DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Spec and Sptbn2

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_067262.1 Gene:Sptbn2 / 20743 MGIID:1313261 Length:2388 Species:Mus musculus


Alignment Length:1765 Identity:473/1765 - (26%)
Similarity:806/1765 - (45%) Gaps:272/1765 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 RREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQ-AASEESYRDPTNLQAK 84
            |..::.:::...:....::.::|..:.....|:.||:::|:|:.:.|: .:|.|...|..:.||.
Mouse   721 RAAELQAQWERLEALAEERAQQLAQAASLYQFQADANDMEAWLVDALRLVSSPEVGHDEFSTQAL 785

  Fly    85 IQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFA-------SESIQVRLDELHKLWELLLSRLA 142
            .::|:|.|.|:.||...:        :.:.:|..|       :..:|.|:..|.:.:|.|.:|..
Mouse   786 ARQHRALEEEIRAHRPTL--------DALREQAAALPPALSHTPEVQGRVPTLEQHYEELQARAG 842

  Fly   143 EKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQKDMASQEYR 207
            |:...|:.||.....|.:......|:::||.::......:.||.:||:|::|:..:.:|.:...|
Mouse   843 ERARALEAALAFYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNALAAR 907

  Fly   208 VTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNRDADETVA 272
            ||.||.:|::|::...|.:|.|...:|:||:.||:.:.||..::..|..|..||.::.:..||.|
Mouse   908 VTAVNDIAEQLLKASPPGKDRIIGTQEQLNQRWQQFRSLADGKKAALTSALSIQNYHLECTETQA 972

  Fly   273 WIAEK-DVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLCSIHADHSDQIR 336
            |:.|| .|:.|:...|.|||.|.|||||..|.||||.|:..:|..|..||..|.:.|...:..|.
Mouse   973 WMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAISARVGELTQEANALAAGHPAQAPAIN 1037

  Fly   337 DKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELAKDVAGAEA 401
            .:..|:...|:.|....|.|::.|.|:..|..||....|..:|:...:..::::|....:..|||
Mouse  1038 TRLGEVQAGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEA 1102

  Fly   402 LLERHQEHKGEID-AREDSFKLTTESGQKLLEREHYAAAEIQEKLAALENDKSSLLSLWEDRRIL 465
            ||.:|...:||:: |:.:..:|.|...:...::.......::::|.||......|..:||.|:..
Mouse  1103 LLAQHAALRGEVERAQSEYSRLRTLGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGR 1167

  Fly   466 YEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEKIKALD 530
            ..|....|.|.||..||:..::.||..|::.::..:|.:.:|.|||.|||..::.|..|:|:.|.
Mouse  1168 LAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIRGLL 1232

  Fly   531 IFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFERDCDETKGWISEK 595
            ....:|:...:..|:.:.::...:..|....||...:....|.|:...|.|.:||.|.:.||.||
Mouse  1233 EAGRQLVSKGNIHAEKIQEKADSIEKRHRKNQEAVQQLLGRLRDNREQQHFLQDCQELRLWIDEK 1297

  Fly   596 LKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAADQINTRMQEIV 660
            :..|.|.||.:..||:.|.||||.|..||.|||..::.:...|.||..::......::.:::::.
Mouse  1298 MLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKVVVSEKLEDLH 1362

  Fly   661 VLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQKKHAL 725
            ..|:.|...:..|...|.:|.:.:.|.::...:|.||..::.||.|:|:|||||||..|.||..:
Mouse  1363 RRWDELETTTQAKARSLFDANRAELFAQSCSALESWLESLQAQLHSDDYGKDLTSVNILLKKQQM 1427

  Fly   726 LEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAPMGERKQHLLDSLQVQ 790
            ||.::...:..:|:|:..|....:... .|..:......:..::.||..||.||.:.|..|.:..
Mouse  1428 LEREMAVREKEVEAIQAQAQALAQEDQ-SAGEVERTSRAVEEKFRALCQPMKERCRRLHASREQH 1491

  Fly   791 QLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLNVISSGENMLK 855
            |..||:|||..|:.|:.|:|:|...|:||..||.|:||:|.:..||..||.|:.:        ||
Mouse  1492 QFHRDVEDEILWVTERLPMASSLEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIAD--------LK 1548

  Fly   856 DQPFASDDIRQR----------LEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEAESWMR 910
            :        |||          |..|||.|..|..:...|.:.|:::|:|.|::.||.|||:||.
Mouse  1549 E--------RQRTLGTAAAGPELAELQEMWKRLSHELELRGKRLEEALRAQQFYRDAAEAEAWMG 1605

  Fly   911 EKEPIATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETPVVDITGKECV 975
            |:|....|.:..|||.|::|.:|||:.|.          |||.:.|:..:|              
Mouse  1606 EQELHMMGQEKAKDELSAQAEVKKHQVLE----------QALADYAQTIKQ-------------- 1646

  Fly   976 VALYDYTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLSASQQNLVD 1040
                                                                   |:||.|:::|
Mouse  1647 -------------------------------------------------------LAASSQDMID 1656

  Fly  1041 NH-----SIAKRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQIAD 1100
            :.     .:..||.|::..|.:|..||.||:.:|.|.::...|.||..||.|||:::|..| .:.
Mouse  1657 HEHPESTRLTIRQAQVDKLYASLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVA-ASH 1720

