DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alpha-Spec and Sptb

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:XP_006240306.1 Gene:Sptb / 314251 RGDID:1303243 Length:2329 Species:Rattus norvegicus


Alignment Length:1784 Identity:474/1784 - (26%)
Similarity:815/1784 - (45%) Gaps:269/1784 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 KILETVED-----------IQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWI 63
            :|.:..||           |:.|.::|.::::..|.....:::.|:|:..|..|:.|||:|::|:
  Rat   695 QIFQEAEDMVAQKQFGHPQIETRVKEVSAQWDHLKELAAFRKKDLQDAENFFQFQGDADDLKAWL 759

  Fly    64 HEKLQAAS-EESYRDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRL 127
            .:..:..| |:..:|....:|..:||:.|..|:......:..|:|..|. ..::...|..:..||
  Rat   760 QDAHRLLSGEDVGQDEGATRALGKKHKEFLEELEESRGVMEHLENQAQG-FPEEFRDSPDVTNRL 823

  Fly   128 DELHKLWELLLSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQR 192
            ..|.||::.::::...:|.|||:||.|.....:.:....|:.:|..::...:....||.:||:|.
  Rat   824 QALRKLYQQVMAQAELRGHKLQEALDLYTVFGESDACELWMTEKGKWLDQMDIPNTLEDLEVVQH 888

  Fly   193 KFDEFQKDMASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGA 257
            :||...::|.:...::..||..|:.||:.|||....:.:.::.||:.||..:.:...::|.:..|
  Rat   889 RFDILDQEMKTLMAQIDGVNLAANNLVESGHPRSGEVKQYQDRLNKRWQAFQAVVSEQREAVDSA 953

  Fly   258 HEIQRFNRDADETVAWIAEK-DVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEA 321
            ..:..:..|.:||..||.:| .||.|:.|.|:|||.|.|:|||..|:|||:.|:.|:||.|..|:
  Rat   954 LRVNNYCVDCEETSKWIVDKTKVVESTKDLGQDLAGVIAIQRKLSGLERDVLAIRDRVSALERES 1018

  Fly   322 QRLCSIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAI 386
            |.|...|.|..:.|..:||::...|:.|....:.::..|.|:..|..||.|..|..:|::..:..
  Rat  1019 QYLMESHPDQKEDIGQRQADVEKMWKGLQDALQGQELSLGEASKLQAFLQDLDDFKAWLSMAQKA 1083

  Fly   387 ISADELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLERE---HYAAAEIQEKLAAL 448
            ::::::.:.:..||.||::|...|.||||.:|.:.....||:|::|.:   .|..  :.::|..|
  Rat  1084 VASEDMPESLPEAEQLLQQHAAIKEEIDAHKDDYHRVKASGEKVIEGQTDPDYQL--LGQRLEGL 1146

  Fly   449 ENDKSSLLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHE 513
            :.|..:|..:||.|.....||:..|.|.:|.:||:..::.||..||:.:..|||.:.||.|:|.|
  Rat  1147 DTDWDALWRMWESRGNTLTQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLAAAEAGIRKFE 1211

  Fly   514 DFEKSLAAQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRY 578
            ||..|:....:|:.:.......|:...:..::.:.::.|::..|.....||:.:...||:|:...
  Rat  1212 DFLVSMENNRDKVLSPVDSGNMLVSEGNLYSNKIKEKVQLIEDRHMKNNEKAQEVTALLKDNLEL 1276

  Fly   579 QQFERDCDETKGWISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIE 643
            |.|.::|.|...||::||..:.|.||.:..||:.|..|||.|..||.:::..:|:|...|.:|:.
  Rat  1277 QNFLQNCKELTLWINDKLLTSPDISYDEARNLHNKWMKHQAFMAELASHQGWLENIVAEGRQLMA 1341

