Protein Alignment alpha-Spec and Actn

DIOPT Version :10

• Sequence 1: NP_001261286.1
• Gene: alpha-Spec / 38231
• FlyBaseID: FBgn0250789
• Length: 2457
• Species: Drosophila melanogaster
• Sequence 2: NP_477485.1
• Gene: Actn / 31166
• FlyBaseID: FBgn0000667
• Length: 917
• Species: Drosophila melanogaster
• Alignment Length: 1061
• Identity: 262/1061 - (24%)
• Similarity: 434/1061 - (40%)
• Gaps: 284/1061 - (26%)

  Fly  1511 ERWRHLKEGLIEKRSRLGDEQT--------LQQFSRDADEIENWIAE--KLQLATE----ESYKD 1561
            |.|.  :|||::.......::|        |::.....|.||.....  ||.|..|    |:...
  Fly    20 EEWE--REGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPK 82

  Fly  1562 PANIQSKHQKHQAFEAELAANADR-IQSVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQ-W---- 1620
            |...:.:..|        .||.:: :..:.:.|.:|:.    .|:|:.|...|...... |
  Fly    83 PDRGKMRFHK--------IANVNKALDFIASKGVHLVS----IGAEEIVDGNLKMTLGMIWTIIL 135

  Fly  1621 ---------EYLTHK------TTEKSLKLKEANKQRTYIAAVKDLDFWL---------------- 1654
                     |.:|.|      ...|:...|..|.|..:::....|.|..
  Fly   136 RFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLS 200

  Fly  1655 --GEVESLLTTEDSGKDLASVQNLMKKHQLVE----------------------ADIVAHEDRIK 1695
              ..:|:|.|..|..:....:..::....|:.                      |..|.:...:.
  Fly   201 KDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVP 265

  Fly  1696 DMNNQADSLVESGQFDTAGIQEKRQSINERYERICNLAAHRQARLNEALTLHQFFRDIADEESWI 1760
            :...|...:..:...:||.            .|||.:....|.  ||.| :.::.|..:|...||
  Fly   266 EPTRQYTYVPNNYNAETAA------------NRICKVLKVNQE--NERL-MEEYERLASDLLEWI 315

  Fly  1761 KEKKLLVGSDDYGRDLTGVQ-------NLKKKHK--------RLEAELG--------SHEPAIQA 1802
            :.....:.|......|.|||       ..::|||        :||....        |:.||...
  Fly   316 RRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLP 380

  Fly  1803 VQEAGEKLMDVSN------LGVPEIEQRLKALNQAWAELKNLAATRGQKLDESLTYQQFLAQVEE 1861
            .:  |:.:.|:||      |.....|:.|.|.......|::||             |:|..:.:.
  Fly   381 TE--GKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLA-------------QKFKHKADA 430

  Fly  1862 EEAWITEKQQLLSVEDYGD-SMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSELVEAKNHHGE 1925
            .|.|...|:::|..:|:.. .:..::.|.|||:|||:|..||:||...|.....||...:.|...
  Fly   431 HEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCV 495

  Fly  1926 SIAQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFMWKADVVESWIDDKENYVRSDEFGRDLST 1990
            |:..|||::..:.|.|.||..||:.||                             ||
  Fly   496 SVNARCQRICDQWDRLGALTQRRRTAL-----------------------------DE------- 524

  Fly  1991 VQTLLTKQETFDAGLNAFEQEGIHNITALKDQLINASHAQSPAILKRHGDVIARWQKLRDASNTR 2055
                                                                             
  Fly   525 ----------------------------------------------------------------- 524

  Fly  2056 KDRLLAMQEQFRQIEELYLTFAKKASAFNSWFENAEEDLTDPVRCNSIEEIRALRDAHAQFQASL 2120
            .:|:|      .:|:.|:|.|||:|:.||:|.:...|||.|....:::|||:.|..||.||:|:|
  Fly   525 AERIL------EKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATL 583

  Fly  2121 SSAEADFKALAALDQKIKSF---NVGP----NPYTWFTMEALEETWRNLQKIIEERDGELAKEAK 2178
            ..|:.:|..:..|.::::|.   :..|    ||||..|...:...|.::::::.:||..||.|.:
  Fly   584 GEADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELR 648

  Fly  2179 RQEENDKLRKEFAKHANLFHQWLTETRYYMLGYNRQGTSM----MEGSGSLEQQLEALRVKATEV 2239
            :|:.|:.||::||:.||:...|:          .||..::    |...||||.||..|:.....|
  Fly   649 KQQNNEMLRRQFAEKANIVGPWI----------ERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAV 703

  Fly  2240 RARRVDLKKIEELGALLEEHLILDNRYTEHSTVGLAQQWDQLDQLSMRMQHNLEQQIQARNHSGV 2304
            .|.:.:::::|::...::|.:|.:||||.::...|...|:||.....|..:.:|.||..|:..|:
  Fly   704 YAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGI 768

  Fly  2305 SEDSLKEFSMMFKHFDKDKSGKLNHQEFKSCLRALGYDLPMVEEGQPDPEFEAILDVVDPNRDGY 2369
            |::.|.||...|.||||:::|:|:.:||||||.:|||.:.  ::.|.|.:|:.||.|||||..||
  Fly   769 SQEQLNEFRSSFNHFDKNRTGRLSPEEFKSCLVSLGYSIG--KDRQGDLDFQRILAVVDPNNTGY 831

  Fly  2370 VSLQEYIAFMISKETENVQSYEEIENAFRAITAADRPYVTKEELYCNLTKDMADYCVQRMKPFSE 2434
            |....::.|| ::|:.:..:.|::.::|| |.|||:||:..:||...|..|.|:||:|||.|:..
  Fly   832 VHFDAFLDFM-TRESTDTDTAEQVIDSFR-ILAADKPYILPDELRRELPPDQAEYCIQRMPPYKG 894

  Fly  2435 PRSGQPIKDALDYIDFTRTLF 2455
            | :|.|  .||||:.|:..|:
  Fly   895 P-NGVP--GALDYMSFSTALY 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Spec	NP_001261286.1	SPEC	48..258	CDD:238103
		SPEC	154..364	CDD:238103
		SPEC	261..470	CDD:238103
		SPEC	471..680	CDD:238103
		SPEC	682..893	CDD:238103
		Spectrin	893..>961	CDD:395348
		SH3_Alpha_Spectrin	974..1026	CDD:212742
		SPEC	1074..1287	CDD:238103
		SPEC	1182..1425	CDD:238103
		SPEC	1426..1638	CDD:238103	31/161 (19%)
		SPEC	1533..1744	CDD:238103	45/277 (16%)
		SPEC	1646..1850	CDD:238103	47/272 (17%)
		SPEC	1852..2062	CDD:238103	39/210 (19%)
		SPEC	1958..2176	CDD:238103	43/224 (19%)
		SPEC	2072..2296	CDD:238103	73/234 (31%)
		EFh	2311..2379	CDD:238008	31/67 (46%)
		EFhand_Ca_insen	2386..2456	CDD:430177	29/70 (41%)
Actn	NP_477485.1	CH_ACTN_rpt1	31..135	CDD:409063	21/115 (18%)
		CH_ACTN_rpt2	139..252	CDD:409065	14/112 (13%)
		SPEC	302..525	CDD:238103	65/338 (19%)
		SPEC	420..647	CDD:238103	80/346 (23%)
		SPEC	538..760	CDD:238103	71/231 (31%)
		EFh	775..842	CDD:238008	33/69 (48%)
		EFhand_Ca_insen	847..913	CDD:430177	29/70 (41%)