DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alpha-Spec and kst

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_001097492.2 Gene:kst / 38418 FlyBaseID:FBgn0004167 Length:4337 Species:Drosophila melanogaster


Alignment Length:2992 Identity:715/2992 - (23%)
Similarity:1245/2992 - (41%) Gaps:746/2992 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 DIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQAASEESY-RDPTN 80
            :||.|.:.:...:...:.....:|.:|||:.....|..||:|.|||::||:...:...| .|..:
  Fly   732 EIQSRIDSLAEHWQALEALVELRRRQLEDAAEAYQFYTDANEAESWLNEKIALVNSRDYGNDEPS 796

  Fly    81 LQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMIN------------------------------- 114
            .||.:|:|:..:.|::|:|..|::|:....::|.                               
  Fly   797 AQALLQRHRDLQGELNAYSGDILNLNQQADKLIKAGICTLELSAAEPELPEVEQEEWVNETRLVP 861

  Fly   115 ----------------------------------------------------------------- 114
                                                                             
  Fly   862 KEVWEDEWVEKLEHKKVTETKMLPHVKSLFPFEGQGMKMDKGEVMLLKSKTNDDWWCVRKDNGVE 926

  Fly   115 ----------------------------------------------------------QQHFASE 121
                                                                      |:..:::
  Fly   927 GFVPANYVREVEPRPVACIVPKAEKVKSLQKVKKTILVRQVVPVKRIKPVSVAPKPLVQRRTSTQ 991

  Fly   122 SIQVRLDELHKLWELL------LSRLAEK-GLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADE 179
            ||....|.:.|..:.:      |..:|:| ...|:.::.|..|.|:|::...|:|:||..:.:||
  Fly   992 SINENADSVEKRQQRINQTYDELQEMAQKRHALLEDSIHLFGFYRECDDFEKWMKEKERMIKSDE 1056

  Fly   180 FGQDLEHVEVLQRKFDEFQKDMASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLK 244
            .    |.|:..:|||::|..|:::...||.|::...|...:.||.:.|.|..|:.::::.||||.
  Fly  1057 G----EGVDNAKRKFEKFITDLSAASKRVEEIDGAVDTFRRQGHSQLDKIIARQRQIHQIWQRLN 1117

  Fly   245 QLAIVRQEKLFGAHEIQRFNRDADETVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLAA 309
            .....|::.|.||..::.|||..||...|::||.:.|.:.....||.:||||||:|:.:||:||.
  Fly  1118 NAKAQREKSLEGASSVELFNRTCDEAKVWMSEKMLQLDTAVITPDLRTVQALQRRHQNLERELAP 1182

  Fly   310 LEDKVSTLGAEAQRLCSIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFR 374
            :||||:.:......:.:.:....|.:..:|.|:.:.||.:..:..:.:.:::.......|....:
  Fly  1183 VEDKVNRVTYLGNSVKNAYPAEKDNVNARQQEVQDMWQQVQQRGSDLRNRIESEVGQQVFNNSAK 1247

  Fly   375 DLVSWINGMKAIISADELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREHYAAA 439
            .|::||:.:|..::|||.|:||..|..||::|.:...:|.|.:..|....:.|::|.:    ...
  Fly  1248 VLLAWIDSVKDQLNADESARDVETANNLLKKHNDLGDDIRAHDTEFVEVIQLGKQLSD----GKP 1308

  Fly   440 EIQEKLAALENDKSSLLSL---WEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDS 501
            .:.|.:|.:|..|:...::   |.:::....||:|||:|.|:.::.|......||||...:||.|
  Fly  1309 NMAETVAVIERLKAEQDAIHRGWAEKQKWLLQCVDLQMFNREADKIDATTKSHEAFLEYNNLGAS 1373

  Fly   502 LDSVEALIKKHEDFEKSLAAQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSS 566
            ||.|||::|:|.||||||.||::.:|.....|.|||...||.:..:..||..:|.:|.|:::::.
  Fly  1374 LDEVEAILKRHLDFEKSLMAQDKILKGFSDNADKLISNDHYDSKYIGDRRNQVLGKRKAVKDRAF 1438

