DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment alpha-Spec and spc-1

DIOPT Version :9

Sequence 1:NP_001261286.1 Gene:alpha-Spec / 38231 FlyBaseID:FBgn0250789 Length:2457 Species:Drosophila melanogaster
Sequence 2:NP_001257000.1 Gene:spc-1 / 180603 WormBaseID:WBGene00004951 Length:2432 Species:Caenorhabditis elegans


Alignment Length:2459 Identity:1519/2459 - (61%)
Similarity:1902/2459 - (77%) Gaps:53/2459 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 PKEVKILETVEDIQERREQVLSRYNDFKIETRQKREKLEDSRRFQYFKRDADELESWIHEKLQAA 70
            |:|::||||.:||.:||::||..|:.||..::.||::||::|:|||||||||||..||.||||.|
 Worm    20 PQEIRILETADDIHQRRQEVLGHYSIFKDHSQTKRDRLEEARQFQYFKRDADELNVWILEKLQTA 84

  Fly    71 SEESYRDPTNLQAKIQKHQAFEAEVSAHSNAIVSLDNTGQEMINQQHFASESIQVRLDELHKLWE 135
            .||::|||:|||||||||:||||||.||:..|.:||.||..||...|||||.|:.||:|||.||:
 Worm    85 QEENFRDPSNLQAKIQKHEAFEAEVQAHAKTIANLDKTGNAMIQHNHFASEHIKKRLEELHALWD 149

  Fly   136 LLLSRLAEKGLKLQQALVLVQFLRQCEEVMFWIKDKETFVTADEFGQDLEHVEVLQRKFDEFQKD 200
            .|..:|.:||:||||||.|:.|:|||:|:::||::|||:|||::.|.||||||:||||||:|.|:
 Worm   150 KLFFKLKDKGIKLQQALKLLHFIRQCDEILYWIREKETYVTAEDMGMDLEHVEILQRKFDDFLKE 214

  Fly   201 MASQEYRVTEVNQLADKLVQDGHPERDTITKRKEELNEAWQRLKQLAIVRQEKLFGAHEIQRFNR 265
            :.:.:||:.|:||.|||||::||.|.|.|.|:::::|:||.||..||..|:|.|||||::|||||
 Worm   215 LGNHQYRINEINQAADKLVEEGHSEHDQIYKKRDDVNDAWHRLNTLAATRKEGLFGAHQVQRFNR 279

  Fly   266 DADETVAWIAEKDVVLSSDDYGRDLASVQALQRKHEGVERDLAALEDKVSTLGAEAQRLCSIHAD 330
            |||||:|||.|||:.||||||||||.:||||||||||.||||||||.|:..|..||.:|...|.|
 Worm   280 DADETLAWIGEKDLALSSDDYGRDLNNVQALQRKHEGTERDLAALEGKMLQLEKEAHKLAETHPD 344

  Fly   331 HSDQIRDKQAEIANYWQSLTTKARERKQKLDESYYLHRFLADFRDLVSWINGMKAIISADELAKD 395
            .::.|..|..:....|.:|..||:.||..|:.|:.|||||||:|||:|||..|||:|.|||||||
 Worm   345 RAEAIHQKNDDTKAAWNALKEKAQHRKDGLERSFQLHRFLADYRDLISWIGDMKAVIGADELAKD 409

  Fly   396 VAGAEALLERHQEHKGEIDAREDSFKLTTESGQKLLEREHYAAAEIQEKLAALENDKSSLLSLWE 460
            |||||||||.|||||||||||.|||..|..:||||:|.....:.|:||||..|:::|||||.|||
 Worm   410 VAGAEALLESHQEHKGEIDARADSFNQTASAGQKLVEMGIPESPEVQEKLEKLDHEKSSLLGLWE 474

  Fly   461 DRRILYEQCMDLQLFYRDTEQADTWMAKQEAFLANEDLGDSLDSVEALIKKHEDFEKSLAAQEEK 525
            :|||||||||||||||||||||:|||.||||||||.||||||||||.||||||||||||||||||
 Worm   475 ERRILYEQCMDLQLFYRDTEQAETWMNKQEAFLANTDLGDSLDSVEHLIKKHEDFEKSLAAQEEK 539

