DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alpha-Spec and Dys

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster


Alignment Length:3032 Identity:548/3032 - (18%)
Similarity:1041/3032 - (34%) Gaps:863/3032 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 DIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQAASEESYRDPTNL 81
            |:|.:   :|.|..:|      :::|||..|:|.....|.....|.|...|:.| |:...:...|
  Fly   413 DVQAK---ILMRLAEF------QKQKLEQLRQFLTSVEDRISHMSDIGPTLEEA-EKQLLEAQKL 467

  Fly    82 QAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWELLLSRLAEKGL 146
            :|.:.:.|..   |.:.|:.:|.:::|....        ..::.||..|.:.|..::.....:..
  Fly   468 KADLSEQQEL---VDSLSSMVVIVNDTSGNF--------NDLEDRLSALGERWSHVVKWSDLRKE 521

  Fly   147 KLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQ---KDMASQEYRV 208
            ||||        .:|  :..|:..:|..:...| .:|:..|..:.::.:|..   ||:...:..:
  Fly   522 KLQQ--------YKC--ISRWLDAREQDLKLME-SRDVTDVGGITQRINELNYCAKDLLELQRYL 575

  Fly   209 TEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFN--RDA---- 267
            .::.|:....:|||..:.:.:..:.|...:....|||:..|:..::    |.:.||  ||.    
  Fly   576 IDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRI----ETKGFNFGRDRASYD 636

  Fly   268 DETV----AWIAEKDVV------LSSDDYGRDLAS----------VQALQR---KHEG----VER 305
            |..|    .|:..:.::      ...||...||||          ..||:.   :|.|    ||:
  Fly   637 DSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALENHIMEHFGYVQEVEQ 701

  Fly   306 DLAALE--------DKVSTLGAEAQRLCS----------------------IHADHSDQIRDKQA 340
            .|..|:        :.:..|.||..|.|.                      :...|..|:..:.|
  Fly   702 KLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLEETHIKQLEQRYA 766

  Fly   341 EIANYWQSLTTKARERKQKL-DESYY--LHRF---LADFRDLVSWINGMKAIISADELAKDVAGA 399
            .::   |.|:::..|....| .|.||  |..|   |||.||   |........|.:||.:.::..
  Fly   767 NLS---QKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRD---WYKQHAGSASGNELEQRLSHM 825

  Fly   400 EALLERHQEHKGEIDAREDSF----------------------KLTTESGQKLLEREHYAAAEIQ 442
            |:|.....|.|...:..:|:.                      .|..:.|.:.|.|:   ..:||
  Fly   826 ESLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHDMKQALQALIQQRGGESLSRQ---LKQIQ 887

  Fly   443 EKLAALENDK--SSLLSLWEDRRILYEQCMD----LQLFY-----------------RDTEQADT 484
            :.:..:.|.|  .|.|.:.::::....|.:|    |:|.|                 |..||.:.
  Fly   888 DFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLIGEELQTAWNRLPEQLNE 952

  Fly   485 WMAKQEAFLAN-------------------------------EDLGD-SLDSV------EALIKK 511
            .:.||...:.|                               :||.. .:|.:      |.|||:
  Fly   953 RVIKQTTAIENLNHFAAEYNAIIAMLRSAADSKLNGSDGASSQDLRKLEIDVISARNFSEILIKE 1017

  Fly   512 HEDFEK-SLAAQEEKIKAL----------------------DIFATKLIDGQHYAAD-------- 545
            .|..:| ||.:|...:..|                      |:...:|.:...:..|        
  Fly  1018 AEPAQKESLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQLRLKETDQWLTDLESNTPKS 1082

  Fly   546 ---DVAQRRQMLLAR------RAALQEKSSKRRQL-------------LEDSNR-------YQQF 581
               |:....::..::      :...:.::::.|.|             |:|.:|       .:||
  Fly  1083 GISDIVNSNELFQSKSRFQTLKETCERETTQFRDLNERGGELLLQMDELQDQDRESRYGSLAKQF 1147