  Fly   567 KRRQLLEDSNRYQQFERDCDETKGWISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRI 631
            :|::||:.|..:.:|..:.|:.|.|:.:|.:.|.|::|.|.:||..|:||||.||.||.||:.::
  Fly  1439 ERKRLLQASKDFHKFAAEADDLKVWLQDKTRIAGDENYRDLSNLPRKLQKHQAFERELRANEGQL 1503

  Fly   632 EDITNVGTELIEKQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELW 696
            .::|..|..|::..: ...::.:|:.::...|:.|:..|:.||.||.:|..|::.||::||.:..
  Fly  1504 RNVTKDGQALVQAGN-RVPEVESRVADLNKRWKDLLTLSEDKGRKLEQAASQREHNRSLEDAKKK 1567

  Fly   697 LSEIEGQLLSEDHGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNK 761
            :.|::..|.|.|.|.||.|.::|..|..:||:::.....::..:....:.....|||:|.||...
  Fly  1568 VDELDSALRSGDVGNDLRSCKDLINKQQILESEITIWDQKVAELVSTGDDMAHGGHFNAQNIEAG 1632

  Fly   762 EGNLSARYAALAAPMGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLI 826
            ...|..|:..|..|...|:..|.:||...:...:|:.|..||.|..|.|.|...|::|...|:|.
  Fly  1633 TKELQQRFKDLRDPTQRRRAKLEESLNYHKFVFELDSEFQWINEHLPAAKSNELGQNLHQAQSLH 1697

  Fly   827 KKHQAVLAEINNHEARLLNVISSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDD 891
            |||:.:.|||..|:..:...:.:|::::..|....:.:....:.|::.|..|:....:|.:.||.
  Fly  1698 KKHKKLEAEIKGHQPMINKALVAGQSLISQQHPEREQVESLCQQLEQAWQDLERHCGERSRKLDM 1762

  Fly   892 SLQAHQYFADANEAESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAF----------- 945
            ||:|.||..||.|.|||:.|:..:...::||:|.||:..||.||:.:..:|:.:           
  Fly  1763 SLKAQQYLFDAGEIESWLGERNNVLRSTEYGRDRDSAAKLLTKHKTIELELDTYSGIVTEMGHSC 1827

  Fly   946 ------------------------------------GNTIQAL------------------QEQ- 955
                                                |..:::|                  ||| 
  Fly  1828 AAMVAANHPDSKVLAAKQQLIEKMLKSLHKLASQRQGRLMESLYKHEYFLESDEVEQWIREQEQA 1892

  Fly   956 ----------------------------------------AKNCRQQETPVVDITGK-------- 972
                                                    ||.....|:|..:...|        
  Fly  1893 ASSEDYGQDFEHLQLLQNKFDDLKHRVEVGADRVDQCELLAKKLIDSESPYANEVEKRQEQLRTS 1957

  Fly   973 --------------------------ECVVALYDYTEKSP------------------------- 986
                                      :...||:...:|:.                         
  Fly  1958 WENLLQLLNQREQKLHAAGEIHRFHRDVAEALFRIQDKNAALSQELGRDLNSALALLRKHEGFEN 2022

  Fly   987 --------------------------------------------REVSMKKGDVL-------TLL 1000
                                                        :|.|..:||.|       |.|
  Fly  2023 DLVALEAQLQVLVEDSVRLQAKYPSNASAIAQQQDKVVAAWNDLKERSTARGDRLAASSDLQTFL 2087

  Fly  1001 ---------NSN-----------------------------------NKDWWKVEVND---RQGF 1018
                     :||                                   :|..:..|::|   :.|.
  Fly  2088 TDVRDIVSWSSNLRAALQAEEHVSDAAGATALKIQHDAIYGEIEAREDKFRYLNELSDSMVQTGH 2152

  Fly  1019 VPAAYI--------------------------------------KKID-------AGLSASQ--- 1035
            ..||.:                                      |:||       |.||:|.   
  Fly  2153 YAAADVEEKCAAMLDERQKLHAAWNKKKIMLEQKIDLFCFLRDAKQIDNLSSSQQAALSSSDFGQ 2217