  Fly   526 IKALDIFATKLIDGQHYAADDVAQRRQMLLARRAALQEKSSKRRQLLEDSNRYQQFERDCDETKG 590
            |.|||.||||||.||||||||||:|||.||.||..|.:::.:|...|::|.:.|.|:|||||...
 Worm   540 INALDEFATKLIQGQHYAADDVAERRQALLDRRRRLLDRARQRGNALKESYKRQTFDRDCDEMVS 604

  Fly   591 WISEKLKFATDDSYLDPTNLNGKMQKHQNFEHELNANKSRIEDITNVGTELIEKQHYAADQINTR 655
            ||:|||..|.|||||||||:.||:|||.|||.||.||::|::||.:.|.::|:..|:|||.|..|
 Worm   605 WITEKLSTARDDSYLDPTNIRGKLQKHINFEQELKANENRLDDIRSTGEQIIDSGHFAADHIGDR 669

  Fly   656 MQEIVVLWETLVQASDKKGTKLNEACQQQQFNRTIEDIELWLSEIEGQLLSEDHGKDLTSVQNLQ 720
            ::::..||..||.|::|||.||.||..:|||||.|||:|.||||:|||:.|||:||||.||||||
 Worm   670 LRQVNNLWNELVDATNKKGAKLREAGNEQQFNRNIEDVEAWLSELEGQVASEDYGKDLVSVQNLQ 734

  Fly   721 KKHALLEADVMAHQDRIESIKVAANKFIESGHFDADNIRNKEGNLSARYAALAAPMGERKQHLLD 785
            ||..|:|:|..||.||::.||..|.:|.|..||:|..|..|:.||..||.||..|:.:||:.|.:
 Worm   735 KKIGLIESDFNAHNDRVDGIKQLAQQFQEEEHFNAPVIVRKQENLQQRYNALRDPLEKRKRKLGE 799

  Fly   786 SLQVQQLFRDLEDEAAWIREKEPIAASTNRGRDLIGVQNLIKKHQAVLAEINNHEARLLNVISSG 850
            |.|..|||||:|||.|||||||.:|.|||||||||||||||||.||::|||.||::::.:|.|:.
 Worm   800 SHQGNQLFRDIEDELAWIREKEQVAGSTNRGRDLIGVQNLIKKQQALIAEIANHDSQIESVSSAA 864

  Fly   851 ENMLKDQPFASDDIRQRLEALQEQWNTLKEKSSQRKQDLDDSLQAHQYFADANEAESWMREKEPI 915
            .:|::...|.:.:||.:|..|::.|..||.|:.:|:.|||||||||||.:|||||::||.|||||
 Worm   865 NDMIQQGHFLAPEIRDKLAQLRDNWRILKSKAEKRRTDLDDSLQAHQYLSDANEADAWMSEKEPI 929

  Fly   916 ATGSDYGKDEDSSEALLKKHEALVSDLEAFGNTIQALQEQAKNCRQQETPVVDITGKECVVALYD 980
            ...:||||||||:|||||||.||:||||||..||:.|::||..|:.||.|:..: |::||:||||
 Worm   930 VGSTDYGKDEDSAEALLKKHRALLSDLEAFKGTIEDLRKQASQCKYQEQPMGQL-GRDCVLALYD 993

  Fly   981 YTEKSPREVSMKKGDVLTLLNSNNKDWWKVEVNDRQGFVPAAYIKKIDAGLSASQQNLVDNHSIA 1045
            |.|||||||||||||||||||::|:||||||||||||||||||:|:|:.| :|.|......:||.
 Worm   994 YQEKSPREVSMKKGDVLTLLNASNRDWWKVEVNDRQGFVPAAYVKRIEPG-TAQQHAQQQVNSIG 1057

  Fly  1046 KRQNQINSQYDNLLALARERQNKLNETVKAYVLVREAADLAQWIRDKENHAQIA----DVVGEDL 1106
            .:|::|..:|..|:.|...|:.||.|..|.|.|:|||.|||:||:.:.|.|:.|    ..:|.||
 Worm  1058 GKQSEIEDKYQRLMMLGETRKRKLEEACKGYQLLREANDLAEWIKSRTNMAEEAVAAQQEIGTDL 1122