  Fly   582 ERD-----------------CDETKGWISEKLKF-ATDDSYLD---------PTNLNGK---MQK 616
            .|.                 .:.....:.|..|| .::..|||         |.|....   |::
  Fly  1148 TRINARWTEVTELVYAKTALLEHISTQLGEFKKFMVSETGYLDKLENKIRNTPENAADAEEIMEE 1212

  Fly   617 HQNFEHELNANKSR-IEDITNVGTELIEKQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNE- 679
            ..:.|:.|.::... ::.|..:|.|||:.: :.||.|...:.|.|..| |.:|...||.|:|.| 
  Fly  1213 LDDLENVLRSHSEEWLDKIQEIGNELIDNE-FMADSIRRDIDETVQRW-TQLQQQAKKRTELLEQ 1275

  Fly   680 -ACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVA 743
             ..:.:|..:.|...|.||:.:: .:||:....|:|.|...::...|.. :.:|::...:.|...
  Fly  1276 KVSEAEQSEKCIVQFEKWLTRVD-DILSDHLDNDVTIVDQPEEFQRLAH-EFVANEKNFKEISEL 1338

  Fly   744 ANKFIESGHFDADNIRNKEGNL-SARYAALAAPMGE--RKQHLLDSLQVQQLFRDLEDEAAWIRE 805
            .::...:|...|.|...::.|| ..|:....|.:.:  ..||..:| ::.:.:.||.:.......
  Fly  1339 IDEHTRNGKVGAANRLQEQLNLMEVRFKYCQAKLSKCTAIQHSYES-RLNRAYTDLRNVERSTEV 1402

  Fly   806 KEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLNVISSGENMLKDQPFAS-DDIRQRLE 869
            .:..:|..|.      ||...:|...:...::..::.:.:.|.:|..:.:|:...| ..:.||::
  Fly  1403 VDVASAGPNT------VQTQYQKCLQIYRTLSEIKSEIESTIKTGRRVCEDRYTKSPKQLSQRID 1461

  Fly   870 ALQEQWNTLKEKSSQRKQDLDDSL----QAHQYFADA-------------NEAESWMREKEPIAT 917
            ||:..:|||.|..:|.|..|:..|    |..:.|..|             ::..|.:.|.|.:..
  Fly  1462 ALKHLYNTLGENVTQSKATLERLLTLARQLEECFDSADNLIRRFESPQEVHDRNSILLEFEDVLR 1526

  Fly   918 G-----SDYGKDED---------------------SSEALLKKHEALVSDLEAFGN----TIQAL 952
            .     ::|.|..|                     :|..::|:...:.:.|:...|    |::|:
  Fly  1527 RCEDHYNEYNKSCDQSCMVETRQRIDGLKATYHKLTSADIIKRLTEMKTTLQNLDNISLETLRAM 1591

  Fly   953 QEQAKNCRQQETPVVDITGKECVVALYDYTEKSPREVSMKKGDVLTLLNS---NNKDWWKVEVND 1014
            :...|.......|.::...::.:..:.|..:....|.:     .|...|:   :|.|...|.|:|
  Fly  1592 EHDLKEINVPSNPEIEKLQQQVIAIVVDVLKTRFNEAT-----TLAARNTSSPDNDDTEIVVVSD 1651

  Fly  1015 ----RQGFVPAAYIKKIDAGLSASQQ--------------------------NLVDNHSI----- 1044
                |:...|.:......|..|:|:.                          .|.::.::     
  Fly  1652 TVRQRRARTPQSGESPSSAHTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQIS 1716

  Fly  1045 --------------AKRQNQI-------------NSQYDNLLAL---ARERQNKLNETVK----- 1074
                          ||.:.:.             |.|.|.:...   ...:|.::.:||.     
  Fly  1717 LNPQKVTNTPPPKPAKTKRKAPSSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESV 1781