  Fly  1036 -----QNLVDNHSIAKRQNQINSQYDNLL------------------------ALAR-------- 1063
                 ||.:..|...:|..|...:..:||                        .|||        
  Fly  2218 TVEDVQNKIRKHDEFERLIQTQEEKVSLLQEHGRKLIEQRHYDSANIQTILQGVLARRQKVKDLC 2282

  Fly  1064 ----------------------------ERQNKLN------------------------------ 1070
                                        |:|.||.                              
  Fly  2283 AVRRYKLEDALLYAKFVRDCAEAKYWINEKQKKLEADAASYAEVTNLDEKIKKLQKHQAFQAEVA 2347

  Fly  1071 -------------------------ETVKAYVLVREA-----ADLAQ------------------ 1087
                                     |..:|..:|.||     |:|.|                  
  Fly  2348 ANQGRIQEIQDTGVILLSKQHESSPEIKRAIEIVLEAWQGLLAELEQRGRGLEEAQDSLEFNSQL 2412

  Fly  1088 -----WIRDKENHAQIADVVGEDLEEVEVLQKKFDDFNDDLKANEVRLANMNEIAVQLTSLGQTE 1147
                 ||||||...|.:| .|.|||....|.:|.||.:.|::.::.|:.::|::|.:|.:..|..
  Fly  2413 DKIEAWIRDKEMMVQASD-TGRDLEHCNALMRKLDDVDSDMRVDDQRVKHINQLADKLINQAQVP 2476

  Fly  1148 A-ALKIQTQMQDLNEKWNNLQ-TLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLG 1210
            | ...:..:.:|.|..|..|| .|.|.:| .||.|:|:..|:||:|:|.|.||||:.|:::.|.|
  Fly  2477 ADTQSVDKRRKDFNYNWRQLQGALNAYRA-LLGGANEIHVFNRDVDDTADRIAEKSLAMSSTDTG 2540

  Fly  1211 KDLRSVQTLQRKHEGVERDLAALRDKIRQLDETANRLMQSHPDT-AEQTYAKQKEINEMWDQIIT 1274
            :||.:|:.|.|:.|.:|||::|::.||.|.:..|..|::.:|:. |:....|.:|:::.|..:..
  Fly  2541 RDLAAVEALIRREEALERDMSAVKQKIDQHETAAEFLIKKYPERGAQHIERKLEELHKSWGNLQA 2605

  Fly  1275 KSTARKEKLLDSYDLQRFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFT 1339
            .|..|:..|.::|...:|:||.::|..|:|.|:..:.:.:..:.:...|..:|.||         
  Fly  2606 LSVKRQSILNEAYLAHKFVSDVKELELWVNDMIKKMNNTQSPSTINDCETQLELHQ--------- 2661

  Fly  1340 LGISSAPGAAASTSSIASPSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPE-IKEKIEDL 1403
                                   |.:.||:.|...|...:|.|.:|.:......|: :::.:..|
  Fly  2662 -----------------------ERKVEIEGRQEAFAGLKQQGEQLSKRPQQQQPDNVRKYLLVL 2703

  Fly  1404 AKAREDLEKAWTERRLQLEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHE 1468
            .:..:.|.:||:||...|.:...|||:....|..|.|::.:|||||.||..::...||.|:|||:
  Fly  2704 EELHQTLNEAWSERARDLTEAHQLQLFKAQVEQVEIWLANKEAFLNNDDLGDSYTAVERLLKKHD 2768

  Fly  1469 DFDKAINGHEQKIAALQTVADQLIAQNHYASNLVDEKRKQVLERWRHLKEGLIEKRSRLGDEQTL 1533
            :|:|.:  |...:..||..|:.::......::|:.||...:|.|.:.|.|...|::.||.....|
  Fly  2769 EFEKLL--HADHVDTLQKFANSILEGEPKDADLIREKLAYILRRKQKLLELSEERKQRLTQSHQL 2831

