DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Spec and Spta1

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_001011908.3 Gene:Spta1 / 289257 RGDID:1305194 Length:2415 Species:Rattus norvegicus


Alignment Length:2467 Identity:1108/2467 - (44%)
Similarity:1614/2467 - (65%) Gaps:68/2467 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 TPKEV-------KILETVEDIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESW 62
            ||||.       |:|||.|:||.||::||.:|..||....::.:|||:|..:|.|:||||:||.|
  Rat     3 TPKETAVESSGPKVLETAEEIQHRRQEVLDQYQRFKERVAERGQKLEESYHYQVFRRDADDLEKW 67

  Fly    63 IHEKLQAASEESYRDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRL 127
            |.|||:...:::| :|||:|.|.|||::|.:||.|.|..:..|:...:....:.|||.|:.:..|
  Rat    68 IMEKLEITKDKTY-EPTNIQGKYQKHESFVSEVQAKSRVLPELEEIREARFAEDHFAHEATKTHL 131

  Fly   128 DELHKLWELLLSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQR 192
            .||..||:|||....||...|.:||...|:.::||:::.|:|:||..||..|.|.|.|..|||.:
  Rat   132 KELRHLWDLLLELTQEKSDILLRALKFYQYCQECEDILEWVKEKEAIVTLVELGDDWERTEVLHK 196

  Fly   193 KFDEFQKDMASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGA 257
            ||:|||:::.:::.:|..|||.|::..|:.||:...|..:::|:|.||.||..||:.|:|.|..|
  Rat   197 KFEEFQEELTARKGKVDRVNQYANECAQEQHPKLPEIKAKQDEVNAAWDRLWSLALKRRESLSNA 261

  Fly   258 HEIQRFNRDADETVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQ 322
            .::|||.||.:|.:.|:.||:.:|:|:|||:||.|.:||...|:.:||:||.::|||..|.|:|.
  Rat   262 ADLQRFKRDVNEAIQWMEEKEPLLTSEDYGKDLVSSEALFHSHKRLERNLAVMDDKVKELCAKAD 326

  Fly   323 RLCSIHADHSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAII 387
            :|...|:..:.||:..:.::.:.|:.:...|..|..||..||..||||:|:.:|..|:....|:|
  Rat   327 KLMVSHSADAPQIQQMKMDLVSNWELIRALATNRYAKLKASYGYHRFLSDYDELTGWMEEKTALI 391

  Fly   388 SADELAKDVAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREHYAAAEIQEKLAALENDK 452
            :||||..|||..||||.|||:||.|||:.:|.|:....:||.||:..|.|:.||:||:..|.:|.
  Rat   392 NADELPTDVASGEALLARHQQHKHEIDSYDDRFQTAEATGQDLLDGNHEASDEIREKMTILAHDW 456

  Fly   453 SSLLSLWEDRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEK 517
            ::|..||...:..|.|.:|..|||||:||.|:||::|||||.|||||:|:.|||||::||:|||:
  Rat   457 AALRELWNKCQHQYRQSLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSVGSVEALLQKHDDFEE 521

  Fly   518 SLAAQEEKIKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFE 582
            :..||||||..||..||||||..||.::::|..|..|||||.||:|:::.||:||.||...||..
  Rat   522 AFTAQEEKIITLDETATKLIDNDHYDSENIAAIRDGLLARRDALRERAATRRKLLVDSQLLQQLY 586

  Fly   583 RDCDETKGWISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHY 647
            :|.|:.|.||::|.|.|.|:.|.|..||..::||.|:||.||.||:..:.::...|.::||..||
  Rat   587 QDSDDLKTWINKKKKLADDEDYKDVQNLKSRVQKQQDFEEELAANEIMLNNLERTGQDMIENDHY 651

  Fly   648 AADQINTRMQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKD 712
            |:|.:..||.|:..||:.|::|:.:|||:|.||.|..||....||::.||.|:|.|:.|||:||.
  Rat   652 ASDAVAARMSEVANLWKELLEATAQKGTQLYEANQLLQFENNAEDLKRWLEEVERQVASEDYGKG 716

  Fly   713 LTSVQNLQKKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAPMG 777
            |..||||.:||.|||:.|:|.||:::::...|..|.|.||.|::||..::.:|.:|:.||..|:.
  Rat   717 LADVQNLLRKHGLLESAVLARQDQVDTLTDMAAHFEEIGHPDSENICARQESLLSRFEALKEPLA 781

