DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alpha-Spec and actn3b

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_991107.2 Gene:actn3b / 323320 ZFINID:ZDB-GENE-030131-2040 Length:898 Species:Danio rerio


Alignment Length:1075 Identity:251/1075 - (23%)
Similarity:448/1075 - (41%) Gaps:301/1075 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1484 LQTVADQLIAQNHYASNLV-----DEKRKQVLERW--RHLKEGLIEKRSRLGDEQTLQQFSRDAD 1541
            :.|..|.:|.::.:..:|:     ::::::....|  .||:        :.|     .|.....:
Zfish    17 MSTTQDYMIQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLR--------KAG-----TQIENIEE 68

  Fly  1542 EIENWIAEKLQLATEESYKDPANIQSKHQKHQAFEAELAANADR-IQSVLAMGGNLIDKKQCSGS 1605
            :..|.:...|.|......:.|...:.|.:.|:      .||.:: :..:.:.|..|:.    .|:
Zfish    69 DFRNGLKLMLLLEVISGERLPKPDKGKMRFHK------IANVNKALDFICSKGVKLVS----IGA 123

  Fly  1606 ED--------------------AVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDL 1650
            |:                    |:|....:.....|.|......|:...:..|.|..:|:     
Zfish   124 EEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHIS----- 183

  Fly  1651 DFWLGEVESLLTTEDSGKDLASVQNLMKKHQ--LVEADIVAHEDRIKDMNN-------------- 1699
              |              ||..::..|:.:|:  |::...:..:|.|.::|.              
Zfish   184 --W--------------KDGLALCALIHRHRPDLIDYSKLRKDDPIGNLNTAFEVAEKYLDIPKM 232

  Fly  1700 -QADSLVESGQFDT--------------AGIQEKRQSINERYERICNLAAHRQARLNEALTLHQF 1749
             .|:.:|.:.:.|.              ||.::...:.|    |||.:.|..|.  ||.| :.::
Zfish   233 LDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAAN----RICKVLAVNQE--NERL-MEEY 290

  Fly  1750 FRDIADEESWIK------------------EKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELG-- 1794
            .:..::...||:                  ::||    :|: ||...|....:..::.:.|:.  
Zfish   291 EKLASELLEWIRRTIPWLENRAAEQTMRAMQQKL----EDF-RDYRRVHKPPRVQEKCQLEINFN 350

  Fly  1795 --------SHEPAIQAVQEAGEKLMDVSNL--GVPEIEQRLKALNQAW--AELKNLAATRGQKLD 1847
                    |:.||.  :...|:.:.|::|.  |:.::|:..    :.|  .|::.|     ::||
Zfish   351 TLQTKLRLSNRPAF--MPSEGKMVSDIANAWKGLEQVEKGY----EEWLLTEIRRL-----ERLD 404

  Fly  1848 ESLTYQQFLAQVEEEEAWITEKQQLLSVEDYGD-SMAAVQGLLKKHDAFETDFTAHKDRCSLICD 1911
            .  ..::|..:....|:|.|.|:.|||.:||.. |:..::.|::||:|||:|..||:||...|..
Zfish   405 H--LAEKFKQKCSLHESWTTGKEHLLSQKDYETASLMEIRALMRKHEAFESDLAAHQDRVEQIAA 467

  Fly  1912 QGSELVEAKNHHGESIAQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFMWKADVVESWIDDKE 1976
            ...||.|...|...::..|||.:..:.|||..|..:|:                           
Zfish   468 IAQELNELDYHDAATVNARCQGICDQWDNLGTLTQKRR--------------------------- 505

  Fly  1977 NYVRSDEFGRDLSTVQTLLTKQETFDAGLNAFEQEGIHNITALKDQLINASHAQSPAILKRHGDV 2041
                                                                           |.
Zfish   506 ---------------------------------------------------------------DS 507

  Fly  2042 IARWQKLRDASNTRKDRLLAMQEQFRQIEELYLTFAKKASAFNSWFENAEEDLTDPVRCNSIEEI 2106
            :.|.:||                 :..|::|||.|||:|:.||:|.:.|.|||.|....:|||||
Zfish   508 LERVEKL-----------------WETIDQLYLEFAKRAAPFNNWMDGAIEDLQDMFIVHSIEEI 555