  Fly   644 KQHYAADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSED 708
            ::....|.::.|::.:..||:.|...:..|..:|:.|.......:|..|:..|:|.:|.||.|:|
  Rat  1342 EKPQFTDVVSERLEALHKLWDELQTTTKAKTEQLSAARSSDLRLQTHADLSKWISAMEDQLRSDD 1406

  Fly   709 HGKDLTSVQNLQKKHALLEADVMAHQDRIESIKVAANKF-IESGHFDADNIRNKEGNLSARYAAL 772
            .|||||:|..:..|...:|..|...::.:|.:...|... .|:|..|.        ::..|:..|
  Rat  1407 LGKDLTTVNRMLVKLKRVEEQVNLRKEELEELFAEAPPLGAEAGDTDM--------SIEKRFLDL 1463

  Fly   773 AAPMGERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEIN 837
            ..|:|.||:.|..|....|:.||||||..|:.|:.|:|.|.:.|.:|..||..:||:|.:..||.
  Rat  1464 LEPLGRRKKQLELSKAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEIL 1528

  Fly   838 NHEARLLNVISSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADA 902
            .|..|:.:|:..|:.::|.......||.:||..||..|:||:|.::.|.|.|.::.:|.||:.||
  Rat  1529 GHAPRVEDVLHRGQELVKAAEIDCQDIEERLGHLQSSWDTLREAAAGRLQRLREAHEAQQYYLDA 1593

  Fly   903 NEAESWMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETPVV 967
            .|||:|:.|:|......:..|||:.:..:||:|                       .|||.|   
  Rat  1594 GEAEAWISEQELYVFSDEPPKDEEGAIVMLKRH-----------------------LRQQRT--- 1632

  Fly   968 DITGKECVVALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLS 1032
                          .|:..|.:....|...:||::.:.                           
  Rat  1633 --------------VEEYGRNIKQLAGRAQSLLSAGHP--------------------------- 1656

  Fly  1033 ASQQNLVDNHSIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQ 1097
                   :...|.:.|.|::.||..|..:|.||:.||......:.|.|||.||.|||.:||..|.
  Rat  1657 -------EGEQIIRLQGQVDKQYAGLKDMAEERRRKLENMYHLFQLKREADDLEQWITEKEMVAS 1714

  Fly  1098 IADVVGEDLEEVEVLQKKFDDFNDDLKA-NEVRLANMNEIAVQLTSLGQTEAALKIQTQMQDLNE 1161
             :..:|:|.:.|.:|:.||.||..:..| .:.|:.|:|.|..:|...|.:||| .|......||:
  Rat  1715 -SQEMGQDFDHVTMLRDKFRDFARETGAIGQERVDNVNSIIERLIDAGHSEAA-TIAEWKDGLND 1777

  Fly  1162 KWNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGV 1226
            .|.:|..|...:...|.:::::.|:.....|....|.||...| .:|:|.|..:.::..|.|...
  Rat  1778 MWADLLELIDTRMQLLAASYDLHRYFYTGTEILGLIDEKHREL-PEDVGLDASTAESFHRVHTAF 1841

  Fly  1227 ERDLAALRDKIRQLDETANRLMQSHP-DTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQ 1290
            ||:|..|..:::|..:.|.||..::. :.|:...:|::|::..|..::.....|:.:|:|:.|..
  Rat  1842 ERELHLLGVQVQQFQDVATRLQTAYAGEKADAIQSKEQEVSAAWQALLDACAGRRAQLVDTADKF 1906

  Fly  1291 RFLSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAASTSSI 1355
            ||.|..||||:|:.|::..:.:.|...||:..|.|::.||..:|                     
  Rat  1907 RFFSMVRDLLSWMESIIRQIETQERPRDVSSVELLLKYHQGIKA--------------------- 1950

  Fly  1356 ASPSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQ 1420
                       ||:.||..|....:.|..|||..|.||.||:||::.:...|:::...|..|..:
  Rat  1951 -----------EINTRAKNFSTCLELGESLLQRQHQASDEIREKLQQVISRRQEMNDKWEARSDR 2004