  Fly  1534 QQFSRDADEIENWIAEKLQLATEESYKDPANIQSKHQKHQAFEAELAANADRIQSVLAMGGNLID 1598
            |:|.|...||:.|:.:|||:|.:|:|::|:|:|||.|||.||:|||.:|:.|:|||:..|..||.
  Fly  2832 QEFLRSLYEIDRWLVQKLQVALDENYREPSNLQSKIQKHAAFDAELLSNSPRVQSVIHEGERLIR 2896

  Fly  1599 KKQCSGSEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTT 1663
            ....:..|.|.|.:|  :...|..|...:..|..||::|.....:..:|.:.:.|:.|||..|::
  Fly  2897 GDHFAKDEIAQQVQL--LEGDWLKLKGASQTKKDKLQQAYDALAFNRSVDEFNNWMDEVELQLSS 2959

  Fly  1664 EDSGKDLASVQNLMKKHQLVEADIVAHEDRIKDMNNQAD-SLVESGQFDTAGIQEKRQSINERYE 1727
            ||.|||||:|.||:|||:.:||| |||...:.|...|.| ...::..|....|.|:......||.
  Fly  2960 EDYGKDLAAVSNLLKKHERLEAD-VAHHGELADQLKQKDEQFFQAEHFLRHEIHERATVSIRRYN 3023

  Fly  1728 RICNLAAHRQARLNEALTLHQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAE 1792
            .:......|:..|.::|:|.||.||..||..|:.||:|:.||.|.|..|..||.|:|||..||||
  Fly  3024 TLHEPLGIRRENLEDSLSLQQFLRDAEDELQWLAEKQLVAGSQDLGTSLLSVQGLQKKHNSLEAE 3088

  Fly  1793 LGSHEPAIQAVQEAGEKLMDVSNLGVPEIEQRLKALNQAWAELKNLAATRGQKLDESLTYQQFLA 1857
            |.|.||.|||:.:.|::::..::....:::.:.:.|.:...:|::|||.|..:|.:::..|.|..
  Fly  3089 LTSQEPLIQALLQRGQQMIRDNHFASEQLQYKSELLQKQLVQLRDLAAIRRLRLLDAVESQLFYV 3153

  Fly  1858 QVEEEEAWITEKQQLLSVEDYGDSMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSELVEAKNH 1922
            :..|.:||:.||:.:||..|||....:|||..||.:..:.:.||.|.....:....:.|:|..:.
  Fly  3154 EANEADAWMREKRPVLSSSDYGRDEVSVQGHQKKLEVLQRELTAFKPSIEKVAKLATGLIERNHF 3218

  Fly  1923 HGESIAQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFMWKADVVESWIDDKENYVRSDEFGRD 1987
            ...:||::..|:..:.::|..||..|:..|.:.....:::.:.:.:..|:.|:.....|:::|.|
  Fly  3219 DSSNIAEKNAQVGQEYEDLLRLAKERESRLGECKKLFEYLRETEELHEWVGDQMAVTASEDYGED 3283

  Fly  1988 LSTVQTLLTKQETFDAGLNAFEQEGIHNITALKDQLINASHAQSPAILKRHGDVIARWQKLRDAS 2052
            :..|:.|:...|:|.:.|||.|.. :.......|:||..::....:|..:..:....|::|:|..
  Fly  3284 VEHVEQLILAFESFVSNLNANEAR-VEACLERGDRLIQENNPYRSSIKSKRDETKQLWEELKDLV 3347

  Fly  2053 NTRKDRLLAMQE--QFRQI--EELYLTFAKKASAFNSWFENAEEDLTDPVRCNSIEEIRALRDAH 2113
            :.|:|.|...::  .:.::  |.:.|...|.||..:   |:..:||         |.|:||...|
  Fly  3348 HARQDALAGAKQVHVYDRVADETIQLINEKDASLIS---EDYGQDL---------ESIQALGRKH 3400

  Fly  2114 AQFQASLSSAEADFKALAALDQKIKSFNVGPNPYTWFTMEALEETWRNLQKIIEERDGELAKEAK 2178
            ..|::.|...:....::.|...|:.........:.....:...|.|.:|::....|..:|::..:
  Fly  3401 QVFESELVGIQGQVDSVLAEAAKLGEIYPDAKEHIEVKRDETVEAWTDLKEKTAARKNKLSQAEQ 3465