  Fly  1107 EEVEVLQKKFDDFNDDLKANEVRLANMNEIAVQLTSLGQTEAALKIQTQMQDLNEKWNNLQTLTA 1171
            |:|||||||||||..|||||||||..||:||..|||:||||.|::|:.|::|||.:|..|:..|.
 Worm  1123 EQVEVLQKKFDDFKGDLKANEVRLQEMNQIATALTSVGQTETAVRIRQQIEDLNARWRALEEQTE 1187

  Fly  1172 EKASQLGSAHEVQRFHRDIDETKDWIAEKANALNNDDLGKDLRSVQTLQRKHEGVERDLAALRDK 1236
            ::..||||||||||||||:|||:|||.||.:||:::|.|:||||||.|||||||||||||||.||
 Worm  1188 QREQQLGSAHEVQRFHRDVDETRDWIQEKDDALDSEDFGRDLRSVQALQRKHEGVERDLAALGDK 1252

  Fly  1237 IRQLDETANRLMQSHPDTAEQTYAKQKEINEMWDQIITKSTARKEKLLDSYDLQRFLSDYRDLLA 1301
            |:.|||.||||.||||:.|||.|..|:|:||.|:::.:|:..||||||||||.||||||||||:.
 Worm  1253 IKSLDEKANRLRQSHPEAAEQIYDLQRELNEQWNRLTSKANNRKEKLLDSYDYQRFLSDYRDLMQ 1317

  Fly  1302 WINSMMSLVTSDELANDVTGAEALIERHQARRAEIGFTLGISSAPGAAASTSSIASPSGDEEHRT 1366
            ||.||..||:|.||||||||||||:||||                                |:||
 Worm  1318 WIASMNQLVSSQELANDVTGAEALLERHQ--------------------------------EYRT 1350

  Fly  1367 EIDARAGTFGAFEQFGNELLQANHYASPEIKEKIEDLAKAREDLEKAWTERRLQLEQNLDLQLYM 1431
            |||:||.||.||:||||:||.::|||:.:|:.:::.:.:||:.||.||..||..|:|.|:|||:.
 Worm  1351 EIDSRAATFQAFDQFGNQLLNSHHYAAGDIENRLQGVNEARKGLEDAWVARRNILDQCLELQLFY 1415

  Fly  1432 RDCELAESWMSAREAFLNADDDANAGGNVEALIKKHEDFDKAINGHEQKIAALQTVADQLIAQNH 1496
            ||||.|::|||||||||..:|.  :|.|||:|||||||||||||..|:||..|:..|:.||..||
 Worm  1416 RDCEQADTWMSAREAFLAQEDP--SGDNVESLIKKHEDFDKAINTQEEKIKGLKLFAESLIKNNH 1478

  Fly  1497 YASNLVDEKRKQVLERWRHLKEGLIEKRSRLGDEQTLQQFSRDADEIENWIAEKLQLATEESYKD 1561
            |.|..|..||.|:|:||..|||.||:||.:||:.||||||||||||||||:.||.|:|.||:|:|
 Worm  1479 YDSPAVTRKRDQILDRWNGLKEALIQKRFKLGESQTLQQFSRDADEIENWMTEKFQIAQEENYRD 1543

  Fly  1562 PANIQSKHQKHQAFEAELAANADRIQSVLAMGGNLIDKKQCSGSEDAVQKRLTQIADQWEYLTHK 1626
            |.|||.||||.|||||||.||:|||.:::..|.|||:..:|.|.|.||..||..:.|||:.|...
 Worm  1544 PTNIQQKHQKQQAFEAELHANSDRIAAIIQAGNNLIENAKCGGGEAAVSARLKALNDQWDLLVKT 1608

  Fly  1627 TTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTTEDSGKDLASVQNLMKKHQLVEADIVAHE 1691
            |||||.:|||||||::::||||||:|||||||.||.:||.|||||||:||:|||.|:|||||||:
 Worm  1609 TTEKSYRLKEANKQKSFMAAVKDLEFWLGEVEILLQSEDYGKDLASVENLLKKHSLLEADIVAHQ 1673