  Fly   778 ERKQHLLDSLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEAR 842
            .||:.|:|.|::||:.||.|||.|||:|.||.||||:.|:||:..:||:.:|:.:||:|.:||.|
  Rat   782 TRKKKLIDLLKLQQICRDSEDEEAWIQETEPSAASTHLGKDLVAAKNLLNRHEVILADIASHEPR 846

  Fly   843 LLNVISSGENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEAES 907
            :..:...|..|:::..|||:||..|:|:|.:...:|:.::.:|:.||..::|..||.||.:|||:
  Rat   847 IQTITERGNKMVEEGHFASEDIASRVESLNKNMESLRARAIRRENDLKANVQLQQYLADLHEAEA 911

  Fly   908 WMREKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETPVVDITGK 972
            |::|||||....:||.||:::.||||||||.:.||.||||:|:||.:||:.|:||:...||..|:
  Rat   912 WIKEKEPIVDNKNYGADEEAAGALLKKHEAFLVDLNAFGNSIKALGDQAEACQQQQAAPVDEAGR 976

  Fly   973 EC-VVALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKI--DAGLSAS 1034
            |. |:||||:..:|.|||||||.||||||:|.||||||||.:|.||||||.|::|:  |......
  Rat   977 EARVIALYDFEARSRREVSMKKNDVLTLLSSINKDWWKVEADDHQGFVPAVYVRKLAHDELPGFP 1041

  Fly  1035 QQNLVDNHSIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQIA 1099
            ||...:..:|.:.|.||.:.|.:||..|.||:.:|.:....::|..||.|:.:||::|:     .
  Rat  1042 QQRREEPVNIPQLQEQIETLYHSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK-----T 1101

  Fly  1100 DVVGEDLEEVEVLQKKFDDFNDDLKANEVRLANMNEIAVQLTSLGQTEAALKIQTQ--MQDLNEK 1162
            :..|.:|::|..||||||:|..|||:||.||.::|::|.:|.    .|..|..:..  .|:||.:
  Rat  1102 ENTGVELDDVWELQKKFDEFQRDLKSNEPRLKDINKVADELL----FEDLLTPEGSHIRQELNTR 1162

  Fly  1163 WNNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVE 1227
            |::|:.|..|:...|.|||.|:.|.|:.|:.|:.|.:|..|||..|.|.||.|||.|||:||..|
  Rat  1163 WSSLKRLADEQYQLLSSAHAVEMFLREADDVKEQIDKKCQALNAADPGSDLLSVQALQRQHEVFE 1227

  Fly  1228 RDLAALRDKIRQLDETANRLMQSHPDTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRF 1292
            ||:..|.:|:..|.|||.||.:||||..|....::.|:||.||.:...::.|||.|.:::....|
  Rat  1228 RDIIPLGEKVTTLGETAERLCESHPDATEDLQKQRTELNEAWDTLQGLTSDRKESLNEAHKFFLF 1292

  Fly  1293 LSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAASTSSIAS 1357
            ||...||..||.::..:::|.|||.|:||.|.|:||||                           
  Rat  1293 LSKASDLENWIKAIGGVISSPELAEDLTGTEILLERHQ--------------------------- 1330

  Fly  1358 PSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLE 1422
                 ||..:|.....||.|.|.||.||:...|..|.||:..::|:...|:||||.|..|:..|:
  Rat  1331 -----EHYDDIKREDPTFQALEDFGRELIDRGHRNSHEIETTLQDIKLKRDDLEKNWENRKKMLD 1390

  Fly  1423 QNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQTV 1487
            |.|:|||:...||..||||.|||..|.:||..:. .:::||:||.:|.||||...|.|||.|:..
  Rat  1391 QCLELQLFRGKCEQVESWMVARENSLRSDDRDHL-NSLQALMKKRDDLDKAIAAQEGKIADLENH 1454

  Fly  1488 ADQLIAQNHYASNLVDEKRKQVLERWRHLKEGLIEKRSRLGDEQTLQQFSRDADEIENWIAEKLQ 1552
            |.:|:..:|||...:..:.::||:||:.||..|:.:..:|||...|:||.||.:::|.||:|.|.
  Rat  1455 ATRLMDNDHYAKEEIAARLQRVLDRWKDLKTQLLAELGKLGDYADLKQFYRDLEDLEEWISEMLP 1519