  Fly  2179 RQEENDKLRKEFAKHANLFHQWLTETRYYMLGYNRQGTSMMEGSGSLEQQLEALRVKATEVRARR 2243
            .|...|:.|...|        |:.|    ||. ......:.......|..|.:.:...||:|.|.
  Fly  3466 LQSYFDEYRDLIA--------WINE----MLA-KITAPELANSVAGAELLLASTKDHDTEIRTRD 3517

  Fly  2244 VDLKKIEELGALL--EEHL----------ILDNRY--TEHSTVGLAQQWDQLD---QLSMRMQHN 2291
            ....|....|..|  |:|.          :|..|:  .:| |:...::..:|:   ||.::....
  Fly  3518 ETFAKFAANGQQLIKEKHFLAHEVEDKIKVLQARHELLKH-TLNKRREIYELNLDTQLFLKDAEI 3581

  Fly  2292 LEQQIQARNHSGVSEDSLKEF----------SMMFKHFDKDKSGKLNHQEFKSCLRALGYDLPMV 2346
            |||.|.:|      |..||:.          .::.:|.|.:|:.....::|::..|     :.|:
  Fly  3582 LEQWISSR------EPQLKDTKLGDSIPQVEDLLRRHEDFEKTVAAQEEKFQAIKR-----ITML 3635

  Fly  2347 EE 2348
            |:
  Fly  3636 EQ 3637

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 18/212 (8%)
SPEC 1074..1287 CDD:238103 78/243 (32%)
SPEC 1182..1425 CDD:238103 65/244 (27%)
SPEC 1426..1638 CDD:238103 78/211 (37%)
SPEC 1533..1744 CDD:238103 79/211 (37%)
SPEC 1646..1850 CDD:238103 77/204 (38%)
SPEC 1852..2062 CDD:238103 53/209 (25%)
SPEC 1958..2176 CDD:238103 45/221 (20%)
SPEC 2072..2296 CDD:238103 50/240 (21%)
EFh 2311..2379 CDD:238008 7/48 (15%)
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103 63/371 (17%)
SPEC 154..364 CDD:238103 65/209 (31%)
SPEC 261..470 CDD:238103 57/211 (27%)
SPEC 471..680 CDD:238103 77/208 (37%)
SPEC 682..893 CDD:238103 58/210 (28%)
Spectrin 893..>961 CDD:395348 28/173 (16%)
kstNP_001097492.2 CH 76..178 CDD:237981
CH 197..303 CDD:237981
SPEC 450..640 CDD:238103
SPEC 658..832 CDD:238103 28/99 (28%)
SH3 885..935 CDD:214620 0/49 (0%)
SPEC 1030..1236 CDD:238103 65/209 (31%)
SPEC 1134..1341 CDD:238103 56/210 (27%)
SPEC 1343..1551 CDD:238103 77/208 (37%)
SPEC 1449..1658 CDD:238103 63/209 (30%)
SPEC 1555..1764 CDD:238103 57/208 (27%)
SPEC 1765..1975 CDD:238103 30/209 (14%)
SPEC 1873..2080 CDD:238103 16/206 (8%)
SPEC 1979..2185 CDD:238103 18/205 (9%)
SPEC 2188..2402 CDD:238103 29/213 (14%)
SPEC 2407..2618 CDD:238103 71/212 (33%)
SPEC 2514..2725 CDD:238103 64/242 (26%)
SPEC 2726..2934 CDD:238103 78/211 (37%)
SPEC 2935..3145 CDD:238103 77/210 (37%)
SPEC 3042..3251 CDD:238103 71/208 (34%)
SPEC 3149..3357 CDD:238103 53/208 (25%)
SPEC 3359..3567 CDD:238103 45/233 (19%)
SPEC 3465..3680 CDD:238103 41/198 (21%)
PH 3799..3902 CDD:278594
PH_beta_spectrin 3801..3904 CDD:269975
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439925
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1400at33392
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.750

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