  Fly  1692 DRIKDMNNQADSLVESGQFDTAGIQEKRQSINERYERICNLAAHRQARLNEALTLHQFFRDIADE 1756
            ||:.:||.|||||:|:.||....|.|:|:.|.:||:.:..:|..|:.:|::||.:|||||||.||
 Worm  1674 DRVGEMNEQADSLLENDQFQGQQIAERRKLIADRYDGVKKMATDRRDKLSKALNVHQFFRDIDDE 1738

  Fly  1757 ESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELGSHEPAIQAVQEAGEKLM-DVSNLGVPE 1820
            |||||||||||.||||||||.|||||::||:|::.||.||||.:..|:..||:|: ..:..||.|
 Worm  1739 ESWIKEKKLLVSSDDYGRDLPGVQNLRRKHRRIDTELASHEPQVSLVKLKGEELLRSAAEAGVGE 1803

  Fly  1821 --IEQRLKALNQAWAELKNLAATRGQKLDESLTYQQFLAQVEEEEAWITEKQQLLSVEDYGDSMA 1883
              |::|::.|.|:|.::::|...|.|:||||..:|.||..|||||||:.||||:|..:::|::||
 Worm  1804 DQIKKRMEDLEQSWGQIRDLTGNRHQRLDESEAFQAFLGDVEEEEAWMNEKQQILGSDNFGENMA 1868

  Fly  1884 AVQGLLKKHDAFETDFTAHKDRCSLICDQGSELVEAKNHHGESIAQRCQQLRLKLDNLSALAARR 1948
            .|||||||||.|:.|...||.|.:.:.::|..|:...|||...|.|||.|||.:|..:.::|..|
 Worm  1869 GVQGLLKKHDTFQVDLELHKQRVADLINKGDTLIHNGNHHAPHIKQRCDQLRARLIEIESMAEGR 1933

  Fly  1949 KGALLDNSAYLQFMWKADVVESWIDDKENYVRSDEFGRDLSTVQTLLTKQETFDAGLNAFEQEGI 2013
            ...|.|||||||||||.|||||||.:||..|||::||||||:||.||||||.|||||||||.|||
 Worm  1934 LAKLRDNSAYLQFMWKCDVVESWIAEKEQQVRSEDFGRDLSSVQILLTKQEAFDAGLNAFEHEGI 1998

  Fly  2014 HNITALKDQLINASHAQSPAILKRHGDVIARWQKLRDASNTRKDRLLAMQEQFRQIEELYLTFAK 2078
            ..||.|||||:::.|.|||||.|||.:||.|||.|...|..|:.:||.||:||:|||||||.|||
 Worm  1999 QRITELKDQLVSSEHQQSPAIEKRHTNVIQRWQNLLAHSEARRQKLLKMQQQFKQIEELYLAFAK 2063

  Fly  2079 KASAFNSWFENAEEDLTDPVRCNSIEEIRALRDAHAQFQASLSSAEADFKALAALDQKIKSFNVG 2143
            |||.||||||||||||||||||||:||||||||||.:||.||||||.||:.|..||::|||||||
 Worm  2064 KASTFNSWFENAEEDLTDPVRCNSLEEIRALRDAHGEFQRSLSSAEEDFRQLQDLDRRIKSFNVG 2128

  Fly  2144 PNPYTWFTMEALEETWRNLQKIIEERDGELAKEAKRQEENDKLRKEFAKHANLFHQWLTETRYYM 2208
            |||||||||:|||:||||||:||:||:.|||:|.:|||||||||:||||.||.||.|||.||   
 Worm  2129 PNPYTWFTMDALEDTWRNLQRIIKEREQELAREHQRQEENDKLRREFAKLANAFHAWLTNTR--- 2190

  Fly  2209 LGYNRQGTSMMEGSGSLEQQLEALRVKATEVRARRVDLKKIEELGALLEEHLILDNRYTEHSTVG 2273
                   ..|||..|:||:||:|:..||.|::|.:..|::|||.||:||.:||||||||||||||
 Worm  2191 -------QEMMEAGGTLEEQLDAVERKAKEIKANKGQLRQIEEKGAMLERNLILDNRYTEHSTVG 2248