  Fly  1553 LATEESYKDPANIQSKHQKHQAFEAELAANADRIQSVLAMGGNLIDKKQCSGSEDAVQKRLTQIA 1617
            :|.:||||||.|||.|:.||||||.|:...|::::.|:.:|.:||:::.|.|.|:.:|::|.::.
  Rat  1520 VACDESYKDPTNIQRKYLKHQAFENEVNGRAEQVEGVINLGKSLIERRVCDGDEENMQEQLDKLK 1584

  Fly  1618 DQWEYLTHKTTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKKHQL 1682
            :.|:||..:||:|..||.||::|:.:..:::|.:|||.|.|.||..:|..:||.|..||:|||||
  Rat  1585 ENWDYLLERTTDKGQKLNEASRQQRFNTSIRDFEFWLSEAEGLLAMKDQARDLTSAGNLLKKHQL 1649

  Fly  1683 VEADIVAHEDRIKDMNNQADSLVESGQFDTAGIQEKRQSINERYERICNLAAHRQARLNEALTLH 1747
            :||:::|.||.:||:|..|..|:.||.|:...|:||...:|||::.:.:|||....:|.|...|.
  Rat  1650 LEAEMLAREDPLKDLNGLAKELISSGTFNIEQIEEKMNGVNERFKNVQSLAAAHHEKLKETYALF 1714

  Fly  1748 QFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGSHEPAIQAVQEAGEKLMD 1812
            |||:|:.|||:||:||.|.|.|.|.||||..||||.|||:|||.||.:||||:|.|.:..|.|.|
  Rat  1715 QFFQDLDDEEAWIEEKLLRVSSQDCGRDLQSVQNLLKKHRRLEGELVAHEPAVQNVLDTAESLKD 1779

  Fly  1813 VSNLGVPEIEQRLKALNQAWAELKNLAATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLLSVED 1877
            .:.:|..||::||....|.|.:||.||.|||..|:|||.|.||:...||||||:.||..|:|..|
  Rat  1780 KAAVGKEEIQERLAQFVQHWEKLKELAKTRGVNLEESLQYLQFMENAEEEEAWLGEKDALVSRGD 1844

  Fly  1878 YGDSMAAVQGLLKKHDAFETDFTAHKDRCSLICDQGSELV-EAKNHHGESIAQRCQQLRLKLDNL 1941
            .||::||.|.|||||:|.|.||..||:|...:|.||.::: :.:..:.:.|:.:.:.|..|..:|
  Rat  1845 SGDTLAATQSLLKKHEALENDFAVHKNRVQDVCAQGEDILSKEETQNKDKISTKIEVLNEKTASL 1909

  Fly  1942 SALAARRKGALLDNSAYLQFMWKADVVESWIDDKENYVRSDEFGRDLSTVQTLLTKQETFDAGLN 2006
            :...|..|..|.:..|:.||.||||||||||.:||..:::...|.||:...|||.||:|.||.|.
  Rat  1910 TKALAAWKSQLDEVHAFQQFNWKADVVESWIGEKEASLKTKSNGADLTAFLTLLAKQDTLDASLQ 1974

  Fly  2007 AFEQEGIHNITALKDQLINASHAQSPAILKRHGDVIARWQKLRDASNTRKDRLLAMQEQFRQIEE 2071
            :|:||.:..||.|||:|:.|.|:||.||.:||..::.||::|.:|....:.:||..|...::.||
  Rat  1975 SFQQERLSEITDLKDELLAAEHSQSKAIEERHAALLRRWEQLLEACRVHRQKLLEKQLPLQKAEE 2039

  Fly  2072 LYLTFAKKASAFNSWFENAEEDLTDPVRCNSIEEIRALRDAHAQFQASLSSAEADFKALAALDQK 2136
            |::.||.||||||:|.|||||||::||.|.|:.|||.|:..|..|.||:..|:.||..|.||||:
  Rat  2040 LFMEFAHKASAFNNWCENAEEDLSEPVHCVSLNEIRQLQKEHEAFLASMVGAQEDFNYLLALDQQ 2104

  Fly  2137 IKSFNVGPNPYTWFTMEALEETWRNLQKIIEERDGELAKEAKRQEENDKLRKEFAKHANLFHQWL 2201
            ||:.||..:||||.|::.|...|::|.:||:||:.||.||..||.:|.::.:||.::|:.|.||:
  Rat  2105 IKALNVSSSPYTWLTVDVLGRIWKHLPEIIKEREQELQKEEARQIKNFEMCQEFEQNASAFLQWI 2169