  Fly  2107 RALRDAHAQFQASLSSAEADFKALAALDQKIKSFN-------VGPNPYTWFTMEALEETWRNLQK 2164
            ::|..||.||:|:|..|:.:..|:..:..:|....       ||.|||:..:.:.:...|..:::
Zfish   556 QSLITAHDQFKATLPEADKERMAVMGIQNEIVKIAQTYGIKLVGVNPYSVLSPQDITNKWEAVKQ 620

  Fly  2165 IIEERDGELAKEAKRQEENDKLRKEFAKHANLFHQWLTETRYYMLGYNRQGTSMMEGSGSLEQQL 2229
            ::..||..|.:|..||:.|::||:.||..||:...|: :|:...:|:     ..::.:||||:|:
Zfish   621 LVPLRDQMLQEEVARQQANERLRRSFAAQANIIGPWI-QTKMEEIGH-----VSVDIAGSLEEQM 679

  Fly  2230 EALRVKATEVRARRVDLKKIEELGALLEEHLILDNRYT----EHSTVGLAQQWDQLDQLSMRMQH 2290
            ..|:.....:...:.::.|:|....|::|.||.||::|    ||..||    |:||.....|..:
Zfish   680 NNLKQYEQNIINYKSNIDKLEGDHQLIQEALIFDNKHTNYTMEHIRVG----WEQLLTTIARTIN 740

  Fly  2291 NLEQQIQARNHSGVSEDSLKEFSMMFKHFDKDKSGKLNHQEFKSCLRALGYDLPMVEEGQPDPEF 2355
            .:|.||..|:..|:|::.|.||...|.|||:.::|.::..:|::||.::||||..|       ||
Zfish   741 EVENQILTRDAKGISQEQLNEFRASFNHFDRKRNGMMDPDDFRACLISMGYDLGEV-------EF 798

  Fly  2356 EAILDVVDPNRDGYVSLQEYIAFMISKETENVQSYEEIENAFRAITAADRPYVTKEELYCNLTKD 2420
            ..|:.:||||..|.|:.|.:|.|| ::||....:.|::..:|: |.|:|:||:|.|||...|..:
Zfish   799 ARIMTLVDPNNTGVVTFQAFIDFM-TRETAETDTAEQVMASFK-ILASDKPYITVEELRRELPPE 861

  Fly  2421 MADYCVQRMKPFSEPRSGQPIKDALDYIDFTRTLF 2455
            .|:||:.||..:..|...   ..|||||.|:..|:
Zfish   862 QAEYCISRMTKYVGPEGA---LGALDYISFSSALY 893

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742
SPEC 1074..1287 CDD:238103
SPEC 1182..1425 CDD:238103
SPEC 1426..1638 CDD:238103 26/181 (14%)
SPEC 1533..1744 CDD:238103 43/262 (16%)
SPEC 1646..1850 CDD:238103 45/266 (17%)
SPEC 1852..2062 CDD:238103 39/210 (19%)
SPEC 1958..2176 CDD:238103 44/224 (20%)
SPEC 2072..2296 CDD:238103 76/234 (32%)
EFh 2311..2379 CDD:238008 26/67 (39%)
EFhand_Ca_insen 2386..2456 CDD:400872 25/70 (36%)
SPEC 48..258 CDD:238103
SPEC 154..364 CDD:238103
SPEC 261..470 CDD:238103
SPEC 471..680 CDD:238103
SPEC 682..893 CDD:238103
Spectrin 893..>961 CDD:395348
actn3bNP_991107.2 SAC6 40..>404 CDD:227401 68/430 (16%)
SPEC 406..633 CDD:238103 79/333 (24%)
Spectrin 641..744 CDD:306853 32/112 (29%)
EFh_PEF 754..864 CDD:330173 44/118 (37%)
EFhand_Ca_insen 828..894 CDD:312305 25/70 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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