  Fly  1075 -----AYVLVREAADLA--------------QWIRDKENHA-------QIADVVGEDLEEVEVL- 1112
                 .||...:..||:              :..|.|..|:       :::|...:..|:.|.| 
  Fly  1782 EPFVPEYVETVQIVDLSEDSDSSVRVDSQGKEMRRSKSKHSLNETPLPKVSDNDEDSAEQEEDLL 1846

  Fly  1113 --------------QKKFDDFNDDLKANEVRLANMNEI----AVQLTSLGQTEAALKIQTQMQDL 1159
                          :|:...|::..|    |:||..:|    ..:......|..|.::...    
  Fly  1847 RPSAENTSTPFLRVEKRRISFDEKRK----RVANERDILRDSEEEEPKTPDTPRAAQVSKP---- 1903

  Fly  1160 NEKWNNLQ----TLTAEKASQ------------------LGSAHEVQRFHRDIDETKDWIAEKAN 1202
             ::|..||    .|..|...:                  .....::.||..::..|.|..::.:.
  Fly  1904 -KRWRQLQPEMDALEPESPGRDSFYSPDKESGFDAEPLVFSDDEDIPRFSLEMTSTIDSDSDTSR 1967

  Fly  1203 ALN------NDDLGKDLRSVQT------LQRKHEGVERDLAALRDKIRQLDETANRLMQSHPDTA 1255
            .:.      |..|.|.|.|:.:      :..|....|.....|.|::|:.|:.|.:::..    .
  Fly  1968 IMTPSTKNPNPFLSKVLESLSSPVDDSNVTLKSPISEEQPQNLDDRVREFDKQAKQMIYK----L 2028

  Fly  1256 EQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRFLSDYRDLLAWINSMMSLVTSDELANDVT 1320
            :.|.||.::.:|        |.|...:||.:.|....:|....|:...:.....::...:...:.
  Fly  2029 KLTKAKIEQCHE--------SEAEDLRLLIAPDAATLISQGDSLVLETHGRQGSISRLVMRTQII 2085

  Fly  1321 GAEALIERHQARRAEIGFTLGISSAPGAAASTSSIASPSGDEEHRTEIDARAGTFGAFEQFGNEL 1385
            ..|...|..|||....|     |.||.....:.:|      ||..|:...|.          |.|
  Fly  2086 LREQFREVQQARSKTSG-----SGAPAPPLDSVNI------EELVTKGLRRI----------NVL 2129

  Fly  1386 LQ--ANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLYMRDCELAESWMSAREAFL 1448
            ::  .:..:|.::::::||:.:..:||:...:......:......|.|.:.|..::.:.|     
  Fly  2130 IEKTVDLKSSTDLEKRMEDINERHDDLQVIVSAIGKNAQMPKVTPLMMNEIEKTKNNLIA----- 2189

  Fly  1449 NADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQTVADQLIAQNHYASN---LVDEKRKQVL 1510
            :||       ::|..:.:..:..:..||.|:..|:...........|:..|.   |.....|.||
  Fly  2190 HAD-------SIELSLTELRNGPRISNGKERPDASSAATMSCRSEYNNEPSGTGALAGSFDKSVL 2247

  Fly  1511 E--RWRHLKEGLIEKRSRLGDEQTLQQFSRDADEIENWIAEKLQLATEESYKDPANIQSKH---- 1569
            :  .|...::.:|:.:|.|.|         |.|.:...|.::.::..|...|.|...:..|    
  Fly  2248 QISDWLTWEQNMIKIQSVLVD---------DGDAVRLAIEKQEKVLRELKMKKPQLNELVHTAEV 2303

  Fly  1570 -----QKHQAFEAELAANADRIQSVLAMGGNLIDKKQCSGSEDAVQ--KRLTQIADQWEYLTHKT 1627
                 ::.|..|.||.      |..||        ..||...|.::  .::|::.:.|:..:...
  Fly  2304 LKGDVKRQQLQEKELK------QFSLA--------PHCSADLDYMRCCLKVTRLREHWDETSQCV 2354