  Fly  2202 TETRYYMLGYNRQGTSMMEGSGSLEQQLEALRVKATEVRARRVDLKKIEELGALLEEHLILDNRY 2266
            .|||.|.|     ..|:::.:|:||.||||.:.|..|::|.:..|.|||:||..:||.||||.:|
  Rat  2170 QETRAYFL-----DGSLLKETGTLESQLEANKRKQKEIQAMKRHLTKIEDLGDSMEEALILDIKY 2229

  Fly  2267 TEHSTVGLAQQWDQLDQLSMRMQHNLEQQIQARNHSGVSEDSLKEFSMMFKHFDKDKSGKLNHQE 2331
               ||:|||||||||.||.|||||||||||||::..||||::|||||..:||||::.:|:|.|:|
  Rat  2230 ---STIGLAQQWDQLHQLGMRMQHNLEQQIQAKDTIGVSEETLKEFSTTYKHFDENLTGRLTHKE 2291

  Fly  2332 FKSCLRALGYDLPMVEEGQPDPEFEAILDVVDPNRDGYVSLQEYIAFMISKETENVQSYEEIENA 2396
            |:||||.|.|.|||||||:|:|:||..|:.|||.|.|||||::|.:|:|.||:||:::.::||:.
  Rat  2292 FRSCLRGLNYYLPMVEEGEPEPKFEKFLNAVDPGRKGYVSLEDYTSFLIDKESENIKTSDDIESG 2356

  Fly  2397 FRAITAADRPYVTKEELYCNLTKDMADYCVQRMKPFSEPRS-GQPIKDALDYIDFTRTLFQN 2457
            |:|: |..:.|:|||::...||.:...:|...|:.:.:||. .||.  ..||:.||.:.|.|
  Rat  2357 FQAL-AEGKAYITKEDMKQALTPEQVSFCTIHMQQYMDPRGRSQPA--GYDYVGFTNSFFGN 2415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 36/52 (69%)
SPEC 1074..1287 CDD:238103 87/214 (41%)
SPEC 1182..1425 CDD:238103 92/242 (38%)
SPEC 1426..1638 CDD:238103 91/211 (43%)
SPEC 1533..1744 CDD:238103 92/210 (44%)
SPEC 1646..1850 CDD:238103 100/203 (49%)
SPEC 1852..2062 CDD:238103 91/210 (43%)
SPEC 1958..2176 CDD:238103 107/217 (49%)
SPEC 2072..2296 CDD:238103 117/223 (52%)
EFh 2311..2379 CDD:238008 40/67 (60%)
EFhand_Ca_insen 2386..2456 CDD:400872 22/70 (31%)
SPEC 48..258 CDD:238103 86/209 (41%)
SPEC 154..364 CDD:238103 81/209 (39%)
SPEC 261..470 CDD:238103 88/208 (42%)
SPEC 471..680 CDD:238103 106/208 (51%)
SPEC 682..893 CDD:238103 90/210 (43%)
Spectrin 893..>961 CDD:395348 38/67 (57%)
Spta1NP_001011908.3 SPEC 53..261 CDD:238103 86/208 (41%)
SPEC 263..474 CDD:238103 88/210 (42%)
SPEC 475..685 CDD:238103 107/209 (51%)
SPEC 686..893 CDD:238103 88/206 (43%)
SPEC 900..>956 CDD:197544 32/55 (58%)
SH3 980..1031 CDD:418401 36/50 (72%)
Spectrin 1080..1177 CDD:395348 36/105 (34%)
SPEC 1184..1393 CDD:238103 91/240 (38%)
SPEC 1394..1604 CDD:238103 90/210 (43%)
SPEC 1606..1817 CDD:238103 101/210 (48%)
SPEC 1713..1924 CDD:238103 100/210 (48%)
SPEC 1926..2144 CDD:238103 107/217 (49%)
SPEC 2040..2256 CDD:238103 117/223 (52%)
FRQ1 2265..>2379 CDD:227455 61/114 (54%)
EFhand_Ca_insen 2346..2414 CDD:400872 22/70 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I10942
eggNOG 1 0.900 - - E1_KOG0040
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51850
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 1 1.000 - - FOG0004911
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 1 1.100 - - O PTHR11915
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.830

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