  Fly  1421 LEQNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQ 1485
            |...|::..:.||..:||:|:.|:|.:|.:.|..:...:||.|||:||.|:|:.....::.|||:
  Rat  2005 LHMLLEVCQFSRDASVAEAWLIAQEPYLASRDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALE 2069

  Fly  1486 ---------------------------TVADQLIAQNHYASNLV--------------------- 1502
                                       ..|.:....:|.|:...                     
  Rat  2070 KPTTLELKERQTPDRPTEEPGPQEEEGETAGEAPQVHHAATERTSPGEERGPWPQDLQPPPLPGH 2134

  Fly  1503 --DEKRKQVLERWRHLKEGL---IEKRSRLGDEQTLQQFSRDAD---EIENWIAEKLQL------ 1553
              ||:.|.|.:. |...|.|   ::.....|||.|.....||..   ::|.::..|..|      
  Rat  2135 HKDEQEKSVGDE-RPATEPLFKVLDTPLSEGDEPTTLPAQRDLGHTVQMEGYLGRKHDLEGPNKK 2198

  Fly  1554 ATEES---------------YKDPANIQSKHQKHQAFEAELAANADRIQSVLAMGGNLIDKKQCS 1603
            |:..|               |||..|                         ||:|      ....
  Rat  2199 ASNRSWNNLYCVLRNSQLTFYKDAKN-------------------------LALG------VPYH 2232

  Fly  1604 GSED-AVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFWL----GEVESLLTT 1663
            |.|. |::..:.:||     :.:|..:...||:.:|...           ||    .|.|.||..
  Rat  2233 GEEPLALRHAICEIA-----VNYKKKKHVFKLRLSNGSE-----------WLFHGKDEEEMLLWL 2281

  Fly  1664 EDSGKDLASVQNLMKKHQLVEADIVAHED 1692
            :.....:...|::..|.|.:....:|..|
  Rat  2282 QGMSTAINESQSIRVKAQSLPLPSLAGPD 2310

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 5/51 (10%)
SPEC 1074..1287 CDD:238103 63/214 (29%)
SPEC 1182..1425 CDD:238103 64/243 (26%)
SPEC 1426..1638 CDD:238103 57/289 (20%)
SPEC 1533..1744 CDD:238103 34/189 (18%)
SPEC 1646..1850 CDD:238103 11/51 (22%)
SPEC 1852..2062 CDD:238103
SPEC 1958..2176 CDD:238103
SPEC 2072..2296 CDD:238103
EFh 2311..2379 CDD:238008
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103 54/210 (26%)
SPEC 154..364 CDD:238103 65/210 (31%)
SPEC 261..470 CDD:238103 70/212 (33%)
SPEC 471..680 CDD:238103 60/208 (29%)
SPEC 682..893 CDD:238103 70/211 (33%)
Spectrin 893..>961 CDD:395348 17/67 (25%)
SptbXP_006240306.1 CH_SPTB-like_rpt1 40..156 CDD:409095
CH_SPTB_rpt2 170..281 CDD:409168
Spectrin 302..411 CDD:395348
Spectrin 422..526 CDD:395348
SPEC 530..742 CDD:238103 8/46 (17%)
SPEC 641..848 CDD:238103 37/153 (24%)
SPEC 745..954 CDD:238103 54/209 (26%)
SPEC 962..1168 CDD:238103 70/207 (34%)
SPEC 1170..1379 CDD:238103 60/208 (29%)
SPEC 1385..1475 CDD:197544 29/97 (30%)
SPEC 1485..1690 CDD:238103 75/278 (27%)
SPEC 1691..1901 CDD:238103 62/212 (29%)
SPEC 1798..2005 CDD:238103 63/239 (26%)
SPEC 2013..>2086 CDD:197544 21/72 (29%)
PH_beta_spectrin 2182..2287 CDD:269975 27/151 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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