DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alpha-Spec and Actn

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_001259165.1 Gene:Actn / 31166 FlyBaseID:FBgn0000667 Length:917 Species:Drosophila melanogaster


Alignment Length:1061 Identity:262/1061 - (24%)
Similarity:434/1061 - (40%) Gaps:284/1061 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  1511 ERWRHLKEGLIEKRSRLGDEQT--------LQQFSRDADEIENWIAE--KLQLATE----ESYKD 1561
            |.|.  :|||::.......::|        |::.....|.||.....  ||.|..|    |:...
  Fly    20 EEWE--REGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPK 82

  Fly  1562 PANIQSKHQKHQAFEAELAANADR-IQSVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQ-W---- 1620
            |...:.:..|        .||.:: :..:.:.|.:|:.    .|:|:.|...|...... |    
  Fly    83 PDRGKMRFHK--------IANVNKALDFIASKGVHLVS----IGAEEIVDGNLKMTLGMIWTIIL 135

  Fly  1621 ---------EYLTHK------TTEKSLKLKEANKQRTYIAAVKDLDFWL---------------- 1654
                     |.:|.|      ...|:...|..|.|..:::....|.|..                
  Fly   136 RFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLS 200

  Fly  1655 --GEVESLLTTEDSGKDLASVQNLMKKHQLVE----------------------ADIVAHEDRIK 1695
              ..:|:|.|..|..:....:..::....|:.                      |..|.:...:.
  Fly   201 KDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQVGNVTHVP 265

  Fly  1696 DMNNQADSLVESGQFDTAGIQEKRQSINERYERICNLAAHRQARLNEALTLHQFFRDIADEESWI 1760
            :...|...:..:...:||.            .|||.:....|.  ||.| :.::.|..:|...||
  Fly   266 EPTRQYTYVPNNYNAETAA------------NRICKVLKVNQE--NERL-MEEYERLASDLLEWI 315

  Fly  1761 KEKKLLVGSDDYGRDLTGVQ-------NLKKKHK--------RLEAELG--------SHEPAIQA 1802
            :.....:.|......|.|||       ..::|||        :||....        |:.||...
  Fly   316 RRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLP 380

  Fly  1803 VQEAGEKLMDVSN------LGVPEIEQRLKALNQAWAELKNLAATRGQKLDESLTYQQFLAQVEE 1861
            .:  |:.:.|:||      |.....|:.|.|.......|::||             |:|..:.:.
  Fly   381 TE--GKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLA-------------QKFKHKADA 430

  Fly  1862 EEAWITEKQQLLSVEDYGD-SMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSELVEAKNHHGE 1925
            .|.|...|:::|..:|:.. .:..::.|.|||:|||:|..||:||...|.....||...:.|...
  Fly   431 HEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCV 495

  Fly  1926 SIAQRCQQLRLKLDNLSALAARRKGALLDNSAYLQFMWKADVVESWIDDKENYVRSDEFGRDLST 1990
            |:..|||::..:.|.|.||..||:.||                             ||       
  Fly   496 SVNARCQRICDQWDRLGALTQRRRTAL-----------------------------DE------- 524

  Fly  1991 VQTLLTKQETFDAGLNAFEQEGIHNITALKDQLINASHAQSPAILKRHGDVIARWQKLRDASNTR 2055
                                                                             
  Fly   525 ----------------------------------------------------------------- 524

  Fly  2056 KDRLLAMQEQFRQIEELYLTFAKKASAFNSWFENAEEDLTDPVRCNSIEEIRALRDAHAQFQASL 2120
            .:|:|      .:|:.|:|.|||:|:.||:|.:...|||.|....:::|||:.|..||.||:|:|
  Fly   525 AERIL------EKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATL 583

  Fly  2121 SSAEADFKALAALDQKIKSF---NVGP----NPYTWFTMEALEETWRNLQKIIEERDGELAKEAK 2178
            ..|:.:|..:..|.::::|.   :..|    ||||..|...:...|.::::::.:||..||.|.:
  Fly   584 GEADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELR 648

  Fly  2179 RQEENDKLRKEFAKHANLFHQWLTETRYYMLGYNRQGTSM----MEGSGSLEQQLEALRVKATEV 2239
            :|:.|:.||::||:.||:...|:          .||..::    |...||||.||..|:.....|
  Fly   649 KQQNNEMLRRQFAEKANIVGPWI----------ERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAV 703

  Fly  2240 RARRVDLKKIEELGALLEEHLILDNRYTEHSTVGLAQQWDQLDQLSMRMQHNLEQQIQARNHSGV 2304
            .|.:.:::::|::...::|.:|.:||||.::...|...|:||.....|..:.:|.||..|:..|:
  Fly   704 YAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGI 768

  Fly  2305 SEDSLKEFSMMFKHFDKDKSGKLNHQEFKSCLRALGYDLPMVEEGQPDPEFEAILDVVDPNRDGY 2369
            |::.|.||...|.||||:::|:|:.:||||||.:|||.:.  ::.|.|.:|:.||.|||||..||
  Fly   769 SQEQLNEFRSSFNHFDKNRTGRLSPEEFKSCLVSLGYSIG--KDRQGDLDFQRILAVVDPNNTGY 831

  Fly  2370 VSLQEYIAFMISKETENVQSYEEIENAFRAITAADRPYVTKEELYCNLTKDMADYCVQRMKPFSE 2434
            |....::.|| ::|:.:..:.|::.::|| |.|||:||:..:||...|..|.|:||:|||.|:..
  Fly   832 VHFDAFLDFM-TRESTDTDTAEQVIDSFR-ILAADKPYILPDELRRELPPDQAEYCIQRMPPYKG 894

  Fly  2435 PRSGQPIKDALDYIDFTRTLF 2455
            | :|.|  .||||:.|:..|:
  Fly   895 P-NGVP--GALDYMSFSTALY 912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742
SPEC 1074..1287 CDD:238103
SPEC 1182..1425 CDD:238103
SPEC 1426..1638 CDD:238103 31/161 (19%)
SPEC 1533..1744 CDD:238103 45/277 (16%)
SPEC 1646..1850 CDD:238103 47/272 (17%)
SPEC 1852..2062 CDD:238103 39/210 (19%)
SPEC 1958..2176 CDD:238103 43/224 (19%)
SPEC 2072..2296 CDD:238103 73/234 (31%)
EFh 2311..2379 CDD:238008 31/67 (46%)
EFhand_Ca_insen 2386..2456 CDD:400872 29/70 (41%)
SPEC 48..258 CDD:238103
SPEC 154..364 CDD:238103
SPEC 261..470 CDD:238103
SPEC 471..680 CDD:238103
SPEC 682..893 CDD:238103
Spectrin 893..>961 CDD:395348
ActnNP_001259165.1 CH_ACTN_rpt1 31..135 CDD:409063 21/115 (18%)
CH_ACTN_rpt2 139..252 CDD:409065 14/112 (13%)
SPEC 302..525 CDD:238103 65/338 (19%)
SPEC 420..647 CDD:238103 80/346 (23%)
SPEC 538..760 CDD:238103 71/231 (31%)
EFh 775..842 CDD:238008 33/69 (48%)
EFhand_Ca_insen 847..913 CDD:400872 29/70 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439911
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR11915
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.950

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