  Fly  1628 TEKSLKLKE--ANKQRTYIAAVKDLDFWLGEVE-------SLLTTEDSGKDLASVQNLMKKHQLV 1683
            .:::.:||.  ::.|| :.|...:|:.||..:|       ::.||.|      .::...|:.:..
  Fly  2355 LQRAAQLKNMLSDSQR-FEAKRLELEKWLARMEQRAERMGTIATTAD------ILEAQQKEQKSF 2412

  Fly  1684 EADIVAHEDRIKDMNNQADSLVE-SGQFDTAGIQEKRQSINERYERICNLAAHRQARLNEAL-TL 1746
            .|::..::......|.....|:. ....||..|::..:.||:||..:.:...:|..:|:.|: :|
  Fly  2413 HAELHQNKQHFDIFNELTQKLIAVYPNDDTTRIKKMTEVINQRYANLNSGVINRGKQLHAAVHSL 2477

  Fly  1747 HQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGSHEPAIQAVQEAGEKLM 1811
            ..|.|.:....:::.|.:.|..:.:     :.::......|.|::|:.:|......:...|.||:
  Fly  2478 QSFDRAMDQFLAFLSETETLCENAE-----SDIERNPLMFKDLQSEIETHRVVYDRLDGTGRKLL 2537

  Fly  1812 D--VSNLGVPEIEQRLKALNQAWAELKNLA-ATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLL 1873
            .  .|......:::||..:||.|..||:.: |.|.:....|..:...|..:.|...|:..|...|
  Fly  2538 GSLTSQEDAVMLQRRLDEMNQRWNNLKSKSIAIRNRLESNSEHWNALLLSLRELTEWVIRKDTEL 2602

  Fly  1874 SVEDYG---DSMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSELVEAKNHHGESIAQRCQQLR 1935
            |....|   ....::|..|..|.||                                       |
  Fly  2603 STLGLGPVRGDAVSLQKQLDDHKAF---------------------------------------R 2628

  Fly  1936 LKLDNLSALAARRKGALLDNSAYLQFMWKADVVESWIDDKENYVRSDEFGRDLSTVQTLLTKQET 2000
            .:|::                       |..:|||.:.....|:.::....|.|..:   ...::
  Fly  2629 RQLED-----------------------KRPIVESNLTSGRQYIANEAAVSDTSDTE---ANHDS 2667

  Fly  2001 FDAGLNAFEQEGIHNITALKDQLINASHAQSPAILKRHGDVIARWQKLRDASNTRKDRL---LAM 2062
            ....::|.||                |...:.:|.:..|.:..:|..|.|.|:..|.||   :..
  Fly  2668 DSRYMSAEEQ----------------SRELTRSIRREVGKLSEQWNNLIDRSDNWKHRLDEYMTK 2716

  Fly  2063 QEQFRQI-EELYLTFAKKASAFNSWFE-----NAEEDLTDPVRCNSIEEIRALRDAHAQFQASLS 2121
            ..||::| |:|....|.......||..     .|.|.:         ::::.|||......|.|.
  Fly  2717 MRQFQKILEDLSSRVALAEQTKTSWLPPSSVGEANEQM---------QQLQRLRDKMTTASALLD 2772

  Fly  2122 SAEADFKALAALDQKIKSFNVGPNPYTWFTMEALEETWRNLQKIIEERDGELAKEAKRQ--EEND 2184
            ..........|....:      |.| ....:|.|....:.||..::||...|.:...:|  |..|
  Fly  2773 DCNEQQSFFTANQVLV------PTP-CLSKLEDLNTRMKLLQIAMDERQKVLCQAGAQQTHENGD 2830

  Fly  2185 KLRK-----EFAKHANLFHQ----WLTETRY----YMLGYNRQGT--------SMMEGSGSLEQ- 2227
            ..|.     ......||...    |...|..    |.:.:.|:.|        .:|:|...|.: 
  Fly  2831 DGRTTSNSGTIGPLPNLGQSVKPPWERATTAANVPYYIDHERETTHWDHPEMIELMKGLADLNEI 2895