  Fly  1101 VVGEDLEEVEVLQKKFDDFNDDLKA-NEVRLANMNEIAVQLTSLGQTEAALKIQTQMQD-LNEKW 1163
            .:|:|.|.|.:|:.||.:|:.|... .:.|:.:.|.:|..|.:.|  .||.....:.:| |||.|
Mouse  1721 ELGQDYEHVTMLRDKFREFSKDTSTIGQERVDSANALANGLIAGG--HAARATVAEWKDSLNEAW 1783

  Fly  1164 NNLQTLTAEKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVER 1228
            .:|..|...:...|.:|:|:|||.....:....:..|...| .|..|:||.:.:.|||:|...|.
Mouse  1784 ADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQL-PDGTGRDLNAAEALQRRHCAYEH 1847

  Fly  1229 DLAALRDKIRQLDETANRLMQSHP-DTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRF 1292
            |:.||..:::|:.:...||.:::. |.||:.....:.:.|.|.|:...|.||::.|||:.|..||
Mouse  1848 DIQALSTQVQQVQDDGQRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRF 1912

  Fly  1293 LSDYRDLLAWINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAASTSSIAS 1357
            ....|:|:.|::.:...:.:.|...||:.|:.:|:..|..:|                       
Mouse  1913 FKAVRELMLWMDGINLQMDAQERPRDVSSADLVIKNQQGIKA----------------------- 1954

  Fly  1358 PSGDEEHRTEIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLE 1422
                     ||:|||..|.:....|.|||..:|||:.||.||:..|...|::....|.|:...|:
Mouse  1955 ---------EIEARADRFSSCIDMGQELLARSHYAAEEISEKLSQLQSRRQETADKWQEKMDWLQ 2010

  Fly  1423 QNLDLQLYMRDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQTV 1487
            ..|::.::.||..:||:|:.::|..:.:.:.......||:|||:||.|.|:....|::.:||:.:
Mouse  2011 LVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFSALEKL 2075

  Fly  1488 -------------------------ADQLIAQNHYASNLVDEKR--------------------- 1506
                                     ::.:.:|..  .:|||.:|                     
Mouse  2076 TALEERENERKRKREEEERRKQPPTSEPMASQPE--GSLVDGQRVPDTAWDGTQSKLPPSTQAPS 2138

  Fly  1507 -----------KQVLERWR----HLKEGLIEKRSRLGDE--------QTL----------QQFSR 1538
                       :.:||:.|    ::.||   ..|..|||        |||          |..|.
Mouse  2139 VNGVCTDTDSSQPLLEQQRLEQSNVPEG---PGSGTGDESSGPRGERQTLPRGPAPSPMPQSRSS 2200

  Fly  1539 DADEIENWIAEKLQLATEESYKDPANIQSKHQKHQAFEAELAANA--DRIQSVLAMG--GNLIDK 1599
            :|...........:|:.:|..:   .:..:.|:.:||..: |||.  ..:..||..|  |...|.
Mouse  2201 EAAHGATLPTRGPELSAQEQME---GMLCRKQEMEAFNKK-AANRSWQNVYCVLRRGSLGFYKDA 2261

  Fly  1600 KQCSG-----SEDAVQKRLTQIADQWEYLTHKTTEKSLKLKEANKQRTYIAAVKD---LDFWLGE 1656
            :..|.     .|..|.....|.:..::|...|...| |.|::.   :.|:...||   :..||..
Mouse  2262 RAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFK-LGLQDG---KEYLFQAKDEAEMSSWLRV 2322

  Fly  1657 VESLLTTEDS 1666
            |.:.:.|..|
Mouse  2323 VNAAIATASS 2332

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 0/51 (0%)
SPEC 1074..1287 CDD:238103 68/215 (32%)
SPEC 1182..1425 CDD:238103 68/243 (28%)
SPEC 1426..1638 CDD:238103 60/299 (20%)
SPEC 1533..1744 CDD:238103 34/156 (22%)
SPEC 1646..1850 CDD:238103 7/24 (29%)
SPEC 1852..2062 CDD:238103
SPEC 1958..2176 CDD:238103
SPEC 2072..2296 CDD:238103
EFh 2311..2379 CDD:238008
EFhand_Ca_insen 2386..2456 CDD:400872
SPEC 48..258 CDD:238103 58/217 (27%)
SPEC 154..364 CDD:238103 70/210 (33%)
SPEC 261..470 CDD:238103 64/210 (30%)
SPEC 471..680 CDD:238103 61/208 (29%)
SPEC 682..893 CDD:238103 70/220 (32%)
Spectrin 893..>961 CDD:395348 26/67 (39%)
Sptbn2NP_067262.1 SAC6 51..>441 CDD:227401
Spectrin 429..522 CDD:334073
SPEC 534..746 CDD:238103 2/24 (8%)
SPEC 749..958 CDD:238103 58/216 (27%)
SPEC 961..1172 CDD:238103 64/210 (30%)
SPEC 1174..1383 CDD:238103 61/208 (29%)
SPEC 1384..1588 CDD:238103 70/220 (32%)
SPEC 1589..1801 CDD:238103 76/293 (26%)
SPEC 1802..2010 CDD:238103 67/240 (28%)
SPEC 2018..>2075 CDD:197544 18/56 (32%)
PH_beta_spectrin 2221..2326 CDD:269975 26/112 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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