  Fly  2274 LAQQWDQLDQLSMRMQHNLEQQIQARNHSGVSEDSLKEFSMMFKHFDKDKSGKLNHQEFKSCLRA 2338
            :||.|||||||:|||||||||||||||.|||||::|:|||||||||||:|:|:|:||:|||||||
 Worm  2249 IAQAWDQLDQLAMRMQHNLEQQIQARNQSGVSEEALREFSMMFKHFDKEKTGRLDHQQFKSCLRA 2313

  Fly  2339 LGYDLPMVEEGQPDPEFEAILDVVDPNRDGYVSLQEYIAFMISKETENVQSYEEIENAFRAITAA 2403
            ||||||||:||||:|||:.|||:|||||||||:||||:||||||||||:||.||||.||||::..
 Worm  2314 LGYDLPMVDEGQPEPEFQRILDIVDPNRDGYVTLQEYMAFMISKETENIQSSEEIEMAFRALSKE 2378

  Fly  2404 DRPYVTKEELYCNLTKDMADYCVQRMKPFSEPRSGQPIKDALDYIDFTRTLFQN 2457
            .|||||.||||.|||.:.|::|::||||:.:..||:.|:..|||..|...|||:
 Worm  2379 FRPYVTAEELYANLTPEQAEFCIRRMKPYMDAISGRSIQGGLDYEQFVHALFQS 2432

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-SpecNP_001261286.1 SH3_Alpha_Spectrin 974..1026 CDD:212742 45/51 (88%)
SPEC 1074..1287 CDD:238103 136/216 (63%)
SPEC 1182..1425 CDD:238103 140/242 (58%)
SPEC 1426..1638 CDD:238103 129/211 (61%)
SPEC 1533..1744 CDD:238103 127/210 (60%)
SPEC 1646..1850 CDD:238103 119/206 (58%)
SPEC 1852..2062 CDD:238103 123/209 (59%)
SPEC 1958..2176 CDD:238103 163/217 (75%)
SPEC 2072..2296 CDD:238103 160/223 (72%)
EFh 2311..2379 CDD:238008 55/67 (82%)
EFhand_Ca_insen 2386..2456 CDD:400872 37/69 (54%)
SPEC 48..258 CDD:238103 127/209 (61%)
SPEC 154..364 CDD:238103 119/209 (57%)
SPEC 261..470 CDD:238103 135/208 (65%)
SPEC 471..680 CDD:238103 137/208 (66%)
SPEC 682..893 CDD:238103 117/210 (56%)
Spectrin 893..>961 CDD:395348 47/67 (70%)
spc-1NP_001257000.1 SPEC 62..272 CDD:238103 127/209 (61%)
SPEC 273..484 CDD:238103 135/210 (64%)
SPEC 485..694 CDD:238103 137/208 (66%)
SPEC 593..801 CDD:238103 115/207 (56%)
SPEC 698..907 CDD:238103 117/208 (56%)
Spectrin 907..>973 CDD:278843 46/65 (71%)
SH3_Alpha_Spectrin 987..1039 CDD:212742 45/51 (88%)
SPEC 1088..1303 CDD:238103 135/214 (63%)
SPEC 1198..1409 CDD:238103 140/242 (58%)
SPEC 1412..1509 CDD:197544 59/98 (60%)
SPEC 1515..1726 CDD:238103 127/210 (60%)
SPEC 1729..1939 CDD:238103 109/209 (52%)
SPEC 1837..2044 CDD:238103 121/206 (59%)
SPEC 1943..2162 CDD:238103 163/218 (75%)
SPEC 2057..2271 CDD:238103 160/223 (72%)
FRQ1 2269..2426 CDD:227455 111/156 (71%)
EFh 2286..2354 CDD:238008 55/67 (82%)
EFhand_Ca_insen 2361..2431 CDD:285885 37/69 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 178 1.000 Domainoid score I2130
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2353
Inparanoid 1 1.050 2624 1.000 Inparanoid score I6
Isobase 1 0.950 - 0 Normalized mean entropy S2319
OMA 1 1.010 - - QHG51850
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 1 1.000 - - FOG0004911
OrthoInspector 1 1.000 - - oto18478
orthoMCL 1 0.900 - - OOG6_100348
Panther 1 1.100 - - LDO PTHR11915
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3104
SonicParanoid 1 1.000 - - X5245
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1514.960

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