  Fly  2228 ----QLEALRVKATE---------------------VRARRVDLKKIEELGALLEEHLILDNRYT 2267
                ...|:::::.:                     :||:...|..|.::..:|....:..::..
  Fly  2896 RFSAYRTAMKLRSVQKRLALDRISMSTACESFDRHGLRAQNDKLIDIPDMTTVLHSLYVTIDKID 2960

  Fly  2268 EHSTVGLAQQW----------DQLDQLSMRM------QHNLEQQIQARNHSGVSEDSLKEFSMMF 2316
            ....:.||..|          .|:..||.::      :.:||::.:.........|         
  Fly  2961 LTLMLDLAINWILNVYDSQRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFRLVADTD--------- 3016

  Fly  2317 KHFDKDKSGKLNHQEFKSCL---RALGYDLPMVEEGQPDPEFEAIL-------DVVDPNRDGYVS 2371
            :..|:.:.|.|.|    .|:   |.|| ::........:|...:.|       :.:|.|:|..:.
  Fly  3017 RRADQRRLGLLLH----DCIQVPRQLG-EVAAFGGSNIEPSVRSCLEQAGISQEAIDGNQDISIE 3076

  Fly  2372 LQEYIAFMISKETENVQSYEEIENAFRAITAADRPYVTKEELYCNLTK----------------- 2419
            ||.::.::    ....||...:....| :.||:   ..|.:..||:.|                 
  Fly  3077 LQHFLGWL----QHEPQSLVWLPVLHR-LAAAE---AAKHQAKCNICKEYPIVGFRYRCLKCFNF 3133

  Fly  2420 DMADYCVQRMKPFSEPRSGQPIKD-------ALDYIDFTRTL 2454
            ||...|....:.....:...|:.:       ..|..||||.|
  Fly  3134 DMCQKCFFFGRNAKNHKLTHPMHEYCTTTTSTEDVRDFTRAL 3175

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 11/58 (19%)
SPEC 1074..1287 CDD:238103 49/296 (17%)
SPEC 1182..1425 CDD:238103 48/256 (19%)
SPEC 1426..1638 CDD:238103 43/229 (19%)
SPEC 1533..1744 CDD:238103 44/231 (19%)
SPEC 1646..1850 CDD:238103 43/215 (20%)
SPEC 1852..2062 CDD:238103 34/215 (16%)
SPEC 1958..2176 CDD:238103 45/226 (20%)
SPEC 2072..2296 CDD:238103 49/293 (17%)
EFh 2311..2379 CDD:238008 15/77 (19%)
EFhand_Ca_insen 2386..2456 CDD:400872 19/93 (20%)
SPEC 48..258 CDD:238103 40/212 (19%)
SPEC 154..364 CDD:238103 53/276 (19%)
SPEC 261..470 CDD:238103 63/301 (21%)
SPEC 471..680 CDD:238103 64/360 (18%)
SPEC 682..893 CDD:238103 45/214 (21%)
Spectrin 893..>961 CDD:395348 17/114 (15%)
DysNP_001036722.1 CH 13..111 CDD:278723
CH 129..225 CDD:278723
SPEC 312..525 CDD:238103 29/132 (22%)
SbcC <325..957 CDD:223496 120/588 (20%)
Smc <816..1591 CDD:224117 142/788 (18%)
SPEC 1174..1365 CDD:238103 47/194 (24%)
SPEC 1289..1485 CDD:295325 43/204 (21%)
SPEC 2369..2576 CDD:238103 46/218 (21%)
SPEC 2477..2714 CDD:238103 57/322 (18%)
WW 2852..2882 CDD:238122 5/29 (17%)
EF-hand_2 2883..2997 CDD:286194 15/113 (13%)
EF-hand_3 3001..3100 CDD:286195 21/117 (18%)
ZZ_dystrophin 3110..3158 CDD:239074 7/47 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439920
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR11915
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.030

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