESIAQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFMWKADVVESWIDDKENYVRSDEFGRD 1987
            ....|.:|||::..:.|.|..|..:|:.||
Frog   475 DAARINERCQKICDQWDRLGTLTQKRREAL----------------------------------- 504

  Fly  1988 LSTVQTLLTKQETFDAGLNAFEQEGIHNITALKDQLINASHAQSPAILKRHGDVIARWQKLRDAS 2052

Frog   505 ----------------------------------------------------------------- 504

  Fly  2053 NTRKDRLLAMQEQFRQIEELYLTFAKKASAFNSWFENAEEDLTDPVRCNSIEEIRALRDAHAQFQ 2117
             .|.::||      ..:::|:|.|.|:|..||.|.|.|.|||.|....:::|||:.|..||.||:
Frog   505 -ERTEKLL------ETVDQLHLEFIKRAGPFNIWMEGAMEDLQDMFIVHNVEEIQKLITAHEQFK 562

  Fly  2118 ASLSSAEADFKALAAL----DQKIKSFNV---GPNPYTWFTMEALEETWRNLQKIIEERDGELAK 2175
            |:|..|:::.:|:..:    ::.|:|:|:   ..|||:..|::.:...|..:::::..||..|.:
Frog   563 ATLPEADSERQAILGIQNEVEKVIQSYNIKISSHNPYSSITLDEIRTKWEKVKQLVPIRDQTLQE 627

  Fly  2176 EAKRQEENDKLRKEFAKHANLFHQWLTETRYYMLGYNRQGTSMMEGSGSLEQQLEALRVKATEVR 2240
            |..||:.|::||::||..||:...|:.:.      ....|.|.::.:|:||.|:.:|::....:.
Frog   628 ELARQQNNERLRRQFAGQANVIGPWIQKQ------MEEIGRSCIDFTGTLEDQMNSLKMLEHNIV 686

  Fly  2241 ARRVDLKKIEELGALLEEHLILDNRYTEHSTVGLAQQWDQLDQLSMRMQHNLEQQIQARNHSGVS 2305
            ..:.::.|:|....:::|.||.||::|.:|...:...|:.:.....|..:.:|.||..|:..|::
Frog   687 NYKHNVDKLEGDHQMIQESLIFDNKHTNYSMEHIRVGWELMLTTVARTINEVETQILTRDAKGIT 751

  Fly  2306 EDSLKEFSMMFKHFDKDKSGKLNHQEFKSCLRALGYDLPMVEEGQPDPEFEAILDVVDPNRDGYV 2370
            ::.:..|...|.||||.|:|.:.|.:|::||.::||||       .:.||..|:.:|||:..|.:
Frog   752 QEQINVFRSSFNHFDKKKNGLMEHDDFRACLISMGYDL-------GEAEFARIMALVDPSGIGTI 809

  Fly  2371 SLQEYIAFMISKETENVQSYEEIENAFRAITAADRPYVTKEELYCNLTKDMADYCVQRMKPFSEP 2435
            |.|.:|.|| ::||....:.|::..||| |.|||:||:..|||...|..:.|.||:.:|..::.|
Frog   810 SFQSFIDFM-TRETAETDTSEQVIAAFR-ILAADKPYILPEELRRELPPEQAQYCLSKMPTYTGP 872

  Fly  2436 RSGQPIKDALDYIDFTRTLF 2455
            .:   :..|||:..|:..|:
Frog   873 GA---VPGALDFTCFSSALY 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Spec	NP_001261286.1	SH3_Alpha_Spectrin	974..1026	CDD:212742
		SPEC	1074..1287	CDD:238103
		SPEC	1182..1425	CDD:238103
		SPEC	1426..1638	CDD:238103
		SPEC	1533..1744	CDD:238103	21/108 (19%)
		SPEC	1646..1850	CDD:238103	49/250 (20%)
		SPEC	1852..2062	CDD:238103	38/210 (18%)
		SPEC	1958..2176	CDD:238103	40/224 (18%)
		SPEC	2072..2296	CDD:238103	67/230 (29%)
		EFh	2311..2379	CDD:238008	26/67 (39%)
		EFhand_Ca_insen	2386..2456	CDD:400872	24/70 (34%)
		SPEC	48..258	CDD:238103
		SPEC	154..364	CDD:238103
		SPEC	261..470	CDD:238103
		SPEC	471..680	CDD:238103
		SPEC	682..893	CDD:238103
		Spectrin	893..>961	CDD:395348
actn2	NP_001005053.1	CH_ACTN_rpt1	35..139	CDD:409063
		CH_ACTN_rpt2	143..257	CDD:409065	11/77 (14%)
		Spectrin	281..390	CDD:395348	22/124 (18%)
		SPEC	402..629	CDD:238103	77/338 (23%)
		Spectrin	637..739	CDD:395348	25/107 (23%)
		FRQ1	750..860	CDD:227455	44/118 (37%)
		EFhand_Ca_insen	824..890	CDD:400872	24/70 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010